Now showing items 1-7 of 7

    • Avaliação dos métodos analíticos do cloridrato de petidina e da relação entre seus aspectos de qualidade e regulatórios 

      Carvalho, Débora Xavier de [UNIFESP] (Universidade Federal de São Paulo, 2022-02-09)
      A petidina é um analgésico opioide, que possui estrutura química semelhante à da morfina. É administrado principalmente na forma de solução injetável, sob forma de cloridrato de petidina. Esse fármaco pode gerar um metabólito ...

    • The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats 

      Reksidler, Angela B.; Lima, Marcelo M. S.; Zanata, Silvio M.; Machado, Hidevaldo B.; Cunha, Claudio da; Andreatini, Roberto; Tufik, Sergio [UNIFESP]; Vital, Maria A. B. F. (Elsevier B.V., 2007-04-10)
      The present study investigated the effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib (Bextra (TM)) in the prevention of motor and cognitive impairments observed in rats after an intranigral infusion of ...

    • Distinct Effects of Intranigral L-DOPA Infusion in the MPTP Rat Model of Parkinson's Disease 

      Reksidler, Angela B.; Lima, Marcelo M. S.; Dombrowski, Patricia A.; Barnabe, Gabriela F. [UNIFESP]; Andersen, Monica L. [UNIFESP]; Tufik, Sergio [UNIFESP]; Vital, Maria A. B. F. (Springer, 2009-01-01)
      The potential neuroprotective or neurotoxic effects of 3,4-dihydroxyphenylalanine (L-DOPA) are yet to be understood. We examined the behavioral, immunohistochemical, tyrosine hydroxylase (TH) expression and neurochemical ...

    • Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission 

      Da Cunha, Claudio; Wietzikoski, Evellyn Claudia; Ferro, Marcelo Machado; Martinez, Glaucia Regina; Barbato Frazao Vital, Maria Aparecida; Hipolide, Debora [UNIFESP]; Tufik, Sergio [UNIFESP]; Canteras, Newton Sabino (Elsevier B.V., 2008-06-03)
      Rats with unilateral lesion of the substantia nigra pars compacta (SNpc) have been used as a model of Parkinson's disease. Depending on the lesion protocol and on the drug challenge, these rats rotate in opposite directions. ...

    • Intra-nigral MPTP lesion in rats: Behavioral and autoradiography studies 

      Perry, J. C.; Hipolide, D. C.; Tufik, S.; Martins, R. D.; Da Cunha, C.; Andreatini, R.; Vital, MABF (Elsevier B.V., 2005-10-01)
      The present study investigated the motor response and possible changes in binding to D-1 and D-2 receptors after intra-nigral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) infusion on rats. the results indicated that ...

    • Melatonin attenuates tyrosine hydroxylase loss and hypolocomotion in MPTP-lesioned rats 

      Capitelli, Caroline; Sereniki, Adriana; Santos Lima, Marcelo Meira [UNIFESP]; Reksidler, Angela Braga; Tufik, Sergio [UNIFESP]; Barbato Frazao Vital, Maria Aparecida (Elsevier B.V., 2008-10-10)
      Parkinson's disease is a chronic neurological disease characterized by dopaminergic neuron degeneration in the substantia nigra pars compacta. Melatonin is a powerful antioxidant agent secreted by the pineal gland which ...

    • Repeated intranigral MPTP administration: A new protocol of prolonged locomotor impairment mimicking Parkinson's disease 

      Reksidler, Angela Braga; Lima, Marcelo Meira Santos [UNIFESP]; Dombrowski, Patricia; Andersen, Monica Levy [UNIFESP]; Zanata, Silvio Marques; Andreatini, Roberto; Tufik, Sergio [UNIFESP]; Vital, Maria Aparecida Barbato Frazao (Elsevier B.V., 2008-01-30)
      Different Parkinson's disease (PD) animal models reproduce the early phase of the disease, which deny the possible existence of a synergic effect of consecutive insults to the dopaminergic neurons. We proposed a novel ...