Browsing by Subject "Endothelial cells"
Now showing items 1-10 of 11
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Acquisition of anoikis resistance promotes alterations in the Ras/ERK and PI3K/Akt signaling pathways and matrix remodeling in endothelial cells
(Springer, 2017)Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix. Anoikis resistance is a critical mechanism in tumor metastasis. Cancer cells deregulate and adapt their metabolism to survive in ...
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Aging Exacerbates Microvascular Endothelial Damage Induced by Circulating Factors Present in the Serum of Septic Patients
(Oxford Univ Press Inc, 2013-06-01)The elderly patients show a significantly elevated mortality rate during sepsis than younger patients, due to their higher propensity to microvascular dysfunction and consequential multiorgan failure. We tested whether ...
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Bauhinia bauhinioides cruzipain inhibitor reduces endothelial proliferation and induces an increase of the intracellular Ca2+ concentration
(Servicio Publicaciones Universidad Navarra, 2010-12-01)Proteinase inhibitors, isolated from different types of Bauhinia, have an effect on apoptosis, angiogenesis and inflammation. the Bauhinia bauhinioides cruzipain inhibitor (BbCI) is a Kunitz-type inhibitor and inactivates ...
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Brown spider (Loxosceles intermedia) venom triggers endothelial cells death by anoikis
(Elsevier B.V., 2012-09-01)Brown spider (Loxosceles sp.) venom affects the endothelium of vessels and triggers disruptive activity in the subendothelial matrix. the vascular disorders observed after venom exposure include leukocyte and platelet ...
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Brown spider venom toxins interact with cell surface and are endocytosed by rabbit endothelial cells
(Elsevier B.V., 2010-09-15)Bites from the Loxosceles genus (brown spiders) cause severe clinical symptoms, Including dermonecrotic injury, hemorrhage, hemolysis, platelet aggregation and renal failure. Histological findings of dermonecrotic lesions ...
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Efeito da resistência à morte celular por perda de adesão (anoikis) na expressão do sindecam-4 e no ciclo celular de células endoteliais em cultura
(Universidade Federal de São Paulo, 2013-04-25)Tumors produce several molecules that facilitate their proliferation, invasion and maintenance, especially proteoglycans. The syndecan-4, a heparan sulfate proteoglycan, can act as a co-receptor of growth factors and ...
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Effect of bauhinia bauhinioides kallikrein inhibitor on endothelial proliferation and intracellular calcium concentration
(Verduci Publisher, 2014-01-01)OBJECTIVES: Proteinase inhibitors act as a defensive system against predators e.g. insects, in plants. Bauhinia bauhinioides kallikrein inhibitor (BbKI) is a serine proteinase inhibitor, isolated from seeds of Bauhinia ...
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Endothelium-derived nitric oxide (NO) activates the NO-epidermal growth factor receptor-mediated signaling pathway in bradykinin-stimulated angiogenesis
(Elsevier B.V., 2014-09-15)Nitric oxide (NO) is involved in angiogenesis and stimulates the EGF-R signaling pathway. Stimulation of different endothelial cell lines with bradykinin (BK) activates the endothelial NO synthase (eNOS) and promotes EGF-R ...
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Estudos in vitro da participação da leptina em células endoteliais pulmonares de ratos nutridos e desnutridos intrauterinamente
(Universidade Federal de São Paulo, 2014-03-02)Studies suggest that intrauterine malnutrition can "program" the fetal tissues making them more prone to disorders associated with food, such as type 2 diabetes, metabolic syndrome and other chronic diseases in adulthood ...
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Glycosaminoglycan backbone is not required for the modulation of hemostasis: Effect of different heparin derivatives and non-glycosaminoglycan analogs
(Elsevier B.V., 2012-06-01)Heparin and its derivatives are known to regulate a variety of pathophysiological events related to vascular biology. in the present manuscript we examine a variety of heparinomimetics biochemically (electrophoretic behavior ...
