Browsing by Subject "DNA methylation"

Now showing items 1-10 of 19

    • Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma 

      Sonaglio, Viviane; Carvalho, Ana Carolina de [UNIFESP]; Toledo, Silvia Regina Caminada de [UNIFESP]; Souza, Carolina Salinas de [UNIFESP]; Carvalho, Andre L.; Petrilli, Antonio Sergio [UNIFESP]; Camargo, Beatriz de; Vettore, Andre L. [UNIFESP] (Dove Medical Press Ltd, 2013-01-01)
      Osteosarcoma (OS) is the eighth most common form of childhood and adolescence cancer. Approximately 10%-20% of patients present metastatic disease at diagnosis and the 5-year overall survival remains around 70% for ...

    • Abnormal Epigenetic Regulation of Immune System during Aging 

      Jasiulionis, Miriam G. [UNIFESP] (Frontiers Media Sa, 2018)
      Epigenetics refers to the study of mechanisms controlling the chromatin structure, which has fundamental role in the regulation of gene expression and genome stability. Epigenetic marks, such as DNA methylation and histone ...

    • Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma 

      Santos, Juliana Carvalho; Bastos, Andre Uchimura [UNIFESP]; Cerutti, Janete Maria [UNIFESP]; Ribeiro, Marcelo Lima (Biomed Central Ltd, 2013-02-15)
      Background: Gene silencing of the repair genes MLH1 and MGMT was shown to be a mechanism underlying the development of microsatellite instability (MSI), a phenotype frequently associated with various human malignancies. ...

    • DNA and histone methylation in gastric carcinogenesis 

      Calcagno, Danielle Queiroz [UNIFESP]; Gigek, Carolina Oliveira [UNIFESP]; Chen, Elizabeth Suchi [UNIFESP]; Burbano, Rommel Rodriguez; Cardoso Smith, Marilia de Arruda [UNIFESP] (Baishideng Publishing Group Inc, 2013-02-28)
      Epigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin ...

    • DNA methylation landscape of hepatoblastomas reveals arrest at early stages of liver differentiation and cancer-related alterations 

      Maschietto, Mariana; Rodrigues, Tatiane Cristina; Kashiwabara, Andre Yoshiaki; Souza de Araujo, Erica Sara; Marques Aguiar, Talita Ferreira; Lima da Costa, Cecilia Maria; da Cunha, Isabela Werneck; Vasques, Luciana dos Reis; Cypriano, Monica [UNIFESP]; Brentani, Helena; Caminada de Toledo, Silvia Regina [UNIFESP]; Pearson, Peter Lees; Carraro, Dirce Maria; Rosenberg, Carla; Krepischi, Ana C. V. (Impact Journals Llc, 2017)
      Hepatoblastomas are uncommon embryonal liver tumors accounting for approximately 80% of childhood hepatic cancer. We hypothesized that epigenetic changes, including DNA methylation, could be relevant to hepatoblastoma ...

    • DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer 

      Silva, T. D. [UNIFESP]; Felipe, A. V. [UNIFESP]; Vidigal, V. M. [UNIFESP]; Saad, S. S. [UNIFESP]; Forones, N. M. [UNIFESP] (Funpec-Editora, 2017)
      Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many ...

    • DNA methylation, ageing and ribosomal genes activity 

      Carvalho, Cristina Valletta de [UNIFESP]; Payão, Spencer Luiz Marques [UNIFESP]; Smith, Marilia de Arruda Cardoso [UNIFESP] (Kluwer Academic Publ, 2000-01-01)
      DNA methylation is an epigenetic mechanism controlling of gene expression. We studied the effect of a demethylation agent 5-azacytidine, on ribosomal gene activity observed by Nucleolus Staining Giemsa in the chromosomes ...

    • Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR) 

      Santoro, Marcos Leite [UNIFESP]; Ota, Vanessa Kiyomi [UNIFESP]; Stilhano, Roberta Sessa [UNIFESP]; Silva, Patricia Natalia [UNIFESP]; Santos, Camila Mauricio [UNIFESP]; Diana, Mariana Cepollaro [UNIFESP]; Gadelha, Ary [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Melaragno, Maria Isabel [UNIFESP]; Han, Sang Won [UNIFESP]; Abilio, Vanessa Costhek [UNIFESP]; Belangero, Sintia Iole [UNIFESP] (Elsevier B.V., 2014-08-01)
      Antipsychotic drugs (APDs) are the standard treatment for schizophrenia. the therapeutic effect of these drugs is dependent upon the dopaminergic D2 blockade, but they also modulate other neurotransmitter pathways. the ...

    • Epigenetic mechanisms in gastric cancer 

      Gigek, Carolina Oliveira [UNIFESP]; Chen, Elizabeth Suchi [UNIFESP]; Calcagno, Danielle Queiroz [UNIFESP]; Wisnieski, Fernanda [UNIFESP]; Burbano, Rommel Rodriguez; Cardoso Smith, Marilia Arruda [UNIFESP] (Future Medicine Ltd, 2012-06-01)
      Cancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number ...

    • Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: Relevance to neuropsychiatric disorders 

      Santoro, Marcos Leite [UNIFESP]; Santos, Camila Mauricio [UNIFESP]; Ota, Vanessa Kiyomi [UNIFESP]; Gadelha, Ary [UNIFESP]; Stilhano, Roberta Sessa [UNIFESP]; Diana, Mariana Cepollaro [UNIFESP]; Silva, Patricia Natalia [UNIFESP]; Nery Spindola, Leticia Maria [UNIFESP]; Melaragno, Maria Isabel [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Han, Sang Won [UNIFESP]; Abilio, Vanessa Costhek [UNIFESP]; Belangero, Sintia Iole [UNIFESP] (Elsevier B.V., 2014-11-30)
      The spontaneously hypertensive rat (SHR) strain was shown to be a useful animal model to study several behavioral, pathophysiological and pharmacological aspects of schizophrenia and attention-deficit/hyperactivity disorder. ...