Now showing items 1-10 of 16

    • Autoimmunity in Hyper-IgM syndrome 

      Jesus, Adriana A.; Duarte, Alberto J. S.; Oliveira, Joao B. (Springer, 2008-05-01)
      Introduction Immunodeficiency with hyper-IgM (HIGM) results from genetic defects in the CD40-CD40 ligand (CD40L) pathway or in the enzymes required for immunoglobulin class switch recombination and somatic hypermutation. ...

    • Avaliação fenotípica das células T reguladoras CD4+CD25+CD127LOW em pacientes com lúpus eritematoso sistêmico 

      Mesquita Júnior, Danilo [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2009-04-29)
      Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that is part of the group of rheumatic autoimmune inflammatory diseases, being characterized by heterogeneous clinical and laboratory manifestations. The ...

    • Different MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-beta in mice CNS despite unchanged clinical course 

      Dias, Alyria Teixeira; Ribeiro De Castro, Sandra Bertelli; De Souza Alves, Caio Cesar; Mesquita, Felipe Pereira; Visona De Figueiredo, Nathalia Stela; Evangelista, Marcilene Gomes; Marques Nogueira Castanon, Maria Christina; Juliano, Maria Aparecida [UNIFESP]; Ferreira, Ana Paula (Elsevier B.V., 2015-02-01)
      Multiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody ...

    • Doença de addison de etiologia auto-imune 

      Silva, Regina do Carmo [UNIFESP]; Kater, Claudio Elias [UNIFESP] (Sociedade Brasileira de Endocrinologia e Metabologia, 1998-12-01)
      Autoimmune Addison's disease is a rare and potentially, fatal endocrinopathy, that can occur either isolated or as part of the types I and II polyglandular autoimmune syndromes (PAS). Adrenocortical autoantibodies are ...

    • Effects of acute aerobic exercise on leukocyte inflammatory gene expression in systemic lupus erythematosus 

      Perandini, L. A.; Sales-de-Oliveira, Diego; Almeida, D. C. [UNIFESP]; Azevedo, Hatylas; Moreira-Filho, C. A.; Cenedeze, Marco Antonio [UNIFESP]; Benatti, F. B.; Lima, F. R.; Borba, Eduardo; Bonfa, E.; Sa-Pinto, A. L.; Roschel, H.; Camara, N. O.; Gualano, B. (Centro Federal Educacao Tecnologica Rio Grande Norte, 2016)
      Systemic lupus erythematosus (SLE) is an autoimmune disease with a persistent systemic inflammation. Exercise-induced inflammatory response in SLE remains to be fully elucidated. The aim of this study was to assess the ...

    • Gene Expression in B-1 Cells from Lupus-Prone Mice 

      Novaes e Brito, Ronni Romulo [UNIFESP]; Xander, Patricia [UNIFESP]; Perez, Elizabeth C. [UNIFESP]; Maricato, Juliana Terzi [UNIFESP]; Laurindo, Maria Fl. [UNIFESP]; De Lorenzo, Beatriz H. P. [UNIFESP]; Pellegrino, Renata [UNIFESP]; Bernardo, Viviane [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Informa Healthcare, 2014-01-01)
      New Zealand Black X New Zealand White F1 [(NZB/NZW) F1] mice develop an autoimmune condition with similarities to human systemic lupus erythematosus (SLE). in this study, we demonstrate that B-1 cells, which have previously ...

    • Humoral autoimmune response heterogeneity in the spectrum of primary biliary cirrhosis 

      Dellavance, Alessandra [UNIFESP]; Cancado, Eduardo Luiz Rachid; Abrantes-Lemos, Clarice Pires; Harriz, Michelle [UNIFESP]; Marvulle, Valdecir [UNIFESP]; Andrade, Luiz Eduardo Coelho [UNIFESP] (Springer, 2013-06-01)
      To compare autoantibody features in patients with primary biliary cirrhosis (PBC) and individuals presenting antimitochondria antibodies (AMAs) but no clinical or biochemical evidence of disease.A total of 212 AMA-positive ...

    • Immunologic derangement preceding clinical autoimmunity 

      Dellavance, A.; Coelho Andrade, L. E. [UNIFESP] (Sage Publications Ltd, 2014-10-01)
      Autoantibodies are valuable markers for the recognition of autoimmune diseases. Over the last 25 years, several investigators have consistently shown that autoantibodies precede the clinical onset of cognate diseases by ...

    • International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies 

      Agmon-Levin, Nancy; Damoiseaux, Jan; Kallenberg, Cees; Sack, Ulrich; Witte, Torsten; Herold, Manfred; Bossuyt, Xavier; Musset, Lucille; Cervera, Ricard; Plaza-Lopez, Aresio; Dias, Carlos; Sousa, Maria Jose; Radice, Antonella; Eriksson, Catharina; Hultgren, Olof; Viander, Markku; Khamashta, Munther; Regenass, Stephan; Coelho Andrade, Luis Eduardo [UNIFESP]; Wiik, Allan; Tincani, Angela; Ronnelid, Johan; Bloch, Donald B.; Fritzler, Marvin J.; Chan, Edward K. L.; Garcia-De la Torre, I.; Konstantinov, Konstantin N.; Lahita, Robert; Wilson, Merlin; Vainio, Olli; Fabien, Nicole; Sinico, Renato Alberto; Meroni, Pierluigi; Shoenfeld, Yehuda (Bmj Publishing Group, 2014-01-01)
      Anti-nuclear antibodies (ANA) are fundamental for the diagnosis of autoimmune diseases, and have been determined by indirect immunofluorescence assay (IIFA) for decades. As the demand for ANA testing increased, alternative ...

    • Marcadores genéticos e auto-imunes do diabetes melito tipo 1: da teoria para a prática 

      Silva, Maria Elizabeth Rossi da; Mory, Denise [UNIFESP]; Davini, Elaine (Sociedade Brasileira de Endocrinologia e Metabologia, 2008-03-01)
      Type 1 A diabetes mellitus (T1AD) results from the autoimmune destruction of the insulin producing pancreatic beta-cells. The largest contribution to genetic susceptibility comes from several genes located in the major ...