Now showing items 1-10 of 11

    • ANALYSIS of SNAP25 mRNA EXPRESSION and PROMOTER DNA METHYLATION in BRAIN AREAS of ALZHEIMER'S DISEASE PATIENTS 

      Furuya, T. K. [UNIFESP]; Silva, P. N. O. [UNIFESP]; Payao, S. L. M. [UNIFESP]; Bertolucci, P. H. F. [UNIFESP]; Rasmussen, L. T.; De Labio, R. W.; Braga, I. L. S. [UNIFESP]; Chen, E. S. [UNIFESP]; Turecki, G.; Mechawar, N.; Mill, J.; Smith, M. A. C. [UNIFESP] (Elsevier B.V., 2012-09-18)
      Alzheimer's Disease (AD) is the most common cause of dementia in elderly people. the presynaptic terminal is an important site of pathological changes in AD, leading to synaptic loss in specific brain regions, such as in ...

    • Associations of blood pressure with functional and cognitive changes in patients with alzheimer's disease 

      de Oliveira, Fabricio Ferreira [UNIFESP]; Chen, Elizabeth Suchi [UNIFESP]; Smith, Marilia Cardoso [UNIFESP]; Ferreira Bertolucci, Paulo Henrique [UNIFESP] (Consel Brasil Oftalmologia, 2016)
      Background: Midlife hypertension followed by late life hypotension resulting from neurodegeneration increases amyloidogenesis and tauopathy. Methods: Consecutive outpatients with late-onset Alzheimer's disease (AD) at ...

    • Avaliação da neuroproteção mediada pelo estrógeno em modelo celular de Tauopatia 

      Oliveira, Rafaela Brito [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2020-06-05)
      Recent studies have shown that the elderly population will continue to grow exponentially; therefore diseases associated with aging should be among the priorities for the development of new therapeutic management strategies. ...

    • Avaliação Do Transplante Cortical De Células-Tronco Mesenquimais Para Tratamento Da Doença De Alzheimer Em Modelo De Camundongos Transgênicos 

      Hukuda, Deborah Yamazaki [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2018-07-26)
      Aim: To Investigate The Effect Of Cortical Transplantation Of Mesenchymal Stem Cells (Msc) On The Physiopathology Of Alzheimer`S Disease (Ad). For This Purpose, We Evaluated Our Subjects During Different Stages Of The ...

    • Efeitos do exercício resistido e do transplante de células tronco mesenquimais em camundongos transgênicos para a doença de Alzheimer 

      Hashiguchi, Debora [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2019-10-31)
      Objective: In the present study, we analyzed the effects of the resistance exercise (RE) program or the bone-marrow mesenchymal stem cells (MSC) intra-hippocampal transplantation in the locomotor behavior, as well as amyloid ...

    • Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease 

      Vendramini, Alex Augusto; Lábio, Roger Willian de; Rasmussen, Lucas Trevizani [UNIFESP]; Reis, Nathali Mattiuzo dos [UNIFESP]; Minett, Thaís Soares Cianciarullo [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Pinhel, Marcela Augusta de Souza; Souza, Dorotéia Rossi Silva; Mazzotti, Diego Robles [UNIFESP]; Smith, Marilia de Arruda Cardoso [UNIFESP]; Payão, Spencer Luiz Marques [UNIFESP] (Sociedade Brasileira de Genética, 2011-01-01)
      An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of ...

    • Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches 

      Correa-Velloso, Juliana C.; Goncalves, Maria C. B. [UNIFESP]; Naaldijk, Yahaira; Oliveira-Giacomelli, Agatha; Pillat, Micheli M.; Ulrich, Henning (Pergamon-Elsevier Science Ltd, 2018)
      Neuropsychiatric disorders involve various pathological mechanisms, resulting in neurodegeneration and brain atrophy. Neurodevelopmental processes have shown to be critical for the progression of those disorders, which are ...

    • As relações entre diabetes, alzheimer e exercício físico: uma revisão bibliográfica 

      Nunes, Isadora Dariz [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2015-12-16)
      O presente estudo pretendeu mostrar as relações entre a doença de Alzheimer (DA), diabetes mellitus (DM) e o exercício físico, compreendendo seus mecanismos de desenvolvimento a partir de uma revisão bibliográfica. Foram ...

    • Repurposing of anti-diabetic agents for the treatment of cognitive impairment and mood disorders 

      Cha, D. S.; Vahtra, M.; Ahmed, J.; Kudlow, P. A.; Mansur, R. B. [UNIFESP]; Carvalho, A. F.; McIntyre, R. S. (Assoc Brasil Polimeros, 2016)
      Impairments in cognitive function represent a consistent, non-specific, and clinically significant feature in metabolic, mood, and dementing disorders. The foregoing observation is instantiated by evidence demonstrating ...

    • SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease 

      Furuya, Tatiane Katsue [UNIFESP]; Oliveira da Silva, Patricia Natalia [UNIFESP]; Payão, Spencer Luiz Marques [UNIFESP]; Rasmussen, Lucas Trevizani; Labio, Roger Willian de; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Braga, Ianna Lacerda Sampaio [UNIFESP]; Chen, Elizabeth Suchi [UNIFESP]; Turecki, Gustavo; Mechawar, Naguib; Mill, Jonathan; Smith, Marilia de Arruda Cardoso [UNIFESP] (Elsevier B.V., 2012-12-01)
      Alzheimer's Disease (AD) is a neurodegenerative disorder and the most common cause of dementia among the elderly. Efforts have been made to understand the genetic and epigenetic mechanisms involved in the development of ...