Browsing by Subject "Gene therapy"

Now showing items 1-10 of 12

    • Endostatin gene therapy enhances the efficacy of IL-2 in suppressing metastatic renal cell carcinoma in mice 

      Goes Rocha, Flavia Gomes de [UNIFESP]; Barbosa Chaves, Karen Cristina [UNIFESP]; Chammas, Roger; Schatzmann Peron, Jean Pierre; Rizzo, Luiz Vicente; Schor, Nestor [UNIFESP]; Bellini, Maria Helena [UNIFESP] (Springer, 2010-09-01)
      We investigated whether the administration of IL-2 combined with endostatin gene therapy was able to produce additive or even synergistic immunomodulatory activity in a mouse model of metastatic renal carcinoma. Renca cells ...

    • Endostatin neoadjuvant gene therapy extends survival in an orthotopic metastatic mouse model of renal cell carcinoma 

      Braga, Marina de Souza [UNIFESP]; Chaves, Karen Barbosa [UNIFESP]; Chammas, Roger [UNIFESP]; Schor, Nestor [UNIFESP]; Bellini, Maria Helena [UNIFESP] (Elsevier B.V., 2012-06-01)
      Despite recent advances in targeted therapy, renal cell carcinoma (RCC) remains one of the most lethal urologic malignancies. Approximately 30% of patients with localised RCC will develop metastases after curative surgery. ...

    • Gene transfer to primary corneal epithelial cells with an integrating lentiviral vector 

      Oliveira, Lauro Augusto De [UNIFESP]; Kim, Charles; Sousa, Luciene Barbosa De [UNIFESP]; Schwab, Ivan R.; Rosenblatt, Mark I. (Conselho Brasileiro de Oftalmologia, 2010-10-01)
      PURPOSE: To evaluate the transfer of heterologous genes carrying a Green Fluorescent Protein (GFP) reporter cassette to primary corneal epithelial cells ex vivo. METHODS: Freshly enucleated rabbit corneoscleral tissue was ...

    • Granulocyte-macrophage colony-stimulating factor gene based therapy for acute limb ischemia in a mouse model 

      Sacramento, Chester Bittencourt [UNIFESP]; Cantagalli, Vanessa Dionisio [UNIFESP]; Grings, Mariana [UNIFESP]; Carvalho, Leonardo Pinto [UNIFESP]; Costa Baptista-Silva, Jose Carlos [UNIFESP]; Beutel, Abram [UNIFESP]; Bergamaschi, Cassia Toledo [UNIFESP]; Campos, Ruy Ribeiro [UNIFESP]; Moraes, Jane Zveiter de [UNIFESP]; Takiya, Christina Maeda; Samoto, Vivian Yochiko; Borojevic, Radovan; Silva, Flavia Helena da [UNIFESP]; Nardi, Nance Beyer; Dohmann, Hans Fernando; Silva Junior, Hamilton; Valero, Valderez Bastos [UNIFESP]; Han, Sang Won [UNIFESP] (Wiley-Blackwell, 2009-04-01)
      Background Granulocyte-colony-stimulating factor (GM-CSF) is a pleiotropic factor for hematopoiesis that stimulates myeloblasts, monoblasts and mobilization of bone marrow stem cells. Therefore, the GM-CSF gene is a potential ...

    • High Doses of Vegf165 as Sole Gene Therapy for Patients with Inoperable Coronary Artery Disease and Refractory Angina: 1-Year Follow-Up From a Phase I/ii Clinical Trial 

      Rodrigues, Clarissa B.; Sant'Anna, Roberto T.; Eibel, Bruna; Salles, Felipe A.; Nardi, Nance B.; Han, Sang Won [UNIFESP]; Ludwig, Eduardo; Grossman, Gabriel; Marques, Mauricio B.; Markoski, Melissa M.; Sant'Anna, Joao Ricardo M.; Prates, Paulo R.; Nesralla, Ivo A.; Kalil, Renato (Lippincott Williams & Wilkins, 2011-11-22)

    • Injectable alginate hydrogel for enhanced spatiotemporal control of lentivector delivery in murine skeletal muscle 

      Stilhano, Roberta S. [UNIFESP]; Madrigal, Justin L.; Wong, Kevin; Williams, Priscilla A.; Martin, Priscila K. M. [UNIFESP]; Yamaguchi, Fabio S. M.; Samoto, Vivian Y. [UNIFESP]; Han, Sang W. [UNIFESP]; Silva, Eduardo A. (Elsevier Science Bv, 2016)
      Hydrogels are an especially appealing class of biomaterials for gene delivery vehicles as they can be introduced into the body with minimally invasive procedures and are often applied in tissue engineering and regenerative ...

    • Nanopartículas de sílica mesoporosa quimicamente modificadas para transfecção com DNA plasmidial 

      Crapina, Laura Cipriano [UNIFESP] (Universidade Federal de São Paulo, 2019-04-10)
      A terapia gênica regula a expressão de um gene terapêutico pela transferência de ácidos nucleicos para o interior das células alvo. No entanto, os ácidos nucleicos por si só apresentam dificuldades ...

    • Produtos de terapias avançadas e sua regulamentação no Brasil 

      Silva, Monique Lopes da [UNIFESP] (Universidade Federal de São Paulo, 2021-08-20)
      Introdução: A medicina humana está em constante evolução, desenvolvendo e incorporando diversos avanços tecnólogicos. Mediante a este cenário, as terapias avançadas vêm sendo aprimoradas e têm desafiado as agências ...

    • Terapia gênica com VEGF para angiogênese na angina refratária: ensaio clínico fase I/II 

      Kalil, Renato A. K.; Salles, Felipe Borsu De; Giusti, Imarilde Inês; Rodrigues, Clarissa Garcia; Han, Sang Won [UNIFESP]; Sant'anna, Roberto Tofani; Ludwig, Eduardo; Grossman, Gabriel; Prates, Paulo Roberto Lunardi; Sant'anna, João Ricardo Michelin; Teixeira Filho, Guaracy Fernandes; Nardi, Nance Beyer; Nesralla, Ivo Abrahão (Sociedade Brasileira de Cirurgia Cardiovascular, 2010-09-01)
      OBJECTIVE: Safety, feasibility and early myocardial angiogenic effects evaluation of transthoracic intramyocardial phVEGF165 administration for refractory angina in no option patients. METHODS: Cohort study, in which 13 ...

    • Terapia gênica de isquemia de membro de camundongo com os genes Gm-Csf e M-Csf 

      Mansano, Barbara Sampaio Dias Martins [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2017)
      Cancer is the world's largest public health problem and the second leading cause of death in the United States. It is a disease associated with aging. Infections are a serious cause of morbidity and mortality in cancer ...