Browsing by Subject "Bothrops jararaca"

Angiotensin-degrading serine peptidase: A new chymotrypsin-like activity in the venom of Bothrops jararaca partially blocked by the commercial antivenom

Kuniyoshi, Alexandre Kazuo; Rocha, Marisa; Carvalho, Daniela Cajado; Juliano, Maria Aparecida [UNIFESP]; Juliano, Luiz [UNIFESP]; Tambourgi, Denise Vilarinho; Portaro, Fernanda Calheta Vieira [UNIFESP] (Elsevier B.V., 2012-01-01)

Snakebite envenomation is considered a highly relevant public health hazard in South America, having an impact in terms of mortality and morbidity. in Brazil, Bothrops (sensu latu) poisoning is responsible for 90% of the ...

The anti-inflammatory action of Bothrops jararaca snake antithrombin on acute inflammation induced by carrageenan in mice

Morais-Zani, Karen de; Barbosa Nunes, Fernanda Peixoto; Silva, Jacilene Barbosa da; Ferreira, Marcio Jose; Grego, Kathleen Fernandes; Lopes-Ferreira, Monica; Tanaka, Aparecida Sadae [UNIFESP]; Tanaka-Azevedo, Anita Mitico (Springer, 2013-08-01)

Antithrombin is known as the most important natural coagulation inhibitor and has been shown to have anti-inflammatory properties. the present study aimed to investigate the effects of Bothrops jararaca antithrombin on ...

Bothrops jararaca antithrombin: Isolation, characterization and comparison with other animal antithrombins

Morais, Karen Batista de; Vieira, Carolina Okamoto; Hirata, Izaura Yoshico [UNIFESP]; Tanaka-Azevedo, Anita Mitico (Elsevier B.V., 2009-02-01)

Antithrombin was purified from Bothrops jararaca plasma by affinity chromatography using HiTrap Heparin HP column, and its molecular weight, amino-terminal sequence, carbohydrate content, isoelectric point, inhibition of ...

Bothrops jararaca fibrinogen and its resistance to hydrolysis evoked by snake venoms

Vieira, Carolina O.; Tanaka, Aparecida S. [UNIFESP]; Sano-Martins, Ida S.; Morais, Karen B.; Santoro, Marcelo L.; Tanaka-Azevedo, Anita M. (Elsevier B.V., 2008-12-01)

Fibrinogen is an essential protein involved in several steps of hemostasis, being associated with the final steps of the blood coagulation mechanism. Herein, we describe the purification and characterization of a reptile ...

Characterization of Bothrops jararaca coagulation inhibitor (BjI) and presence of similar protein in plasma of other animals

Tanaka-Azevedo, A. M.; Torquato, RJS; Tanaka, A. S.; Sano-Martins, I. S. (Elsevier B.V., 2004-09-01)

BjI, a protein isolated from Bothrops jararaca snake blood, inhibits the coagulant activity of thrombin. This protein presents two bands of 109 and 138 kDa by SDS-PAGE under reducing conditions. in order to verify the ...

Differential transcript profile of inhibitors with potential anti-venom role in the liver of juvenile and adult Bothrops jararaca snake

Gomes, Cicera Maria; de Morais-Zani, Karen [UNIFESP]; Lu, Stephen [UNIFESP]; Buarque, Diego de Souza [UNIFESP]; Cardoso Braz, Gloria Regina; Grego, Kathleen Fernandes; Tanaka, Aparecida Sadae [UNIFESP]; Tanaka-Azevedo, Anita Mitico (Peerj Inc, 2017)

Background. Snakes belonging to the Bothrops genus are vastly distributed in Central and South America and are responsible for most cases of reported snake bites in Latin America. The clinical manifestations of the ...

Enhancement of the citrulline-nitric oxide cycle in astroglioma cells by the proline-rich peptide-10c from Bothrops jararaca venom

Oliveira, Eduardo Fontana de [UNIFESP]; Guerreiro, Juliano R.; Silva, Carlos A.; Souza Benedetti, Gabriel Fernando de [UNIFESP]; Lebrun, Ivo; Ulrich, Henning; Lameu, Claudiana; Camargo, Antonio C. M. (Elsevier B.V., 2010-12-06)

The biological activity of the proline rich decapeptde Bj PRO 10c a processing product of the C type natriuretic peptide precursor protein, expressed in the brain and the venom gland of the pit viper Bothrops jararaca, was ...