Now showing items 1-7 of 7

    • The anti-inflammatory action of Bothrops jararaca snake antithrombin on acute inflammation induced by carrageenan in mice 

      Morais-Zani, Karen de; Barbosa Nunes, Fernanda Peixoto; Silva, Jacilene Barbosa da; Ferreira, Marcio Jose; Grego, Kathleen Fernandes; Lopes-Ferreira, Monica; Tanaka, Aparecida Sadae [UNIFESP]; Tanaka-Azevedo, Anita Mitico (Springer, 2013-08-01)
      Antithrombin is known as the most important natural coagulation inhibitor and has been shown to have anti-inflammatory properties. the present study aimed to investigate the effects of Bothrops jararaca antithrombin on ...

    • Bothrops jararaca antithrombin: Isolation, characterization and comparison with other animal antithrombins 

      Morais, Karen Batista de; Vieira, Carolina Okamoto; Hirata, Izaura Yoshico [UNIFESP]; Tanaka-Azevedo, Anita Mitico (Elsevier B.V., 2009-02-01)
      Antithrombin was purified from Bothrops jararaca plasma by affinity chromatography using HiTrap Heparin HP column, and its molecular weight, amino-terminal sequence, carbohydrate content, isoelectric point, inhibition of ...

    • Cloning, Characterization and Anti-Inflammatory Properties of Bothrops jararaca Snake Antithrombin 

      Morais-Zani, Karen de; Grego, Kathleen Fernandes; Torquato, Ricardo José Soares [UNIFESP]; Silva, Caroline Serino; Tanaka, Aparecida Sadae [UNIFESP]; Tanaka-Azevedo, Anita Mitico (Bentham Science Publ Ltd, 2015-01-01)
      Antithrombin inhibits blood coagulation through the interaction with serine proteases in both intrinsic and extrinsic pathways. In addition, antithrombin also shows anti-inflammatory properties, which are independent of ...

    • Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors 

      Gozzo, Andrezza Justino [UNIFESP]; Nunes, V.a. [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Dietrich, Carl Peter [UNIFESP]; Carmona, Adriana Karaoglanovic [UNIFESP]; Sampaio, Misako Uemura [UNIFESP]; Sampaio, C.a.m. [UNIFESP]; Araujo, Mariana da Silva [UNIFESP] (Associação Brasileira de Divulgação Científica, 2003-08-01)
      Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled ...

    • A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence 

      Chavante, Suely F.; Brito, Adriana S.; Lima, Marcelo [UNIFESP]; Yates, Edwin [UNIFESP]; Nader, Helena [UNIFESP]; Guerrini, Marco; Torri, Giangiacomo; Bisio, Antonella (Elsevier B.V., 2014-05-22)
      The detailed characterization of a novel heparin-like glycosaminoglycan purified from the viscera (heads) of the shrimp Litopenaeus vannamei is reported. Structural analysis performed by mono-and two-dimensional nuclear ...

    • A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential 

      Brito, Adriana S.; Cavalcante, Romulo S.; Palhares, Lais C. G. F.; Hughes, Ashley J.; Andrade, Giulianna P. V.; Yates, Edwin Alexander [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Lima, Marcelo Andrade de [UNIFESP]; Chavante, Suely F. (Elsevier B.V., 2014-01-02)
      The structural characterization and the anticoagulant potential of a novel heparin/heparan sulfate-like compound from the heads of Litopenaeus vannamei shrimp are described. While it is distinct from either heparin or ...

    • Polymorphisms in antithrombin and in tissue factor pathway inhibitor genes are associated with recurrent pregnancy loss 

      Guerra-Shinohara, Elvira M.; Bertinato, Juliano Felix; Bueno, Carolina Tosin; Silva, Kelma Cordeiro da; Burlacchini de Carvalho, Mario Henrique; Vieira Francisco, Rossana Pulcineli; Zugaib, Marcelo [UNIFESP]; Cerda, Alvaro; Morelli, Vania Maris [UNIFESP] (Schattauer Gmbh-verlag Medizin Naturwissenschaften, 2012-10-01)
      Recurrent pregnancy loss (RPL) is a multifactorial condition. the effect of antithrombin (SERPINC1), protein C (PROC), thrombomodulin (THBD) and tissue factor pathway inhibitor (TFPI) single nucleotide polymorphisms (SNPs) ...