Browsing by Subject "JAK/STAT"
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Activation of the Janus kinase/signal transducer and activator of transcription pathway in multiple myeloma is not related to point mutations in kinase and pseudokinase domains of JAK1 (Informa Healthcare, 2014-05-01)Considering the recent impact of tyrosine kinase inhibitors in the treatment of myeloproliferative disorders carrying a recurrent JAK2 mutation not identified in multiple myeloma (MM), this study aimed to search for mutations ...
Angiotensin II-induced JNK activation is mediated by NAD(P)H oxidase in isolated rat pancreatic islets (Elsevier B.V., 2012-04-10)Angiotensin II (All), the active component of the renin angiotensin system (RAS), plays a vital role in the regulation of physiological processes of the cardiovascular system, but also has autocrine and paracrine actions ...
Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients (Elsevier Ireland Ltd, 2017)JAK proteins have been linked with survival and proliferation of multiple myeloma (MM) cells
(Universidade Federal de São Paulo, 2020)A artrite reumatoide é uma doença autoimune, inflamatória e crônica, que acomete ao menos 1% da população global e afeta os pacientes com limitações e dores excruciantes, além de outras complicações sistêmicas. A causa ...