Now showing items 1-5 of 5

    • Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma 

      Nascimento, Fabricio P. [UNIFESP]; Cardoso, Mirian G. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Kunii, Ilda S. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Kizys, Marina M. L. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP] (Spandidos Publ Ltd, 2016)
      Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ...

    • Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma 

      Nascimento, Fabricio P. [UNIFESP]; Cardoso, Mirian G. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Kunii, Ilda S. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Kizys, Marina M. L. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP] (Spandidos Publ Ltd, 2016)
      Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ...

    • Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma 

      Puig, Susana; Potrony, Miriam; Cuellar, Francisco; Puig-Butille, Joan Anton; Carrera, Cristina; Aguilera, Paula; Nagore, Eduardo; Garcia-Casado, Zaida; Requena, Celia; Kumar, Rajiv; Landman, Gilles [UNIFESP]; Soares de Sa, Bianca Costa; Rezze, Gisele Gargantini; Facure, Luciana; Ribeiro de Avila, Alexandre Leon; Achatz, Maria Isabel; Carraro, Dirce Maria; Duprat Neto, Joao Pedreira; Grazziotin, Thais C.; Bonamigo, Renan R.; Rey, Maria Carolina W.; Balestrini, Claudia; Morales, Enrique; Molgo, Montserrat; Bakos, Renato Marchiori; Ashton-Prolla, Patricia; Giugliani, Roberto; Borges, Alejandra Larre; Barquet, Virginia; Perez, Javiera; Martinez, Miguel; Cabo, Horacio; Sabban, Emilia Cohen; Latorre, Clara; Carlos-Ortega, Blanca; Salas-Alanis, Julio C.; Gonzalez, Roger; Olazaran, Zulema; Malvehy, Josep; Badenas, Celia (Nature Publishing Group, 2016)
      Purpose: CDKN2A is the main high-risk melanoma-susceptibility gene, but it has been poorly assessed in Latin America. We sought to analyze CDKN2A and MC1R in patients from Latin America with familial and sporadic multiple ...

    • Germline CDKN2A mutations in Brazilian patients of hereditary cutaneous melanoma 

      Ribeiro de Avila, Alexandre Leon; Victorino Krepischi, Ana Cristina; Moredo, Luciana Facure; Marques Aguiar, Talita Ferreira; Silva, Felipe Carneiro da; Soares de Sa, Bianca Costa; Nobrega, Amanda Franca de; Waddington Achatz, Maria Isabel; Duprat, Joao Pedreira; Landman, Gilles [UNIFESP]; Carraro, Dirce Maria (Springer, 2014-12-01)
      Approximately 10 % of all cutaneous melanoma cases occur in a familial context. the major susceptibility gene for familial melanoma is CDKN2A. in Latin America, genetic studies investigating melanoma predisposition are ...

    • Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer 

      Lima, Eleonidas Moura; Leal, Mariana Ferreira [UNIFESP]; Burbano, Rommel Rodríguez [UNIFESP]; Khayat, Andre Salim; Assumpção, Paulo Pimentes de [UNIFESP]; Bello, Maria Jose; Rey, J.a.; Smith, Marilia de Arruda Cardoso [UNIFESP]; Casartelli, Carla (Associação Brasileira de Divulgação Científica, 2008-06-01)
      Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer death worldwide. DNA methylation is the most studied epigenetic alteration, occurring through a methyl radical addition to the ...