Browsing by Subject "DNA damage"

Now showing items 1-10 of 45

    • Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats 

      Leite, Aline de Lima; Santiago, Joel Ferreira; Levy, Flavia Mauad; Maria, Andrea Gutierrez; Fernandes, Mileni da Silva; Salvadori, Daisy Maria Favero; Ribeiro, Daniel Araki [UNIFESP]; Rabelo Buzalaf, Marflia Afonso (Sage Publications Ltd, 2007-05-01)
      Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been some speculation that excess fluoride could cause an impact on genome integrity. in the current study, the potential DNA ...

    • Acute crack cocaine exposure induces genetic damage in multiple organs of rats 

      Moretti, Eduardo Gregolin [UNIFESP]; Yujra, Veronica Quispe [UNIFESP]; Claudio, Samuel Rangel [UNIFESP]; Silva, Marcelo Jose Dias; Vilegas, Wagner; Pereira, Camilo Dias Seabra [UNIFESP]; De Oliveira, Flavia [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP] (Springer Heidelberg, 2016)
      Crack cocaine is a very toxic product derived from cocaine. The aim of this study was to evaluate genetic damage in multiple organs of rats following acute exposure to crack cocaine. A total of 20 Wistar rats were distributed ...

    • Adolescent varicocele: improved sperm function after varicocelectomy 

      Lacerda, Jose Iran [UNIFESP]; Del Giudice, Paula Toni [UNIFESP]; Silva, Barbara Ferreira da [UNIFESP]; Nichi, Marcilio; Fariello, Roberta Maria [UNIFESP]; Fraietta, Renato [UNIFESP]; Restelli, Adriana Ester [UNIFESP]; Blumer, Camile Garcia [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP] (Elsevier B.V., 2011-03-01)
      Objective: To assess the effect of varicocelectomy on sperm function (DNA integrity and mitochondrial activity) and levels of lipid peroxidation in seminal plasma of adolescents.Design: Prospective study.Setting: Patients ...

    • Analysis of the functional aspects and seminal plasma proteomic profile of sperm from smokers 

      Antoniassi, Mariana Pereira [UNIFESP]; Intasqui, Paula [UNIFESP]; Camargo, Mariana [UNIFESP]; Zylbersztejn, Daniel Suslik [UNIFESP]; Carvalho, Valdemir Melechco; Cardozo, Karina H. M.; Bertolla, Ricardo Pimenta [UNIFESP] (Wiley, 2016)
      Objective To evaluate the effect of smoking on sperm functional quality and seminal plasma proteomic profile. Patients and Methods Sperm functional tests were performed in 20 non-smoking men with normal semen quality, ...

    • Análise morfoquantitativa, da expressão de fatores miogênicos e de mediadores inflamatórios do músculo estriado esquelético distante da lesão térmica por escaldadura em ratos wistar jovens 

      Quintana, Hananiah Tardivo [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2014-02-26)
      Burn injury (BI) is an important epidemiological problem worldwide; those occurring in children have a higher frequency and occurring by outpouring hot liquids, for scalds are among the most common accidents. BI greater ...

    • Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test 

      Scolastici, Clarissa; Lima, Rodrigo Otavio Alves de; Barbisan, Luis Fernando; Ferreira, Ana Lucia dos Anjos; Ribeiro, Daniel Araki [UNIFESP]; Salvadori, Daisy Maria Favero (Elsevier B.V., 2008-03-01)
      Epidemiological studies have provided evidence that high consumption of tomatoes effectively reduces the risk of reactive oxygen species (ROS)-mediated diseases such as cancer. Tomatoes are rich sources of lycopene, a ...

    • Aplicação do teste do micronúcleo em células da mucosa bucal como biomarcador de expoisção a mutagenos 

      Malacarne, Ingra Tais [UNIFESP] (Universidade Federal de São Paulo, 2023-03-01)
      O teste do micronúcleo vem ganhando cada vez mais espaço no biomonitoramento de populações, uma vez que se mostrou um marcador útil para a investigação de possíveis agressões genômicas sob condições ambientais adversas, ...

    • Are endogenous sex hormones related to DNA damage in paradoxically sleep-deprived female rats? 

      Andersen, Monica Levy [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Alvarenga, Tathiana Aparecida [UNIFESP]; Silva, Andressa [UNIFESP]; Araujo, Paula [UNIFESP]; Zager, Adriano [UNIFESP]; Tenório, Neuli Maria [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2010-02-01)
      The aim of this investigation was to evaluate overall DNA damage induced by experimental paradoxical sleep deprivation (PSD) in estrous-cycling and ovariectomized female rats to examine possible hormonal involvement during ...

    • Association between obesity and alteration of sperm DNA integrity and mitochondrial activity 

      Fariello, Roberta M. [UNIFESP]; Pariz, Juliana R. [UNIFESP]; Spaine, Deborah M. [UNIFESP]; Cedenho, Agnaldo P. [UNIFESP]; Bertolla, Ricardo P. [UNIFESP]; Fraietta, Renato [UNIFESP] (Wiley-Blackwell, 2012-09-01)
      OBJECTIVETo assess the effect of obesity on semen analysis, sperm mitochondrial activity and DNA fragmentation.MATERIALS and METHODSA transversal study of 305 male patients, presenting for clinical evaluation, was carried ...

    • Association between the seminal plasma proteome and sperm functional traits 

      Intasqui, Paula [UNIFESP]; Camargo, Mariana [UNIFESP]; Antoniassi, Mariana Pereira [UNIFESP]; Cedenho, Agnaldo Pereira [UNIFESP]; Carvalho, Valdemir Melechco; Morais Cardozo, Karina Helena; Zylbersztejn, Daniel Suslik [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP] (Elsevier Science Inc, 2016)
      Objective: To analyze the seminal plasma proteome and biological functions associated with sperm functional alterations. Design: Cross-sectional study. Setting: University andrology and research laboratories. Patient(s): ...