Browsing by Subject "Comet assay"

Now showing items 1-10 of 19

    • Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats 

      Leite, Aline de Lima; Santiago, Joel Ferreira; Levy, Flavia Mauad; Maria, Andrea Gutierrez; Fernandes, Mileni da Silva; Salvadori, Daisy Maria Favero; Ribeiro, Daniel Araki [UNIFESP]; Rabelo Buzalaf, Marflia Afonso (Sage Publications Ltd, 2007-05-01)
      Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been some speculation that excess fluoride could cause an impact on genome integrity. in the current study, the potential DNA ...

    • Biomonitoramento citogenético em células da mucosa bucal e sangue periférico em pintores de automóveis 

      Silva, Victor Hugo Pereira da [UNIFESP] (Universidade Federal de São Paulo, 2012-04-10)
      Os pintores de automóveis estão ocupacionalmente expostos a uma gama de substâncias danosas provenientes não somente das tintas automotivas, mas também de solventes orgânicos, hidrocarbonetos aromáticos policíclicos, ...

    • Cytogenetic biomonitoring in mucopolyssacharosis I, II and IV patients treated with enzyme replacement therapy 

      Guilheiro, Joice Marques [UNIFESP]; Chaves, Marcelo Donizetti [UNIFESP]; Martins, Ana Maria [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; D'Almeida, Vania [UNIFESP] (Informa Healthcare, 2014-12-01)
      Background and objectives: the aim of this study was to evaluate genotoxicity and mutagenicity in peripheral blood and buccal mucosal cells in mucopolysaccharidosis (MPS) I, II or VI patients.Methods: A total of 12 patients ...

    • Cytogenetic biomonitoring of peripheral blood and oral mucosa cells from car painters 

      Silva, Victor Hugo Pereira da [UNIFESP]; Moura, Carolina Foot Gomes de [UNIFESP]; Spadari-Bratfisch, Regina Celia [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP] (Informa Healthcare, 2012-09-01)
      The aim of the present study was to comparatively evaluate genomic damage and cellular death in exfoliated oral mucosa cells and peripheral blood from car painters. A total of 24 car painters and 19 healthy controls ...

    • Dragon's blood Croton palanostigma induces genotoxic effects in mice 

      Maistro, Edson Luis; Ganthous, Giulia; Machado, Marina da Silva; Zermiani, Tailyn; Andrade, Sergio Faloni de; Pires Rosa, Paulo Cesar [UNIFESP]; Perazzo, Fabio Ferreira [UNIFESP] (Elsevier B.V., 2013-05-20)
      Ethnopharmacological relevance: Dragon's blood is a dark-red sap produced by species from the genus Croton (Euphorbiaceae), which has been used as a famous traditional medicine since ancient times in many countries, with ...

    • Effect of diterpenoid kaurenoic acid on genotoxicity and cell cycle progression in gastric cancer cell lines 

      dos Santos Cardoso, Plinio Cerqueira; Machado da Rocha, Carlos Alberto; Leal, Mariana Ferreira [UNIFESP]; Bahia, Marcelo de Oliveira; Avila Alcantara, Diego Di Felipe; dos Santos, Raquel Alves; Goncalves, Natalia dos Santos; Ambrosio, Sergio Ricardo; Cavalcanti, Bruno Coelho; Moreira-Nunes, Caroline Aquino; Pessoa, Claudia do O.; Rodriguez Burbano, Rommel Mario (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
      The goal of our study was to evaluate the effect of kaurenoic acid, obtained from copaiba oil resin, in gastric cancer (GC) and a normal mucosa of stomach (MNP01) cell lines. The compound was tested at concentrations of ...

    • Evaluation of the genotoxicity of Euterpe oleraceae Mart. (Arecaceae) fruit oil (acai), in mammalian cells in vivo 

      Marques, E. S.; Froder, J. G.; Carvalho, J. C. T.; Rosa, P. C. P.; Perazzo, F. F. [UNIFESP]; Maistro, E. L. (Pergamon-Elsevier Science Ltd, 2016)
      E. oleracea is a tropical plant from the Amazon region, with its fruit used for food, and traditionally, as an antioxidant, anti-inflammatory, hypocholesterolemic, for atherosclerotic disease, and has anticancer properties. ...

    • First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (acai) in cultured human cells 

      Marques, E. S.; Tsuboy, M. S. F.; Carvalho, J. C. T.; Rosa, P. C. P.; Perazzo, F. F. [UNIFESP]; Gaivao, I. O. M.; Maistro, E. L. (Funpec-Editora, 2017)
      Euterpe oleracea Mart., popularly known as "acai", is a tropical fruit from the Amazon region where it has considerable economic importance. Acai has been used as food and for several medicinal purposes. Despite the ...

    • Genotoxic assessment of Rubus imperialis (Rosaceae) extract in vivo and its potential chemoprevention against cyclophosphamide-induced DNA damage 

      Costa Rodrigues Alves, Ana Beatriz; Santos, Rafaella Souza dos; Calil, Susana de Santana; Niero, Rivaldo; Lopes, Jhonny da Silva; Perazzo, Fabio E. [UNIFESP]; Pires Rosa, Paulo Cesar [UNIFESP]; Andrade, Sergio Faloni; Cechinel-Filho, Valdir; Maistro, Edson Luis (Elsevier B.V., 2014-05-14)
      Ethnopharmacological relevance: Rubus imperialis Cham. Schl. (Rosaceae) is frequently used in traditional medicine as hypoglycemic, antinociceptive and antiviral remedy.Materials and methods: Swiss albino mice were distributed ...

    • Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions 

      Aquino, Ivani; Tsuboy, Marcela Stefanini Ferreira; Marcarini, Juliana Cristina; Mantovani, Mário Sérgio; Perazzo, Fábio Ferreira [UNIFESP]; Maistro, Edson Luis (Funpec-editora, 2013-01-01)
      The malaria treatment recommended by the World Health Organization involves medicines derived from artemisinin, an active compound extracted from the plant Artemisia annua, and some of its derivatives, such as artesunate. ...