Now showing items 1-10 of 10

    • Autophagy as a Neuroprotective Mechanism Against 3-Nitropropionic Acid-Induced Murine Astrocyte Cell Death 

      Pereira, Gustavo J. S. [UNIFESP]; Tressoldi, Nicole [UNIFESP]; Hirata, Hanako [UNIFESP]; Bincoletto, Claudia [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Springer, 2013-11-01)
      Huntington's disease (HD) is a genetic neurodegenerative disorder that is characterized by severe striatal atrophy with extensive neuronal loss and gliosis. Although the molecular mechanism is not well understood, experimental ...

    • Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders? 

      Peres, Fernanda Fiel [UNIFESP]; Lima, Alvaro C.; Hallak, Jaime E. C.; Crippa, José Alexandre de Souza [UNIFESP]; Silva, Regina Helena da [UNIFESP]; Abilio, Vanessa Costhek [UNIFESP] (Frontiers Media Sa, 2018)
      Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating conditions linked to oxidative stress and neurodegeneration. When available, the pharmacological therapies for these disorders are still ...

    • Coréia: análise clínica de 119 casos 

      Mendes, Maria Fernanda [UNIFESP]; Andrade, Luiz Augusto Franco de [UNIFESP]; Ferraz, Henrique Ballalai [UNIFESP] (Academia Brasileira de Neurologia - ABNEURO, 1996-09-01)
      Chorea is a clinical syndrome characterized by abnormal involuntary arrhythmic movements, randomly distributed in time, affecting mainly the distal parts of the limbs. There are many diseases associated with chorea but the ...

    • Glutamate-induced alterations in Ca2+ signaling are modulated by mitochondrial Ca2+ handling capacity in brain slices of R6/1 transgenic mice 

      Rosenstock, T. R. [UNIFESP]; Bertoncini, C. R. A. [UNIFESP]; Teles, A. V. [UNIFESP]; Hirata, H. [UNIFESP]; Fernandes, M. J. S. [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Wiley-Blackwell, 2010-07-01)
      Huntington's disease is a neurodegenerative disorder caused by an expansion of CAGs repeats and characterized by alterations in mitochondrial functions. Although changes in Ca2+ handling have been suggested, the mechanisms ...

    • Increase in bax expression and apoptosis are associated in Huntington's disease progression 

      Teles, A. V. F. F. [UNIFESP]; Rosenstock, T. R. [UNIFESP]; Okuno, C. S. [UNIFESP]; Lopes, G. S. [UNIFESP]; Bertoncini, C. R. A. [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Elsevier B.V., 2008-06-13)
      Huntington's disease (HD) is a hereditary dominant neurodegenerative disorder and the progression of the disease may be associated with apoptosis and altered expression of apoptotic proteins. the aim of this study was to ...

    • Lack of association between PSA-NCAM expression and migration in the rostral migratory stream of a Huntington's disease transgenic mouse model 

      Moraes, Louise; Araujo de Moraes Mello, Luiz Eugenio [UNIFESP]; Shimabukuro, Marilia Kimie [UNIFESP]; Castro Batista, Claudia Maria de [UNIFESP]; Mendez-Otero, Rosalia (Wiley-Blackwell, 2009-04-01)
      Huntington's disease is a neurodegenerative autosomal disorder characterized by selective loss of striatal and cortical neurons. the mammalian brain subventricular zone contains a population of neural precursors involved ...

    • Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid 

      Rosenstock, Tatiana Rosado [UNIFESP]; Carvalho, Ana Carolina Pereira de [UNIFESP]; Jurkiewicz, Aron [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Blackwell Publishing Ltd, 2004-03-01)
      Intracellular calcium homeostasis is important for cell survival. However, increase in mitochondrial calcium (Ca-m(2+)) induces opening of permeability transition pore (PTP), mitochondrial dysfunction and apoptosis. Since ...

    • Níveis de mindfulness e injustiça percebida em indivíduos com Doença de Huntington e familiares 

      Silva, Tânia Fernandes [UNIFESP] (Universidade Federal de São Paulo, 2017-10-31)
      Introdução: A Doença de Huntington (D.H.) é uma desordem neurodegenerativa rara, caracterizada por movimentos involuntários, disfunções psiquiátricas, emocionais e cognitivas, alterações de personalidade, depressão e ...

    • Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid 

      Rosenstock, T. R. [UNIFESP]; Abilio, V. C. [UNIFESP]; Frussa-Filho, R. [UNIFESP]; Kiyomoto, B. H. [UNIFESP]; Smaili, Soraya Soubhi [UNIFESP] (Elsevier B.V., 2009-01-01)
      Huntington's disease (HD) is a neurodegenerative disorder, with an age-related onset and a progressive development, characterized by choreiform movements. 3-Nitropropionic acid (3NP) induces the inhibition of succinate ...

    • Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy 

      Oliveira-Giacomelli, Agatha; Naaldijk, Yahaira; Sarda-Arroyo, Laura; Goncalves, Maria C. B. [UNIFESP]; Correa-Velloso, Juliana; Pillat, Micheli M.; Souza, Hellio D. N. de; Ulrich, Henning (Frontiers Media Sa, 2018)
      Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system. In neurological ...