Browsing by Subject "Dopamine"
Now showing items 1-10 of 49
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Acute systemic blockade of D2 receptors does not accelerate the extinction of cocaine-associated place preference
(Elsevier B.V., 2009-12-04)Facilitation of extinction can be used as a therapeutic tool in treatment of both post-traumatic stress disorder and drug addiction. the present study examined whether the blockade of D2 receptors before each extinction ...
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Age-related effects on genital reflexes induced by paradoxical sleep deprivation and cocaine in rats
(Elsevier B.V., 2004-02-01)Although sexual function often decreases with age, a recent study demonstrated that paradoxical sleep deprivation (PSD) was effective in inducing penile erection (PE) in 60% of 22-month-old PSD rats after acute cocaine ...
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Alcohol consumption increases locomotion in an open field and induces Fos-immunoreactivity in reward and approach/withdrawal-related neurocircuitries
(Elsevier Science Inc, 2016)Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and take the drug, loss of control in limiting intake and, eventually, the emergence of a negative emotional state when access to the ...
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Análise imunoistoquímica do processo oponente da regulação afetiva em resposta ao uso crônico de álcool
(Universidade Federal de São Paulo (UNIFESP), 2018-10-25)Objective: The neurotransmitters dopamine and CRF have been associated, respectively, to the neural pathways responsible for the positive and negative reinforcing effect of alcohol. This study had the following objectives: ...
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Anhydroecgonine methyl ester, a cocaine pyrolysis product, may contribute to cocaine behavioral sensitization
(Elsevier Ireland Ltd, 2017)Crack cocaine has a high potential to induce cocaine addiction and its smoke contains cocaine's pyrolysis product anhydroecgonine methyl ester (AEME), a partial agonist at M-1- and M-3-muscarinic acetylcholine receptor and ...
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Atenção visual em crianças com migrânea: um estudo comparativo controlado
(Universidade Federal de São Paulo (UNIFESP), 2011-06-29)Objective: To evaluate the visual attention of children with migraine and compare to the headache free control group. Method: 30 children with migraine, with (n=5) and without aura (n=25), which fulfill the gInternational ...
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Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys
(Springer, 2009-08-01)Diphenhydramine (DPH) is an over-the-counter medication used in the treatment of allergic symptoms. While DPH abuse is infrequent, recent preclinical evidence suggests that DPH and cocaine combinations may have enhanced ...
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Caracterização comportamental, bioquímica e farmacológica do modelo de estresse crônico por restrição de movimento
(Universidade Federal de São Paulo (UNIFESP), 2019-08-23)Stress can be defined as any stimulus that represents a real or virtual threat to homeostasis. When stress becomes chronic, there is an allostatic overload with pathological consequences. The main goal of this study was ...
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Cellular prion protein (PrPC) modulates ethanol-induced behavioral adaptive changes in mice
(Elsevier B.V., 2014-09-01)Chronic consumption of drugs with addictive potential induces profound synaptic changes in the dopaminergic mesocorticolimbic pathway that underlie the long-term behavioral alterations seen in addicted subjects. Thus, ...
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Chronic stress during paradoxical sleep deprivation increases paradoxical sleep rebound: Association with prolactin plasma levels and brain serotonin content
(Elsevier B.V., 2008-10-01)Previous studies suggest that stress associated to steep deprivation methods can affect the expression of steep rebound. in order to examine this association and possible mechanisms, rats were exposed to footshock stress ...
