Now showing items 1-9 of 9

    • Ascorbic acid reduces gentamicin-induced nephrotoxicity in rats through the control of reactive oxygen species 

      Moreira, Miriam A.; Nascimento, Marcos A.; Bozzo, Tatiana A.; Cintra, Alvaro [UNIFESP]; Silva, Sonia M. da [UNIFESP]; Dalboni, Maria Aparecida [UNIFESP]; Mouro, Margaret G.; Higa, Elisa M. S. [UNIFESP] (Churchill Livingstone, 2014-04-01)
      Background & aim: Oxidative stress has been implicated in the pathophysiology of many forms of acute renal failure. the aim was examine the effect of vitamin C on oxidative stress and its relationship with nitric oxide on ...

    • Collagen XVIII/endostatin expression in experimental endotoxemic acute renal failure 

      Cichy, Milene Cristina [UNIFESP]; Rocha, Flavia Gomes de Goes [UNIFESP]; Tristão, Vivian Regina [UNIFESP]; Pessoa, Edson de Andrade [UNIFESP]; Cenedeze, Marcos Antonio [UNIFESP]; Nürmberg Junior, R.; Schor, Nestor [UNIFESP]; Bellini, Maria Helena [UNIFESP] (Associação Brasileira de Divulgação Científica, 2009-12-01)
      Acute renal failure (ARF) is a frequent complication of Gram-negative sepsis, with a high risk of mortality. Lipopolysaccharide (LPS)-induced ARF is associated with hemodynamic changes that are strongly influenced by the ...

    • Contribution of CD4+ T cells to the early mechanisms of ischemia- reperfusion injury in a mouse model of acute renal failure 

      Pinheiro, Helady Sanders [UNIFESP]; Câmara, Niels Olsen Saraiva [UNIFESP]; Noronha, Irene Lourdes; Longo-Maugéri, Ieda Maria [UNIFESP]; Franco, Marcello Fabiano de [UNIFESP]; Medina, J.o.a.p. [UNIFESP]; Pacheco-Silva, Alvaro [UNIFESP] (Associação Brasileira de Divulgação Científica, 2007-04-01)
      Renal ischemia-reperfusion (IR) injury is the major cause of acute renal failure in native and transplanted kidneys. Mononuclear leukocytes have been reported in renal tissue as part of the innate and adaptive responses ...

    • Critical involvement of Th1-related cytokines in renal injuries induced by ischemia and reperfusion 

      Paiva, Vanessa Nunes de [UNIFESP]; Monteiro, Rebecca M. M. [UNIFESP]; Marques, Vilmar de Paiva; Cenedeze, Marcos Antonio [UNIFESP]; Teixeira, Vicente de P. A.; Reis, Marlene A. dos; Pacheco-Silva, Alvaro [UNIFESP]; Camara, Niels O. S. [UNIFESP] (Elsevier B.V., 2009-06-01)
      Renal ischemia and reperfusion injury (IRI) is considered an inflammatory syndrome. To move forward in its pathogenesis, we exploited the role of several cytokines on renal damages triggered by IRI. Specifically to evaluate ...

    • Early modulation of inflammation by mesenchymal stem cell after acute kidney injury 

      Semedo, Patricia [UNIFESP]; Palasio, Carolina G. [UNIFESP]; Oliveira, Cassiano D. [UNIFESP]; Feitoza, Carla Q. [UNIFESP]; Goncalves, Giselle M. [UNIFESP]; Cenedeze, Marcos Antonio [UNIFESP]; Wang, Pamella M. H. [UNIFESP]; Teixeira, Vicente P. A.; Reis, Marlene A.; Pacheco-Silva, Alvaro [UNIFESP]; Saraiva Camara, Niels Olsen [UNIFESP] (Elsevier B.V., 2009-06-01)
      Therapy with stem cells has showed to be promising for acute kidney injury (AKI), although how it works is still controversial. Modulation of the inflammatory response is one possible mechanism. Most of published data ...

    • Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats 

      Hosaka, E.m.; Santos, Oscar Fernando Pavão dos [UNIFESP]; Seguro, A.c.; Vattimo, M.f.f. (Associação Brasileira de Divulgação Científica, 2004-07-01)
      The frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme responsible for the synthesis ...

    • Incidence, risk factors and prognostic factors of acute renal failure in patients admitted to an intensive care unit 

      Mataloun, Sergio Elia [UNIFESP]; Machado, Flávia Ribeiro [UNIFESP]; Senna, Ana Paula Resque [UNIFESP]; Guimarães, Hélio Penna [UNIFESP]; Amaral, José Luiz Gomes do [UNIFESP] (Associação Brasileira de Divulgação Científica, 2006-10-01)
      The objective of the present study was to assess the incidence, risk factors and outcome of patients who develop acute renal failure (ARF) in intensive care units. In this prospective observational study, 221 patients with ...

    • A role for regulatory T cells in renal acute kidney injury 

      Monteiro, Rebecca M. M. [UNIFESP]; Camara, Niels O. S. [UNIFESP]; Rodrigues, Mauricio M. [UNIFESP]; Tzelepis, Fanny [UNIFESP]; Damiao, Marcio J. [UNIFESP]; Cenedeze, Marcos A. [UNIFESP]; Teixeira, Vicente de Paula A.; Reis, Marlene A. dos; Pacheco-Silva, Alvaro [UNIFESP] (Elsevier B.V., 2009-05-01)
      Ischemia reperfusion injury (IRI) is a potential contributor for the development of chronic allograft nephropathy. T cells are important mediators of injury, even in the absence of alloantigens. We performed a depletion ...

    • Transplantation With Kidneys Retrieved From Deceased Donors With Acute Renal Failure 

      Klein, Rodrigo [UNIFESP]; Galante, Nelson Zocoler [UNIFESP]; Sandes-Freitas, Taina Veras de [UNIFESP]; Franco, Marcello Fabiano de [UNIFESP]; Tedesco-Silva, Helio [UNIFESP]; Medina-Pestana, Jose Osmar [UNIFESP] (Lippincott Williams & Wilkins, 2013-02-27)
      Background. the discard rate of kidneys recovered from deceased donors with acute renal failure (ARF) is higher compared with those without ARF mainly due to the uncertainty regarding short-term and long-term outcomes.Methods. ...