Now showing items 1-10 of 65

    • Acute cocaine effects in paradoxical sleep deprived male rats 

      Andersen, Monica Levy [UNIFESP]; Perry, Juliana Cini [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2005-02-01)
      Cocaine is a psychomotor drug known to cause behavioural alterations. This study was conducted to characterize behavioural response to acute cocaine injection (7 mg/kg, ip) in paradoxical sleep deprived (PSD) male rats ...

    • Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain 

      Dalio, Fernanda Montiel [UNIFESP]; Visniauskas, Bruna [UNIFESP]; Bicocchi, Eliane S.; Perry, Juliana Cini [UNIFESP]; Freua, Rodrigo [UNIFESP]; Gesteira, Tarsis Ferreira [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Machado, Mauricio Ferreira Marcondes [UNIFESP]; Tufik, Sergio [UNIFESP]; Ferro, Emer Suavinho [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Toledo, Claudio A. B.; Chagas, Jair Ribeiro [UNIFESP]; Oliveira, Vitor [UNIFESP] (Elsevier B.V., 2012-03-23)
      Many studies indicate that thimet oligopeptidase (EC3.4.24.15; TOP) can be implicated in the metabolism of bioactive peptides, including dynorphin 1-8, alpha-neoendorphin, beta-neoendorphin and GnRH. Furthermore, the higher ...

    • Acute systemic blockade of D2 receptors does not accelerate the extinction of cocaine-associated place preference 

      Yim Júnior, Alberto [UNIFESP]; Andersen, M. L. [UNIFESP]; Soeiro, A. C. [UNIFESP]; Tufik, Sergio [UNIFESP]; Oliveira, Maria Gabriela Menezes de [UNIFESP] (Elsevier B.V., 2009-12-04)
      Facilitation of extinction can be used as a therapeutic tool in treatment of both post-traumatic stress disorder and drug addiction. the present study examined whether the blockade of D2 receptors before each extinction ...

    • Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice 

      Berro, Laís Fernanda [UNIFESP]; Santos, Renan [UNIFESP]; Hollais, André Willian [UNIFESP]; Wuo-Silva, Raphael [UNIFESP]; Fukushiro, Daniela Fukue [UNIFESP]; Mári-Kawamoto, Elisa [UNIFESP]; Costa, Jacqueline Menezes [UNIFESP]; Trombin, Thaís Fernanda [UNIFESP]; Patti, Camila de Lima [UNIFESP]; Grapiglia, Stephanie Berzin [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Frussa Filho, Roberto [UNIFESP] (Elsevier B.V., 2014-09-05)
      Sleep deprivation is common place in modern society. Nowadays, people tend to self-impose less sleep in order to achieve professional or social goals. in the social context, late-night parties are frequently associated ...

    • Age-related effects on genital reflexes induced by paradoxical sleep deprivation and cocaine in rats 

      Andersen, Monica Levy [UNIFESP]; Bignotto, Magda [UNIFESP]; Papale, Ligia Assumpção [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2004-02-01)
      Although sexual function often decreases with age, a recent study demonstrated that paradoxical sleep deprivation (PSD) was effective in inducing penile erection (PE) in 60% of 22-month-old PSD rats after acute cocaine ...

    • Amnestic effect of cocaine after the termination of its stimulant action 

      Niigaki, S. T. [UNIFESP]; Silva, R. H.; Patti, C. L. [UNIFESP]; Cunha, J. L. S. [UNIFESP]; Kameda, S. R. [UNIFESP]; Correia-Pinto, J. C. [UNIFESP]; Takatsu-Coleman, A. L. [UNIFESP]; Levin, R. [UNIFESP]; Abilio, V. C. [UNIFESP]; Frussa-Filho, R. [UNIFESP] (Elsevier B.V., 2010-02-01)
      The effects of cocaine on memory are controversial. Furthermore, the psychostimulant action of cocaine can be a critical issue in the interpretation of its effects on learning/memory models. the effects of a single ...

    • Association of paradoxical sleep deprivation and ecstasy (MDMA) enhances genital reflexes in male rats 

      Andersen, Monica Levy [UNIFESP]; Perry, Juliana Cini [UNIFESP]; Battisti, Murilo Campos [UNIFESP]; Calzavara, Mariana Bendlin [UNIFESP]; Costa, José Luiz da; Negrini Neto, Osvaldo; Frussa-Filho, Roberto [UNIFESP]; Tufik, Sergio[UNIFESP] (Elsevier B.V., 2006-06-30)
      Ecstasy ((+/-)3,4-methylenedioxymethamphetamine, MDMA) is a psychostimulant and a synthetic derivative of amphetamine that, according to its consumers, promotes the enhancement of sexual pleasure. This study sought to ...

    • Avaliação de eficácia do manejo de contingências no tratamento ambulatorial padrão para indivíduos com diagnóstico de dependência por crack 

      Miguel, Andre de Queiroz Constantino [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2016-06-24)
      Introduction: Crack dependence has become a severe public health problem in Brazil. It estimated that over one million Brazilians (0.8% of the population) have smoked crack in the last year, making Brazil world?s biggest ...

    • Avaliação do transplante de células-tronco precursoras de neurônios inibitórios na amígdala basolateral em camundongos tratados com cocaína na ansiedade e na preferência condicionada por lugar e suas correlações neurobiológicas 

      Yokoyama, Thais Suemi [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2017-06-29)
      Drug addiction is one of the main problems modern society, as it can affect several areas of society, economy and public health. Studies have shown that in addition to the pharmacological effects of drugs of abuse, the ...

    • Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys 

      Banks, Matthew L.; Andersen, Monica L. [UNIFESP]; Murnane, Kevin S.; Meyer, Rebecca C.; Howell, Leonard L. (Springer, 2009-08-01)
      Diphenhydramine (DPH) is an over-the-counter medication used in the treatment of allergic symptoms. While DPH abuse is infrequent, recent preclinical evidence suggests that DPH and cocaine combinations may have enhanced ...