Now showing items 1-10 of 14

    • ACE activity is modulated by the enzyme alpha-galactosidase A 

      Batista, Elice Carneiro; Carvalho, Luiz Roberto; Casarini, Dulce Elena [UNIFESP]; Carmona, Adriana Karaoglanovic; Santos, Edson Lucas dos; Silva, Elton Dias da; Santos, Robson Augusto dos; Nakaie, Clovis Ryuichi; Munoz Rojas, Maria Veronica; Oliveira, Suzana Macedo de; Bader, Michael; D'Almeida, Vania [UNIFESP]; Martins, Ana Maria [UNIFESP]; Souza, Kely de Picoly; Pesquero, Joao Bosco [UNIFESP] (Springer, 2011-01-01)
      Fabry disease is a multisystem X-linked disorder resulting from alpha-galactosidase A (alpha-GalA) gene mutations leading to the accumulation of globotriaosylceramide mainly in endothelium compromising heart, kidney, and ...

    • The adipose tissue and the involvement of the renin-angiotensin-aldosterone system in cardiometabolic syndrome 

      Borghi, F.; Sevá-Pessôa, Bruno [UNIFESP]; Grassi-Kassisse, D. M. (Springer, 2016)
      Cardiometabolic diseases are linked to a cluster of modifiable factors, including risk factors closely related to central adiposity. Chronic renin-angiotensin-aldosterone system (RAAS) activation has far-reaching effects ...

    • Altered mitochondrial function, calcium signaling, and catecholamine release in chromaffin cells of diabetic and SHR rats 

      Musial, Diego C. [UNIFESP]; Bomfim, Guilherme H. [UNIFESP]; Arranz-Tagarro, Juan A.; Mendez-Lopez, Iago; Miranda-Ferreira, Regiane [UNIFESP]; Jurkiewicz, Aron [UNIFESP]; Jurkiewicz, Neide H. [UNIFESP]; Garcia, Antonio G.; Padin, Juan F. (Elsevier Science Bv, 2017)
      Comorbidity of diabetes and hypertension is frequent. Here, we have performed a comparative study in three animal models namely, normotensive Wistar Kyoto (WKY) rats, streptozotocin-induced diabetic rats (STZ), and ...

    • A fluorimetric binding assay for angiotensin II and kinin receptors 

      Martin, Renan Paulo [UNIFESP]; Filippelli-Silva, Rafael [UNIFESP]; Rodrigues, Eliete da Silva [UNIFESP]; Nakaie, Clovis Ryuichi [UNIFESP]; Shimuta, Suma Imura [UNIFESP] (Elsevier Science Inc, 2016)
      Angiotensin II (AngII) and kinins (bradykinin (BK) and des-Arg9-bradykinin (DBK)), are potent agents involved in the maintenance of blood pressure and several biological activities, and their better understanding is important ...

    • Frequencia Do Polimorfismo (-1332g/A) No Gene Do Receptor At2 E Sua Eventual Associação Com O Câncer De Ovário 

      Cecato, Gabriela Zarate [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2018-06-28)
      The Renin Angiotensin System (Ars) Is Related To The Genesis And Maintenance Of Arterial Hypertension And Plays An Essential Role In Cardiovascular Balance. Angiotensin Ii Regulates A Number Of Physiological Responses In ...

    • Hepatic conversion of angiotensin I and the portal hypertensive response to angiotensin II in normal and regenerating liver 

      Carvalho, Leda Teixeira [UNIFESP]; Nascimento, Ecio Alves; Teixeira, Felipe de Oliveira [UNIFESP]; Nagaoka, Márcia Regina [UNIFESP]; Borges, Durval Rosa [UNIFESP]; Kouyoumdjian, Maria [UNIFESP] (Blackwell Publishing, 2007-09-01)
      Background and Aim: Angiotensin I (AI) and angiotensin II (AII) induce a portal hypertensive response (PHR) and the liver is able to convert AI into AII to trough the action of the angiotensin-converting enzyme (ACE). Our ...

    • Inhibition of phosphodiesterase 5 restores endothelial function in renovascular hypertension 

      Dias, Ananda T.; Cintra, Amanda S.; Frossard, Jessica C.; Palomino, Zaira [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Gomes, Isabele B. S.; Balarini, Camille M.; Gava, Agata L.; Campagnaro, Bianca P.; Pereira, Thiago M. C.; Meyrelles, Silvana S.; Vasquez, Elisardo C. (Biomed Central Ltd, 2014-09-16)
      Background: the clipping of an artery supplying one of the two kidneys (2K1C) activates the renin-angiotensin (Ang) system (RAS), resulting in hypertension and endothelial dysfunction. Recently, we demonstrated the intrarenal ...

    • Predisposition to atherosclerosis and aortic aneurysms in mice deficient in kinin B1 receptor and apolipoprotein E 

      Merino, Vanessa F. [UNIFESP]; Todiras, Mihail; Mori, Marcelo A. [UNIFESP]; Sales, Vicencia M. T. [UNIFESP]; Fonseca, Raphael G. [UNIFESP]; Saul, Vera; Tenner, Katja; Bader, Michael; Pesquero, Joao B. [UNIFESP] (Springer, 2009-10-01)
      Kinin B1 receptor is involved in chronic inflammation and expressed in human atherosclerotic lesions. However, its significance for lesion development is unknown. Therefore, we investigated the effect of kinin B1 receptor ...

    • Pulmonary kinin metabolism and conversion of angiotensin-i in spontaneously hypertensive rats 

      Pesquero, João Bosco [UNIFESP]; Boschcov, Paulo [UNIFESP]; Lindsey, Charles Julian [UNIFESP]; Paiva, Antonio Cechelli de Mattos [UNIFESP] (Rapid Science Publishers, 1992-12-01)
      Objective: To examine the metabolism of kinins and angiotensin I in the pulmonary circulation of spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NWR).Methods: Bradykinin inactivation was estimated in ...

    • Resveratrol inhibits the intracellular calcium increase and angiotensin/endothelin system activation induced by soluble uric acid in mesangial cells 

      Albertoni, Guilherme Ambrozio [UNIFESP]; Schor, Nestor [UNIFESP] (Associação Brasileira de Divulgação Científica, 2015-01-01)
      Resveratrol (Resv) is natural polyphenol found in grapes. This study evaluated the protective effect of Resv against the effects of uric acid (UA) in immortalized human mesangial cells (ihMCs). ihMCs were preincubated with ...