Now showing items 1-10 of 21

    • Akathisia: An unusual movement disorder in Machado-Joseph disease 

      Pedroso, Jose Luiz [UNIFESP]; Braga-Neto, Pedro [UNIFESP]; Felicio, Andre C. [UNIFESP]; Barsottini, Orlando G. P. [UNIFESP]; Jardim, Laura B.; Saraiva-Pereira, Maria Luiza (Elsevier B.V., 2011-11-01)
    • Avaliação clínica e neurofisiológica do sistema nervoso periférico na doença de Machado-Joseph 

      Bezerra, Marcio Luiz Escorcio [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2014-09-30)
      Machado Joseph disease (MJD) or spinocerebellar ataxia (SCA) type 3 (SCA3) is the most common autosomal SCA worldwide. It is characterized by progressive cerebellar ataxia, pyramidal signs, progressive external ophthalmoplegia ...

    • Cerebellar Cognitive Affective Syndrome in Machado Joseph Disease: Core Clinical Features 

      Braga-Neto, Pedro [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Alessi, Helena [UNIFESP]; Dutra, Livia Almeida [UNIFESP]; Felicio, Andre Carvalho [UNIFESP]; Minett, Thais [UNIFESP]; Weisman, Patricia [UNIFESP]; Santos-Galduroz, Ruth F.; Bertolucci, Paulo Henrique F. [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP] (Springer, 2012-06-01)
      The cerebellum is no longer considered a purely motor control device, and convincing evidence has demonstrated its relationship to cognitive and emotional neural circuits. the aims of the present study were to establish ...

    • Cognitive and olfactory deficits in Machado-Joseph disease: A dopamine transporter study 

      Braga-Neto, Pedro [UNIFESP]; Felicio, Andre C.; Hoexter, Marcelo Q. [UNIFESP]; Pedroso, Jose Luiz; Dutra, Livia Almeida; Alessi, Helena; Minett, Thais [UNIFESP]; Santos-Galduroz, Ruth F.; Rocha, Antonio Jose da; Garcia, Lucas A. L.; Bertolucci, Paulo Henrique F.; Bressan, Rodrigo A. [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP] (Elsevier B.V., 2012-08-01)
      Cognitive and olfactory impairments have been demonstrated in patients with Machado-Joseph disease (MJD), and a possible relationship with dopaminergic dysfunction is implicated. However, there is still controversy regarding ...

    • Cognitive Deficits in Machado-Joseph Disease Correlate with Hypoperfusion of Visual System Areas 

      Braga-Neto, Pedro [UNIFESP]; Dutra, Livia Almeida [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Felicio, Andre C. [UNIFESP]; Alessi, Helena [UNIFESP]; Santos-Galduroz, Ruth F.; Bertolucci, Paulo Henrique F. [UNIFESP]; Castiglioni, Mario Luiz V. [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Jara de Garrido, Griselda Esther; Barsottini, Orlando Graziani Povoas [UNIFESP]; Jackowski, Andrea [UNIFESP] (Springer, 2012-12-01)
      Cognitive and olfactory impairments have previously been demonstrated in patients with spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD)-SCA3/MJD. We investigated changes in regional cerebral ...

    • Excessive fragmentary myoclonus in Machado-Joseph disease 

      Santos, Diogo Fernandes dos [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Braga-Neto, Pedro [UNIFESP]; Fontes Silva, Giselle Melo [UNIFESP]; Coin de Carvalho, Luciane Bizari [UNIFESP]; Prado, Lucila B. F. [UNIFESP]; Barsottini, Orlando Graziani P. [UNIFESP]; Prado, Gilmar Fernandes do [UNIFESP] (Elsevier B.V., 2014-03-01)
      Objective: Machado-Joseph disease (MJD) is a neurodegenerative disease which usually presents several clinical findings including cerebellar ataxia and other extracerebellar features, such as Parkinsonism, dystonia, ...

    • Is Neuropathy Involved with Restless Legs Syndrome in Machado-Joseph Disease? 

      Pedroso, Jose Luiz [UNIFESP]; Escorcio Bezerra, Marcio Luiz [UNIFESP]; Braga-Neto, Pedro [UNIFESP]; Pinheiro, Denise Spinola [UNIFESP]; Minett, Thais [UNIFESP]; Prado, Gilmar Fernandes do [UNIFESP]; Manzano, Gilberto Mastrocola [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP] (Karger, 2011-01-01)
      Objective: To evaluate a group of spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) (SCA3/MJD) patients and assess whether there is an association between neuropathy and serum ferritin levels and restless ...

    • Machado-Joseph disease in Brazil: from the first descriptions to the emergence as the most common spinocerebellar ataxia 

      Pedroso, José Luiz [UNIFESP]; Braga-neto, Pedro [UNIFESP]; Radvany, João; Barsottini, Orlando Graziani Povoas [UNIFESP] (Academia Brasileira de Neurologia - ABNEURO, 2012-08-01)
      Machado-Joseph disease is an autosomal dominant inherited disorder of Azorean ancestry firstly described in 1972. Since then, several Brazilian researchers have studied clinical and genetic issues related to the disease. ...

    • A multimodal evaluation of microstructural white matter damage in spinocerebellar ataxia type 3 

      Guimaraes, Rachel P.; D'Abreu, Anelyssa; Yasuda, Clarissa L.; Franca, Marcondes C.; Silva, Beatriz H. B.; Cappabianco, Fabio A. M. [UNIFESP]; Bergo, Felipe P. G.; Lopes-Cendes, Iscia T.; Cendes, Fernando (Wiley-Blackwell, 2013-07-01)
      Although white matter damage may play a major role in the pathogenesis of spinocerebellar ataxia 3 (SCA3), available data rely exclusively upon macrostructural analyses. in this setting we designed a study to investigate ...

    • Neurophysiological Studies and Non-Motor Symptoms Prior to Ataxia in a Patient with Machado-Joseph Disease: Trying to Understand the Natural History of Brain Degeneration 

      Pedroso, Jose Luiz [UNIFESP]; Bor-Seng-Shu, Edson; Braga-Neto, Pedro [UNIFESP]; Ribeiro, Rodrigo Souza [UNIFESP]; Escorcio Bezerra, Marcio Luiz [UNIFESP]; Prado, Lucila B. F. do [UNIFESP]; Batista, Ilza Rosa [UNIFESP]; Alessi, Helena [UNIFESP]; Teixeira, Manoel Jacobsen; Manzano, Gilberto Mastrocola [UNIFESP]; Prado, Gilmar Fernandes do [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP] (Springer, 2014-08-01)
      Spinocerebellar ataxia type 3 or Machado-Joseph disease is the most common spinocerebellar ataxia. in this neurological disease, anatomical, physiological, clinical, and functional neuroimaging demonstrate a degenerative ...