Now showing items 1-10 of 13

    • Aspectos Moleculares Envolvidos Na Nefrotoxicidade Induzida Pela Cisplatina 

      Estrela, Gabriel Rufino [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2017-05-31)
      Cisplatin is one of the antitumor agents most commonly used in chemotherapy, but nephrotoxicity is frequent and one of the limitations of its use. There are several mechanisms that contribute to renal dysfunction following ...

    • Cancer treatment in determination of hearing loss 

      de Oliveira, Priscila Feliciano; Oliveira, Camila Silva; Andrade, Joice Santos; do Carmo Santos, Tamara Figueiredo; de Oliveira-Barreto, Aline Cabral [UNIFESP] (Assoc brasileira otorrinolaringologia & cirurgia cervicofacial, 2016)
      Introduction: Chemotherapy and radiotherapy in oncology have repercussions in hearing health, and can damage structures of the inner ear. These repercussions usually, result in a bilateral and irreversible hearing loss. ...

    • Eficácia da dexametasona intratimpânica como otoprotetor em pacientes submetidos à cisplatina 

      Salmito, Marcio Cavalcante [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2020-10-05)
      Cisplatin is a highly effective antitumor agent, but its use is limited by its side effects, including ototoxicity, nephrotoxicity and myelosuppression. The objective of this study is to evaluate the possible otoprotective ...

    • Estudo Da Autofagia E Dos Mecanismos De Morte Após Privação Nutricional Para Quimiosensibilização De Modelos De Melanoma Humano Wild Type E Braf V600e 

      Antunes, Fernanda [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2018-06-28)
      Metastatic Melanoma Remains One Of The Most Aggressive And Invasive Human Malignancies, With High Resistance To The Treatments Nowadays Available. New Effective Therapeutic Approaches Are Therefore Urgently Needed To Treat ...

    • Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice 

      Damiao, Marcio Jose [UNIFESP]; Giannocco, Gisele [UNIFESP]; Grespan, Renata; Silva, Expedito Leite; Duarte, Janaina S. [UNIFESP]; Maciel, Rui Monteiro de Barros [UNIFESP]; Yamada, Alcileia Nunes; Bersani-Amado, Ciomar Aparecida; Cuman, Roberto Kenji Nakamura (Pharmacotherapy Group, 2013-12-01)
      Purpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), ...

    • Kinin B-2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury 

      Estrela, Gabriel R. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Bacurau, Reury Frank Pereira; Malheiros, Denise M. A. C.; Camara, Niels O. S.; Araujo, Ronaldo C. [UNIFESP] (Elsevier B.V., 2014-09-01)
      Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the ...

    • Kinin B1 receptor deficiency attenuates cisplatin-induced acute kidney injury by modulating immune cell migration 

      Estrela, Gabriel R. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Almeida, Danilo C. [UNIFESP]; Amano, Mariane T.; Castoldi, Angela; Dias, Carolina C. [UNIFESP]; Malheiros, Denise M. A. C.; Almeida, Sandro S. [UNIFESP]; Paredes-Gamero, Edgar J. [UNIFESP]; Pesquero, Joao B. [UNIFESP]; Barros, Carlos C. [UNIFESP]; Camara, Niels O. S.; Araujo, Ronaldo C. [UNIFESP] (Springer, 2014-04-01)
      Cisplatin is a chemotherapeutic agent that causes severe renal dysfunction. the kinin B1 receptor has been associated with the migration of immune cells to injured tissue as well as with renal inflammation. To examine the ...

    • Nutritional shortage augments cisplatin-effects on murine melanoma cells 

      Antunes, F. [UNIFESP]; Pereira, G. J. [UNIFESP]; Jasiulionis, M. G. [UNIFESP]; Bincoletto, C. [UNIFESP]; Smaili, S. S. [UNIFESP] (Elsevier Ireland Ltd, 2018)
      Melanoma incidence increases every year worldwide and is responsible for 80% of skin cancer deaths. Due to its metastatic potential and resistance to almost any treatments such as chemo, radio, immune and targeted-therapy, ...

    • Ototoxicity evaluation in medulloblastoma patients treated with involved field boost using intensity-modulated radiation therapy (IMRT): a retrospective review 

      Vieira, Wilson Albieri; Weltman, Eduardo; Chen, Michael Jenwei; Silva, Nasjla Saba da [UNIFESP]; Cappellano, Andrea Maria [UNIFESP]; Pereira, Liliane Desgualdo [UNIFESP]; Gonçalves, Maria Inês Rebelo [UNIFESP]; Ferrigno, Robson; Hanriot, Rodrigo Morais; Nadalin, Wladimir; Odone Filho, Vicente; Petrilli, Antonio Sergio [UNIFESP] (Biomed Central Ltd, 2014-07-21)
      Background: Ototoxicity is a known side effect of combined radiation therapy and cisplatin chemotherapy for the treatment of medulloblastoma. the delivery of an involved field boost by intensity modulated radiation therapy ...

    • O Papel Do Acetato Como Modulador Da Lesão Renal Aguda Induzida Por Cisplatina 

      Cruz, Mario Costa [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2017-12-20)
      Bacterial fermentation metabolites have increasingly been associated with systemic immune-inflammatory responses, besides their involvement in diseases such as cancer, obesity, diabetes and kidney damage. Recent evidence ...