Now showing items 1-9 of 9

    • Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance 

      Lopes, Debora de Oliveira; Fonseca Schamber-Reis, Bruno Luiz; Regis-da-Silva, Carlos Gustavo; Rajao, Matheus Andrade; DaRocha, Wanderson Duarte; Macedo, Andrea Mara; Franco, Gloria Regina; Nardelli, Sheila Cristina [UNIFESP]; Schenkman, Sergio [UNIFESP]; Hoffmann, Jean-Sebastein; Cazaux, Christophe; Junho Pena, Sergio Danilo; Ribeiro Teixeira, Santuza Maria; Machado, Carlos Renato (Elsevier B.V., 2008-11-01)
      Mammalian DNA polymerase p is a nuclear enzyme involved in the base excision and single-stranded DNA break repair pathways. in trypanosomatids, this protein does not have a defined cellular localization, and its function ...

    • Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions 

      Moraes, Maria Carolina S.; Andrade, Annabel Quinet de; Carvalho, Helotonio [UNIFESP]; Guecheva, Temenouga; Agnoletto, Mateus H.; Henriques, Joao A. P.; Sarasin, Alain; Stary, Anne; Saffi, Jenifer; Menck, Carlos F. M. (Elsevier B.V., 2012-01-01)
      Doxorubicin (DOX) is an important tumor chemotherapeutic agent, acting mainly by genotoxic action. This work focus on cell processes that help cell survival, after DOX-induced DNA damage. in fact, cells deficient for XPA ...

    • Chromatin and nuclear organization in Trypanosoma cruzi 

      Elias, Maria Carolina; Nardelli, Sheila Cristina [UNIFESP]; Schenkman, Sergio [UNIFESP] (Future Medicine Ltd, 2009-10-01)
      A total of 100 years have passed since the discovery of the protozoan Trypanosoma cruzi, the etiologic agent of Chagas' disease. Since its discovery, the molecular and cellular biology of this early divergent eukaryote, ...

    • Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma 

      Santos, Juliana Carvalho; Bastos, Andre Uchimura [UNIFESP]; Cerutti, Janete Maria [UNIFESP]; Ribeiro, Marcelo Lima (Biomed Central Ltd, 2013-02-15)
      Background: Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. ...

    • DNA damage induced by the anthracycline cosmomycin D in DNA repair-deficient cells 

      Carvalho, Helotonio [UNIFESP]; Garrido, Leandro M.; Furlan, Renata L. A.; Padilla, Gabriel; Agnoletto, Mateus; Guecheva, Temenouga; Henriques, Joao A. P.; Saffi, Jenifer; Martins Menck, Carlos Frederico (Springer, 2010-04-01)
      Anthracyclines have been widely used as antitumor agents, playing a crucial role in the successful treatment of many types of cancer, despite some side effects related to cardiotoxicity. New anthracyclines have been designed ...

    • DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions 

      Schamber-Reis, Bruno Luiz Fonseca; Nardelli, Sheila Cristina [UNIFESP]; Regis-Silva, Carlos Gustavo; Campos, Priscila Carneiro; Cerqueira, Paula Gonçalves; Lima, Sabrina Almeida; Franco, Gloria Regina; Macedo, Andréa Mara; Pena, Sergio Danilo Junho; Cazaux, Christophe; Hoffmann, Jean-Sebastien; Motta, Maria Cristina Machado; Schenkman, Sergio [UNIFESP]; Teixeira, Santuza Maria Ribeiro; Machado, Carlos Renato (Elsevier B.V., 2012-06-01)
      Specific DNA repair pathways from Trypanosoma cruzi are believed to protect genomic DNA and kinetoplast DNA (kDNA) from mutations. Particular pathways are supposed to operate in order to repair nucleotides oxidized by ...

    • Modificações em marcas epigenéticas em histonas ao longo da gênese do melanoma 

      Meliso, Fabiana Marcelino [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2011)
      Entre os principais transtornos mundiais, o cancer permanece como a segunda doenca responsavel pelo maior numero de mortes no mundo e o melanoma e, cada vez mais, um dos tipos mais preocupantes de tumor. Os tumores, como ...

    • Subtelomeric I-Scel-Mediated Double-Strand Breaks Are Repaired by Homologous Recombination in Trypanosoma cruzi 

      Chiurillo, Miguel A.; Moraes Barros, Roberto R.; Souza, Renata Torres [UNIFESP]; Marini, Marjorie Mendes [UNIFESP]; Antonio, Cristiane Regina [UNIFESP]; Cortez, Danielle Rodrigues [UNIFESP]; Curto, Maria A.; Lorenz, Hernan A.; Schijman, Alejandro G.; Ramirez, Jose L.; Silveira, Jose Franco da [UNIFESP] (Frontiers Media Sa, 2016)
      Trypanosoma cruzi chromosome ends are enriched in surface protein genes and pseudogenes (e.g., trans-sialidases) surrounded by repetitive sequences. It has been proposed that the extensive sequence variability among members ...

    • Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis 

      Carvalho, Helotonio [UNIFESP]; Ortolan, Tatiana G.; dePaula, Tomas; Leite, Ricardo A.; Weinlich, Ricardo; Amarante-Mendes, Gustavo P.; Martins Menck, Carlos Frederico (Elsevier B.V., 2008-06-01)
      p53 activation is one of the main signals after DNA damage, controlling cell cycle arrest, DNA repair and apoptosis. We have previously shown that confluent nucleotide excision repair (NER)-deficient cells are more resistant ...