Now showing items 1-10 of 10

    • Bioprospecção de compostos inibidores da atividade catalítica de homólogos das enzimas conversoras de angiotensina (ECA 1 e ECA 2) de insetos e de mamíferos 

      Pederiva, Victoria Perini [UNIFESP] (Universidade Federal de São Paulo, 2022-07-29)
      Mosquitos transmissores de arboviroses (dengue, zika, chikungunya, febre amarela), ou de malária e filariose, têm apresentado resistência progressiva aos inseticidas sintéticos clássicos de baixa toxicidade humana. A (quase) ...

    • Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type inhibitor from Aedes aegypti with anticoagulant activity 

      Watanabe, Renata Midori Okuta [UNIFESP]; Tanaka-Azevedo, Anita M.; Araujo, Mariana da Silva [UNIFESP]; Juliano, Maria Aparecida [UNIFESP]; Tanaka, Aparecida Sadae [UNIFESP] (Elsevier B.V., 2011-03-01)
      Saliva of blood-sucking arthropods contains a complex mixture of anti-haemostatic, anti-inflammatory and immune-modulator compounds. Among anti-haemostatic factors, there are anticoagulants, vasodilators and platelet ...

    • Os ciclos do dengue em São Paulo e o modelo de intervenção 

      Matos, Marina Ruiz de [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2009-03-27)
      Este estudo utiliza o modelo ecológico para avaliar a situação epidemiológica do dengue no Estado de São Paulo de 1985 a 2005. Apresenta como discussão central as dificuldades de aplicação de um modelo de controle que prevê ...

    • Clonagem, expressão e caracterização de um inibidor de tripsina presente no mosquito Aedes aegypti 

      Watanabe, Renata Midori Okuta [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2010-02-24)
      The Aedes aegypti mosquito is the classic vector of yellow fever and dengue fever. In haematophagous insects, blood digestion is carried out by proteolitic enzymes, which can also be envolved in parasite-vector relationship. ...

    • The component of Carica papaya seed toxic to A-aegypti and the identification of tegupain, the enzyme that generates it 

      Nunes, Natalia Neto dos Santos [UNIFESP]; Santana, Lucimeire Aparecida de [UNIFESP]; Sampaio, Misako Uemura [UNIFESP]; Lemos, Francisco J. A.; Oliva, Maria Luiza Vilela [UNIFESP] (Elsevier B.V., 2013-07-01)
      As Aedes aegypti transmits the etiologic agents of both yellow and dengue fever; vector control is considered essential to minimise their incidence. the aim of this work was to identify the component of Carica papaya seed ...

    • Estudos moleculares de enzimas do tipo tripsina presentes no intestino médio de larvas de Aedes aegypti 

      Soares, Tatiane Sanches [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2009-07-29)
      Aedes aegypti is the most important vector of human arboviral diseases and it is responsible for dengue and urban yellow fever transmissions. Trypsin-like enzymes plays an important role in the Ae. aegypti adult and larval ...

    • Functional characterization of a serine protease inhibitor modulated in the infection of the Aedes aegypti with dengue virus 

      Soares, Tatiane Sanches [UNIFESP]; Rodriguez Gonzalez, Boris Luis [UNIFESP]; Soares Torquato, Ricardo Jose [UNIFESP]; Alves Lemos, Francisco Jose; Costa-da-Silva, Andre L.; Capurro Guimaraes, Margareth de Lara; Tanaka, Aparecida Sadae [UNIFESP] (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)
      During feeding with blood meal, female Aedes aegypti can transmit infectious agents, such as dengue, yellow fever, chikungunya and Zika viruses. Dengue virus causes human mortality in tropical regions of the world, and ...

    • High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti 

      Torquato, Ricardo J. S. [UNIFESP]; Lu, Stephen [UNIFESP]; Martins, Nadia Helena; Tanaka, Aparecida S. [UNIFESP]; Barbosa Pereira, Pedro Jose (Int Union Crystallography, 2017)
      Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a ...

    • A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity 

      Watanabe, Renata M. O. [UNIFESP]; Soares, Tatiane S. [UNIFESP]; Morais-Zani, Karen; Tanaka-Azevedo, Anita M.; Maciel, Ceres; Capurro, Margareth L.; Torquato, Ricardo J. S. [UNIFESP]; Tanaka, Aparecida S. [UNIFESP] (Elsevier B.V., 2010-08-01)
      Kazal-type inhibitors play several important roles in invertebrates, such as anticoagulant, vasodilator and antimicrobial activities. Putative Kazal-type inhibitors were described in several insect transcriptomes. in this ...

    • Triagem sorológica e influência do conhecimento sobre a dengue em pacientes do ambulatório de especialidades do SUS 

      Vilas Boas, Viviane Aparecida; Rocha, Katya Cristina; Oliveira, Claudia Giorgia Bronzatti De; Sant'anna, Aleksandra Vanessa Lambiasi; Azzalis, Ligia Ajaime [UNIFESP]; Beltrame, Registila Libânia; Junqueira, Virginia Berlanga Campos [UNIFESP]; Fonseca, Fernando Luiz Affonso [UNIFESP] (Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2011-04-01)
      INTRODUCTION: Dengue is a public health problem in Brazil and worldwide. OBJECTIVE: To determine dengue seropositivity of patients from SUS specialty laboratory by correlating the results with socio-demographic data. ...