Now showing items 1-10 of 22

    • Alteration in Ikaros expression promotes B-1 cell differentiation into phagocytes 

      de Oliveira, Vivian Cristina [UNIFESP]; Pires Sodre, Ana Clara [UNIFESP]; Gomes, Caio Perez [UNIFESP]; Moretti, Nilmar Silvio [UNIFESP]; Pesquero, Joao Bosco; Popi, Ana Flavia [UNIFESP] (Elsevier Gmbh, Urban & Fischer Verlag, 2018)
      Ikaros is a broad transcription factor pointed as a critical regulator of lymphocyte development. Recent reports have emphasized that distinct isoforms of Ikaros control the dichotomy of the hematopoietic system into ...

    • B-1 cell participation in T-cell-mediated alloimmune response 

      Nogueira-Martins, Mauro F. [UNIFESP]; Mariano, Mario [UNIFESP] (Elsevier B.V., 2010-04-01)
      B-1 and B cells are important producers of natural antibodies in mice and humans and, therefore, are considered as the first line of defense against pathogens. Because of that, their role in T-cell-mediated immune responses ...

    • B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties 

      Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Acad Brasileira De Ciencias, 2009-09-01)
      Characterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse ...

    • B-1 cells and concomitant immunity in Ehrlich tumour progression 

      Azevedo, M. C. [UNIFESP]; Palos, M. C. [UNIFESP]; Osugui, L. [UNIFESP]; Laurindo, M. F. [UNIFESP]; Masutani, D. [UNIFESP]; Nonogaki, S. [UNIFESP]; Bachi, Andre Luis Lacerda [UNIFESP]; Melo, F. H. M. [UNIFESP]; Mariano, M. [UNIFESP] (Elsevier B.V., 2014-05-01)
      Concomitant immunity is a phenomenon in which a tumour-bearing host is resistant to the growth of an implanted secondary tumour. Metastases are considered to be secondary tumours that develop spontaneously during primary ...

    • B-1 cells are pivotal for in vivo inflammatory giant cell formation 

      Bogsan, CSB; Brito, RRNE; Palos, M. D.; Mortara, R. A.; Almeida, SR; Lopes, J. D.; Mariano, M. (Blackwell Publishing, 2005-08-01)
      The mechanisms that govern giant cell (GC) formation in inflammatory, neoplastic and physiologic conditions are far from being understood. Here, we demonstrate that B-1 cells are essential for foreign-body GC formation in ...

    • B-1 cells facilitate Paracoccidioides brasiliensis infection in mice via IL-10 secretion 

      Popi, Ana Flavia [UNIFESP]; Godoy, Luiz Claudio [UNIFESP]; Xander, Patricia [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Elsevier B.V., 2008-06-01)
      Protective immunity in paracoccidioidomycosis is mainly mediated by cellular immunity. the role of B cells in this disease, in particular B-1 cells, is poorly understood. the aim of this study was to characterize the ...

    • B-1 cells modulate oral tolerance in mice 

      De-Gennaro, Luiz Antonio [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Almeida, Sandro Rogrio de; Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Elsevier B.V., 2009-06-04)
      Although the origin and functions of B-1 cells are controversial, they are considered as a cellular element of innate immunity due to their ability to produce natural autoantibodies of the IgM type. These antibodies are ...

    • B-1 cells modulate the kinetics of wound-healing process in mice 

      Oliveira, H. C. [UNIFESP]; Popi, A. F. [UNIFESP]; Bachi, Andre Luis Lacerda [UNIFESP]; Nonogaki, S.; Lopes, J. D. [UNIFESP]; Mariano, M. [UNIFESP] (Elsevier B.V., 2010-03-01)
      Wound healing is a complex phenomenon whose mechanisms are not fully understood. Although inflammatory cells are recruited to the site of the lesion there are no reports concerning the participation of B lymphocytes in ...

    • B-1 cells produce insulin and abrogate experimental streptozotocin-induced diabetes 

      Alvares-Saraiva, Anuska M. [UNIFESP]; Novo, Marilia C. T. [UNIFESP]; Oliveira, Vivian Cristina de [UNIFESP]; Maricato, Juliana Terzi [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Mariano, Mario [UNIFESP] (Wiley-Blackwell, 2015-05-01)
      The participation of B-1 cells in a murine model of spontaneous diabetes has been recently reported. Here, we describe the role of B-1 cells in streptozotocin (STZ) induced diabetes in mice. We demonstrated that XID (B-1 ...

    • B16 melanoma cells increase B-1 cell survival, IL-10 production and radioresistance in vitro 

      Lucatelli Laurindo, Maria Fernanda [UNIFESP]; Thies, Felipe Garutti [UNIFESP]; Perez, Elizabeth Cristina [UNIFESP]; Novaes e Brito, Ronni Romulo [UNIFESP]; Mariano, Mario [UNIFESP]; Popi, Ana Flavia [UNIFESP] (Elsevier B.V., 2013-04-01)
      B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. the role of both cell populations ...