Now showing items 1-10 of 10

    • Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor 

      Pinheiro, Nathalia Montouro [UNIFESP]; Banzato, Rosana; Tibério, Iolanda de Fátima Lopes Calvo; Prado, Marco Antônio Máximo; Prado, Vania Ferreira; Hamouda, Ayman; Prado, Carla Máximo [UNIFESP] (Nicola Scichilone, 2021-07)
      Abstract: (1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a sudden onset and intense inflammation. This study ...

    • Aspectos histomorfológicos e respiratórios em modelo de lesão pulmonar aguda por sepse em ratos tratados com pentoxifilina 

      Oliveira, Wagner Rogerio Souza de [UNIFESP]; Cavassani, Sâmia Santos [UNIFESP]; Maganhin, Carla Cristina [UNIFESP]; Carbonel, Adriana Aparecida Ferraz [UNIFESP]; Simões, Manuel de Jesus [UNIFESP]; Simões, Ricardo Santos [UNIFESP]; Junqueira, Virginia Berlanga Campos [UNIFESP]; Oliveira-Júnior, Itamar Souza [UNIFESP] (Associação Médica Brasileira, 2009-01-01)
      OBJECTIVE: Respiratory repercussion on acute lung injury in a model of induced sepsis intraperitoneally. METHODS: Fifteen animals taken at random were submitted to adult male Wistar rats. The rats were randomly divided ...

    • Bradykinin inducible receptor is essential to lipopolysaccharide-induced acute lung injury in mice 

      Campanholle, Gabriela; Landgraf, Richardt G. [UNIFESP]; Borducchi, Erica; Semedo, Patricia [UNIFESP]; Wang, Pamela H. M. [UNIFESP]; Amano, Mariane T.; Russo, Momtchilo; Pacheco-Silva, Alvaro [UNIFESP]; Jancar, Sonia; Camara, Niels O. S. [UNIFESP] (Elsevier B.V., 2010-05-25)
      Lipopolysaccharides from gram-negative bacteria are amongst the most common causative agents of acute lung injury, which is characterized by an inflammatory response, with cellular infiltration and the release of ...

    • Characterization of an animal model of severe sepsis associated with respiratory dysfunction 

      Azevedo, Luciano Cesar Pontes [UNIFESP]; Park, Marcelo; Noritomi, Danilo Teixeira; Maciel, Alexandre Toledo; Brunialti, Milena Karina Coló [UNIFESP]; Salomão, Reinaldo [UNIFESP] (Faculdade de Medicina / USP, 2007-01-01)
      PURPOSE: Pathophysiological studies in humans regarding sepsis are difficult to perform due to ethical and methodological concerns. In this context, animal models of sepsis can be useful to better understand this condition ...

    • Efeito do tratamento com sakuranetina isolada de baccharis retusa m modelo murino de inflamação pulmonar aguda induzida por instilação de LPS 

      Mernak, Marcia Isabel Bittencourt [UNIFESP] (Universidade Federal de São Paulo, 2014-02-09)
      Acute Respiratory Distress Syndrome (ARDS) is characterized by an intense inflammatory response, due to a pro-inflammatory and oxidant pathway activation, which induces early lung injury, followed by pulmonary remodeling. ...

    • Efeitos na função pulmonar após utilização de surfactante pulmonar exógeno na síndrome do desconforto respiratório agudo na criança 

      Carvalho, Werther Brunow de [UNIFESP]; Mângia, C.m.f. [UNIFESP] (Associação Médica Brasileira, 1997-06-01)
      The Acute Respiratory Distress Syndrome (ARDS) is a pulmonary lesion of multifactorial cause in which the surfactant system is altered owing to inactivation and impairment of composition and metabolism. The use of exogenous ...

    • Effect of pentoxifylline on lung inflammation and gas exchange in a sepsis-induced acute lung injury model 

      Oliveira-Júnior, Itamar Souza [UNIFESP]; Brunialti, Milena Karina Coló [UNIFESP]; Koh, Ivan Hong Jun [UNIFESP]; Junqueira, Virginia Berlanga Campos [UNIFESP]; Salomão, Reinaldo [UNIFESP] (Associação Brasileira de Divulgação Científica, 2006-11-01)
      Experimental models of sepsis-induced pulmonary alterations are important for the study of pathogenesis and for potential intervention therapies. The objective of the present study was to characterize lung dysfunction (low ...

    • Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung injury 

      Oliveira-Júnior, Itamar Souza [UNIFESP]; Maganhin, Carla Cristina [UNIFESP]; Carbonel, Adriana Aparecida Ferraz [UNIFESP]; Monteiro, Cristina Maria Rodrigues [UNIFESP]; Cavassani, Sâmia Santos [UNIFESP]; Oliveira-filho, Ricardo Martins [UNIFESP] (Faculdade de Medicina / USP, 2008-01-01)
      OBJECTIVE: To evaluate the effects of pentoxifylline on hydrochloric acid-induced lung lesions in rats subjected to mechanical ventilation. METHODS: Twenty male, adult Wistar-EPM-1 rats were anesthetized and randomly grouped ...

    • Pentoxifylline decreases tumor necrosis factor and interleukin-1 during high tidal volume 

      Oliveira-Júnior, Itamar Souza [UNIFESP]; Pinheiro, Bruno do Valle [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Salomão, Reinaldo [UNIFESP]; Zollner, Ricardo de Lima; Beppu, Osvaldo Shigueomi [UNIFESP] (Associação Brasileira de Divulgação Científica, 2003-10-01)
      Tumor necrosis factor-alpha (TNF-alpha) is one of the most important proinflammatory cytokines which plays a central role in host defense and in the acute inflammatory response related to tissue injury. The major source ...

    • Temporal evolution of acute respiratory distress syndrome definitions 

      Fioretto, José Roberto; Carvalho, Werther Brunow de [UNIFESP] (Soc Brasil Pediatria, 2013-11-01)
      Objective: to review the evolution of acute respiratory distress syndrome (ARDS) definitions and present the current definition for the syndrome.Data source: a literature review and selection of the most relevant articles ...