Browsing by Subject "Epididymis"
Now showing items 1-10 of 13
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Androgen deprivation from pre-puberty to peripuberty interferes in proteins expression in pubertal and adult rat epididymis
(Elsevier B.V., 2013-07-01)Few studies have focused on experimental testosterone deprivation in immature animals. Therefore, this study used sexually immature rats aiming to evaluate the testes and epididymis histology and proteins expression in ...
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Dynamic changes in the spatio-temporal expression of the beta-defensin SPAG11C in the developing rat epididymis and its regulation by androgens
(Elsevier B.V., 2015-03-15)Herein, we characterized the spatio-temporal expression, cellular distribution and regulation by androgens of the P-defensin SPAG11C, the rat ortholog of the human SPAG11B isoform C, in the developing epididymis by using ...
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Effects of the oestrogen receptor antagonist Fulvestrant on expression of genes that affect organization of the epididymal epithelium
(Wiley-Blackwell, 2014-07-01)The role of oestrogens in epididymal function is still unclear. Knockout of the oestrogen receptor ESR1 (Esr1-/-) or treatment with the anti-oestrogen Fulvestrant affect epididymal milieu and sperm motility. We investigated ...
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Exposição prolongada aos quimioterápicos 5-fluorouracil e metotrexato em concentrações ambientalmente relevantes: Avaliação da toxicidade testicular e danos ao DNA de ratos
(Universidade Federal de São Paulo, 2022-01-24)Drogas antineoplásicas, utilizadas para tratamento de pacientes com câncer, atuam na prevenção do crescimento do tumor por meio do controle das divisões celulares. Um dos mecanismos de ação ocorre por interação com o DNA ...
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Expressão Espaço-Temporal Do Receptor De Glicocorticoide No Desenvolvimento Epididimário
(Universidade Federal de São Paulo (UNIFESP), 2017-07-31)O epidídimo é um órgão do trato reprodutor masculino responsável pela maturação, transporte, estocagem e proteção dos espermatozoides e, assim fundamental para fertilidade masculina. O desenvolvimento embrionário e pós-natal ...
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Expression and localization of muscarinic acetylcholine receptor subtypes in rat efferent ductules and epididymis
(Springer, 2006-01-01)The expression of muscarinic acetylcholine receptor (mAChR) subtypes (M-1-M-5) was studied in the rat efferent ductules and epididymis at the mRNA and protein levels. the relative abundance of each mAChR transcript subtype ...
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Glucocorticoid receptor in the rat epididymis: Expression, cellular distribution and regulation by steroid hormones
(Elsevier B.V., 2010-08-30)Glucocorticoids regulate several physiological functions, including reproduction, in mammals. Curiously, little is known about glucocorticoid-induced effects on the epididymis, an androgen-dependent tissue with vital role ...
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Impact of adrenalectomy and dexamethasone treatment on testicular morphology and sperm parameters in rats: insights into the adrenal control of male reproduction
(Wiley-Blackwell, 2014-11-01)Here we investigated the hypothesis that normal levels of glucocorticoids, a class of adrenal steroid hormones, are required for normal testicular and epididymal functions. We examined the effects of the manipulation of ...
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Localização, função e regulação de receptores muscarínicos em dúctulos eferentes e epidídimo de ratos
(Universidade Federal de São Paulo (UNIFESP), 2006-02-22)The presence of muscarinic acetylcholine receptors has been shown in the epididymis from 50 day-old rats by molecular, functional and radioligand binding assays performed in our laboratory. Considering that a variety of ...
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Muscarinic Acetylcholine Receptor Subtypes in the Male Reproductive Tract
(Humana Press Inc, 2010-01-01)In mammals, at least five different muscarinic acetylcholine receptor subtypes (mAChRs; M(1)-M(5)) are known to be widely expressed and distributed in different tissues from different species. They mediate distinct ...
