Browsing by Subject "Cell therapy"

Now showing items 1-10 of 12

    • A comparison of the reparative and angiogenic properties of mesenchymal stem cells derived from the bone marrow of BALB/c and C57/BL6 mice in a model of limb ischemia 

      Cunha, Flavia Franco [UNIFESP]; Martins, Leonardo [UNIFESP]; Martin, Priscila Keiko Matsumoto [UNIFESP]; Stilhano, Roberta Sessa [UNIFESP]; Han, Sang Won [UNIFESP] (Biomed Central Ltd, 2013-07-26)
      Introduction: BALB/c mice and C57/BL6 mice have different abilities to recover from ischemia. C57/BL6 mice display increased vessel collateralization and vascular endothelial growth factor expression with a consequent rapid ...

    • Contamination of Mesenchymal Stem-Cells with Fibroblasts Accelerates Neurodegeneration in an Experimental Model of Parkinson's Disease 

      Pereira, Márcia Cristina Leite [UNIFESP]; Secco, Mariane; Suzuki, Daniela Emi [UNIFESP]; Janjoppi, Luciana [UNIFESP]; Rodini, Carolina Oliveira [UNIFESP]; Torres, Laila Brito [UNIFESP]; Araujo, Bruno Henrique Silva [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Zatz, Mayana; Okamoto, Oswaldo Keith [UNIFESP] (Humana Press Inc, 2011-11-01)
      Pre-clinical studies have supported the use of mesenchymal stem cells (MSC) to treat highly prevalent neurodegenerative diseases such as Parkinson's disease (PD) but preliminary trials have reported controversial results. ...

    • Effect of the bone marrow cell transplantation on elevated plus-maze performance in hippocampal-injured mice 

      Cruz e Alves-de-Moraes, Luis Bruno da; Ribeiro-Paes, Joao Tadeu; Longo, Beatriz Monteiro [UNIFESP]; Ferrazoli, Eneas Galdini [UNIFESP]; Carneiro Spera de Andrade, Telma Goncalves (Elsevier B.V., 2013-07-01)
      Several reports have shown that the hippocampus plays an important role in different aspects of the emotional control. There is evidence that lesions in this structure cause behavioral disinhibition, with reduction of ...

    • Grafting of GABAergic precursors rescues deficits in hippocampal inhibition 

      Calcagnotto, Maria E.; Zipancic, Ivan; Piquer-Gil, Marina; Mello, Luiz E. [UNIFESP]; Alvarez-Dolado, Manuel (Wiley-Blackwell, 2010-01-01)
      P>gamma-Aminobutyric acid (GABA) has an important role in the mechanism of epilepsy. Cell grafts from different sources have been performed to modulate local circuits or increase GABAergic inhibition in animal models of ...

    • High-fat diet increases STAT-3 and c-Myc expression and induces VEGF production in hone marrow mesenchymal stem cells in a rat model 

      do Carmo, Luciana Simao; de Oliveira, Dalila Cunha; Cortez, Mayara; Nogueira-Pedro, Amanda [UNIFESP]; Paredes-Gamero, Edgar Julian [UNIFESP]; Borelli, Primavera; Rogero, Marcelo Macedo; Fock, Ricardo Ambrosio (Natl Inst Science Communication-Niscair, 2017)
      Excessive intake of a high-fat diet (HFD) results in overweight, obesity and the development of insulin resistance, adipose tissue macrophage infiltration and significant increases in inflammatory biomarkers. Bone marrow ...

    • Immunomodulatory and neuroprotective effect of cryopreserved allogeneic mesenchymal stem cells on spinal cord injury in rats 

      Rosado, I. R.; Carvalho, P. H.; Alves, E. G. L.; Tagushi, T. M.; Carvalho, J. L.; Silva, J. F.; Lavor, M. S. L.; Oliveira, K. M. [UNIFESP]; Serakides, R.; Goes, A. M.; Melo, E. G. (Funpec-Editora, 2017)
      This study aimed to evaluate the immunomodulatory and neuroprotective effects of allogeneic and cryopreserved mesenchymal stem cells (MSCs) on spinal cord injury. A total of 120 rats were distributed into the following ...

    • Mesenchymal stem cells and chronic renal artery stenosis 

      Oliveira-Sales, Elizabeth Barbosa de [UNIFESP]; Boim, Mirian Aparecida [UNIFESP] (Amer Physiological Soc, 2016)
      Renal artery stenosis is the main cause of renovascular hypertension and results in ischemic nephropathy characterized by inflammation, oxidative stress, microvascular loss, and fibrosis with consequent functional failure. ...

    • Mesenchymal stem cells from sternum: the type of heart disease, ischemic or valvular, does not influence the cell culture establishment and growth kinetics 

      Dias, Lucinara Dadda; Casali, Karina Rabello [UNIFESP]; Ghem, Carine; da Silva, Melissa Kristocheck; Sausen, Grasiele; Palma, Patricia Bonini; Covas, Dimas Tadeu; Kalil, Renato A. K.; Schaan, Beatriz D.; Nardi, Nance Beyer; Markoski, Melissa Medeiros (Biomed Central Ltd, 2017)
      Background: In an attempt to increase the therapeutic potential for myocardial regeneration, there is a quest for new cell sources and types for cell therapy protocols. The pathophysiology of heart diseases may affect ...

    • Refractory Angina Cell Therapy (ReACT) Involving Autologous Bone Marrow Cells in Patients Without Left Ventricular Dysfunction: A Possible Role for Monocytes 

      Hossne, Nelson Americo [UNIFESP]; Invitti, Adriana Luckow; Buffolo, Enio [UNIFESP]; Azevedo, Silvia; Oliveira, José Salvador Rodrigues de [UNIFESP]; Stolf, Noedir Groppo; Cruz, L. Eduardo; Sanberg, Paul R. (Cognizant Communication Corp, 2009-01-01)
      Autologous bone marrow mononuclear cell (BMMC) transplantation has emerged as a potential therapeutic option for refractory angina patients. Previous studies have shown conflicting myocardium reperfusion results. the present ...

    • Sangue de cordão umbilical para uso autólogo ou grupo de pacientes especiais 

      Cruz, Luis Eduardo; Jorge, Maria Claudia; Machado, Janaína J.; Hossne Junior, Nelson Americo [UNIFESP]; Invitti, Adriana L.; Balduino, Alex; Vianna, Verônica; Ellovitch, Saada R. S.; Urago, Kátia P. T.; Meneses-Costa, Ana Paula; Ribeiro, Márcia G.; Nicola, Maria Helena A.; Sanberg, Paul R. (Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2009-05-01)
      Umbilical Cord Blood is a rich source of hematopoietic stem cells widely used as a substitute of bone marrow (BM) in transplants. Cells from umbilical cord blood present advantages over BM cells, mainly as they are younger ...