Now showing items 1-10 of 26

    • Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp 

      Brito, Adriana S.; Arimateia, Dayse S.; Souza, Lucilla R.; Lima, Marcelo A.; Santos, Vanessa O.; Medeiros, Valquiria P. [UNIFESP]; Ferreira, Paula A.; Silva, Rodrigo A.; Ferreira, Carmen V.; Justo, Giselle Z. [UNIFESP]; Leite, Edda L.; Andrade, Giulianna P. V.; Oliveira, Fernanda W.; Nader, Helena B. [UNIFESP]; Chavante, Suely F. (Elsevier B.V., 2008-11-01)
      The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute ...

    • Avaliação da profilaxia do tromboembolismo venoso em hospital de grande porte 

      Carneiro, João Luiz De Aquino; Targueta, Gabriel Pelegrineti [UNIFESP]; Marino, Lucas Oliveira (Colégio Brasileiro de Cirurgiões, 2010-06-01)
      OBJECTIVE: This study aimed at assessing the adequacy of thromboprophylaxis in a high complexity hospital in Vitória - ES, analysing the possible predictors of inadequate prescriptions and/or procedures. METHODS: A ...

    • The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans 

      Barros, Nilana M. T. [UNIFESP]; Nascimento, Fabio D. [UNIFESP]; Oliveira, Vitor [UNIFESP]; Juliano, Maria Aparecida [UNIFESP]; Juliano, Luiz [UNIFESP]; Loisel, Thomas; Nader, Helena B. [UNIFESP]; Boileau, Guy; Tersariol, Ivarne L. S.; Carmona, Adriana K. [UNIFESP] (Elsevier B.V., 2008-01-01)
      The PHEX gene (phosphate-regulating gene with homologies to endopeptidase on the X chromosome) identified as a mutated gene in patients with X-linked hypophosphatemia (XLH), encodes a protein (PHEX) that shows striking ...

    • Dosagem da heparina em cirurgia cardíaca com circulação extracorpórea 

      Moraes Neto, Fernando Ribeiro de [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Dietrich, Carl Peter [UNIFESP]; Buffolo, Enio [UNIFESP] (Sociedade Brasileira de Cirurgia Cardiovascular, 1996-09-01)
      In order to quantify seric levels of heparin, its attenuation as a time function and its residual value after neutralization with protamine sulfate, blood samples were collected, at pre-set intervals, from 27 patients ...

    • Efeito da heparinização sistêmica em fígado e rim de suínos submetidos a choque hipovolêmico, clampeamento aórtico e reperfusão 

      Silva, Seleno Glauber De Jesus [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2019-11-28)
      Objectives: To develop a model of hemorrhagic shock (HS), aortic clamping (AC) and ischemia-reperfusion (IR) in pigs, and to study functional, morphological and immunohistochemical (IHC) effects in the liver and kidneys ...

    • Estabilidade do cloridrato de vancomicina empregado na técnica de selo com antimicrobianos para descontaminação de cateteres intravenosos centrais 

      Barros, Daniele Porto [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2019-08-29)
      Introduction: Bloodstream infection related to central lines catheter is a frequent complication in children undergoing bone marrow transplantation, and the use of an antimicrobial lock technique, such as vancomycin ...

    • F-19 labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy 

      Lima, Marcelo A. [UNIFESP]; Cavalheiro, Renan P. [UNIFESP]; Viana, Gustavo M. [UNIFESP]; Meneghetti, Maria C. Z. [UNIFESP]; Rudd, Timothy R.; Skidmore, Mark A.; Powell, Andrew K.; Yates, Edwin A. [UNIFESP] (Springer, 2017)
      Studying polysaccharide-protein interactions under physiological conditions by conventional techniques is challenging. Ideally, macromolecules could be followed by both in vitro spectroscopy experiments as well as in tissues ...

    • Fret Studies of Conformational Changes in Heparin-Binding Peptides 

      Souza, Eduardo Sergio de; Katagiri, Alberto H.; Juliano, Luiz [UNIFESP]; Juliano, Maria Aparecida [UNIFESP]; Pimenta, Daniel Carvalho; Ito, Amando Siuiti (Springer, 2014-05-01)
      FRET (Forster Resonance Energy Transfer) was applied to study structural properties of heparin-binding peptides containing the sequence XBBBXXBX where 'X' represents hydropathic or uncharged and 'B' represents basic amino ...

    • Heparin modulates the expression of genes encoding pro and anti-apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats 

      Taha, Murched Omar [UNIFESP]; Miranda-Ferreira, Regiane [UNIFESP]; Taha, Nabiha Saadi Abrahão [UNIFESP]; Monteiro, Hugo Pequeno [UNIFESP]; Caricati-Neto, Afonso [UNIFESP]; Fagundes, Djalma José [UNIFESP] (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2014-07-01)
      PURPOSE: To investigate if expression of genes encoding pro and anti-apoptotic proteins in the rat enteric endothelial cells stimulated by intestinal ischemia followed by reperfusion (IR) can be modified by treatment with ...

    • Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells 

      Ghezzi, Silvia; Cooper, Lynsay; Rubio, Alicia; Pagani, Isabel; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Pelletier, Julien; Meneghetti, Maria Cecilia Z. [UNIFESP]; Lima, Marcelo A. [UNIFESP]; Skidmore, Mark A.; Broccoli, Vania; Yates, Edwin A. [UNIFESP]; Vicenzi, Elisa (Elsevier Science Bv, 2017)
      The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of ...