Browsing by Subject "Amblyomin-X"

Now showing items 1-9 of 9

    • Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell 

      Morais, Katia Luciano Pereira [UNIFESP]; Fernandes Pacheco, Mario Thiego; Berra, Carolina Maria; Bosch, Rosemary V.; Sciani, Juliana Mozer; Chammas, Roger [UNIFESP]; Saito, Renata de Freitas; Iqbal, Asif; Chudzinski-Tavassi, Ana Marisa [UNIFESP] (Springer, 2016)
      During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a Kunitz-type FXa inhibitor similar to ...

    • Avaliação Da Atividade Do Amblyomin-X Na Regulação Da Adesão E Migração De Células Endoteliais E Tumorais São Paulo, 

      Schmidt, Mariana Costa Braga [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2017-02-24)
      Amblyomin-X is a Kunitz-type protease inhibitor that promotes phospholipids-dependent inhibition of FXa, or inhibits the activation of FX through TF/FVlla complex. This recombinant protein shows similarity with Kunitz ...

    • Avaliação dos efeitos de um inibidor do tipo Kunitz (Amblyomin-X) em culturas celulares de carcinoma renal 

      Akagi, Erica Mie [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2011-10-27)
      The renal cell carcinoma (RCC) is currently a disease of great clinical interest. Its incidence is increasing, especially the incidental findings, which now represent 50% of new cases diagnosed. Because it is highly resistant ...

    • A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis 

      Ventura, Janaina Souza [UNIFESP]; Faria, Fernanda; Correia Batista, Isabel Fatima; Simons, Simone Michaela [UNIFESP]; Lourenco Oliveira, Daniella Gorete [UNIFESP]; Morais, Katia L. P. [UNIFESP]; Chudzinski-Tavassi, Ana Marisa [UNIFESP] (Elsevier B.V., 2013-04-01)
      Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. in this study was demonstrated that the Amblyomin-X (which is a recombinant protein that exerts similarity ...

    • A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production 

      Maria, Durvanei Augusto; Souza, Jean Gabriel de [UNIFESP]; Morais, Katia Luciano Pereira [UNIFESP]; Berra, Carolina Maria; Zampolli, Hamilton de Campos; Demasi, Marilene; Simons, Simone Michaela; Saito, Renata de Freitas; Chammas, Roger; Chudzinski-Tavassi, Ana Marisa [UNIFESP] (Springer, 2013-06-01)
      In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2 family protein regulation, the impairment of mitochondrial functions, ...

    • Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X 

      Pacheco, Mario T. F.; Morais, Katia L. P. [UNIFESP]; Berra, Carolina M.; Demasi, Marilene; Sciani, Juliana M.; Branco, Vania G.; Bosch, Rosemary V.; Iqbal, Asif; Chudzinski-Tavassi, Ana Marisa (Elsevier Inc, 2016)
      The Kunitz-type recombinant protein, Amblyomin-X, is an antitumor recombinant molecule from a cDNA library prepared from the salivary glands of the tick Amblyomma cajennense. The primary target of this protein appears to ...

    • Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X 

      Pacheco, Mario T. F.; Morais, Katia L. P. [UNIFESP]; Berra, Carolina M.; Demasi, Marilene; Sciani, Juliana M.; Branco, Vania G.; Bosch, Rosemary V.; Iqbal, Asif; Chudzinski-Tavassi, Ana Marisa (Elsevier Inc, 2016)
      The Kunitz-type recombinant protein, Amblyomin-X, is an antitumor recombinant molecule from a cDNA library prepared from the salivary glands of the tick Amblyomma cajennense. The primary target of this protein appears to ...

    • Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates 

      Chudzinski-Tavassi, Ana Marisa; Morais, Katia L. P. [UNIFESP]; Pacheco, Mario Thiego Fernandes; Pasqualoto, Kerly Fernanda Mesquita; de Souza, Jean Gabriel [UNIFESP] (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)
      Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its ...

    • Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates 

      Chudzinski-Tavassi, Ana Marisa; Morais, Katia L. P. [UNIFESP]; Pacheco, Mario Thiego Fernandes; Pasqualoto, Kerly Fernanda Mesquita; de Souza, Jean Gabriel [UNIFESP] (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)
      Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its ...