Now showing items 1-20 of 31

    • Abordagens inovadoras para o desenvolvimento de vacinas 

      Carrieri, Carolina Roberto [UNIFESP] (Universidade Federal de São Paulo, 2021-01-29)
      O sistema imunológico é capaz de eliminar corpos estranhos, como patógenos, para manter a homeostasia do corpo. Contudo, alguns desses patógenos são capazes de escapar dos mecanismos das respostas imunológicas. Por isso, ...

    • Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection 

      Torrecilhas, Ana Claudia [UNIFESP]; Xander, Patricia [UNIFESP]; Ferreira, Karen Spadari [UNIFESP]; Batista, Wagner Luiz [UNIFESP] (Bentham Science Publ Ltd, 2018)
      The neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of ...

    • Anticorpos monoclonais 

      Conceição, Ana Beatriz Alves da [UNIFESP] (Universidade Federal de São Paulo, 2021-02-05)
      Anticorpos monoclonais (mAbs) são moléculas de imunoglobulinas idênticas produzidas para um antígeno específico. Anticorpos são estruturalmente compostos por 2 cadeias leves e 2 cadeias pesadas que contém o sítio de ligação ...

    • Anticorpos monoclonais contra proteina de 75kDa da superficie de Paracoccidioides brasiliensis inibem o crescimento e diminuem a doenca experimental pelo fungo 

      Xander, Patricia [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2007)
      Paracoccidioides brasiliensis e fungo termo-dimorfico responsavel pela paracoccidioidomicose (PCM), micose granulomatosa sistemica prevalente na America Latina. O fungo libera muitos antigenos, os quais podem encontrar-se ...

    • Avaliação de peptídeos sintéticos selecionados por phage display para o sorodiagnóstico da Paracoccidioidomicose 

      Portes, Leticia da Silva [UNIFESP] (Universidade Federal de São Paulo, 2017-06-29)
      Paraccocidioidomycosis (PCM) is a systemic granulomatous disease caused by the thermo-dimorphic fungus from complex Paraccocidioides. The disease diagnosis uses both direct detection of the fungus in biological samples and ...

    • Avaliação do efeito de vesículas extracelulares liberadas por Leishmania (Leishmania) amazonensis na imunização de camundongos BALB/c 

      Dupin, Talita Vieira [UNIFESP] (Universidade Federal de São Paulo, 2021-08-26)
      Leishmanioses são um grupo de doenças causadas pelo protozoário do gênero Leishmania, ordem Kinetoplastida e da família Trypanosomatidae. A doença é endêmica em 97 países, sendo que 18 destes estão no continente Americano, ...

    • Avaliação dos efeitos de vesículas extracelulares produzidas por L. (L.) Amazonensis sobre células B-1 e macrófagos Murinos 

      Barbosa, Fernanda Marins Costa [UNIFESP] (Universidade Federal de São Paulo, 2017-06-27)
      Leishmaniasis is a group of diseases caused by protozoa belonging to the genus Leishmania. In mammalian hosts, the parasite is able to infect and proliferate within various types of cells such as tissue macrophages and B-1 ...

    • The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes 

      Perez, Elizabeth Cristina; Xander, Patricia [UNIFESP]; Lucatelli Laurindo, Maria Fernanda [UNIFESP]; Novaes e Brito, Ronni Romulo; Vivanco, Bruno Camolese [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Mariano, Mario [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Keller, Alexandre Castro [UNIFESP] (Public Library Science, 2017)
      B-1 lymphocytes are known to increase the metastatic potential of B16F10 melanoma cells via the extracellular signal-regulated kinase (ERK) pathway. Since IL-10 is associated with B-1 cells performance, we hypothesized ...

    • B-1 cells facilitate Paracoccidioides brasiliensis infection in mice via IL-10 secretion 

      Popi, Ana Flavia [UNIFESP]; Godoy, Luiz Claudio [UNIFESP]; Xander, Patricia [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Elsevier B.V., 2008-06-01)
      Protective immunity in paracoccidioidomycosis is mainly mediated by cellular immunity. the role of B cells in this disease, in particular B-1 cells, is poorly understood. the aim of this study was to characterize the ...

    • B-1 cells promote immunosurveillance against murine melanoma in host absence of CCR5: New perspective in autologous vaccination therapy 

      Vivanco, Bruno C. [UNIFESP]; Viana, Jacqueline D. [UNIFESP]; Perez, Elisabeth C.; Konno, Fabiana T. C.; Guereschi, Marcia G. [UNIFESP]; Xander, Patricia [UNIFESP]; Keller, Alexandre C. [UNIFESP]; Lopes, Jose D. [UNIFESP] (Elsevier B.V., 2014-11-01)
      Autologous vaccination with tumor-primed dendritic cells increases immune response against tumor, which seems to be improved in host absence of CCR5. Because B-1 lymphocytes modulate the activity of different immune cells, ...

    • Caracterização morfológica e funcional de vesículas extracelulares liberadas por células B-1 infectadas por Leishmania (Leishmania) Amazonensis 

      Toledo, Mayte dos Santos [UNIFESP] (Universidade Federal de São Paulo, 2018-03-26)
      Leishmaniasis is a group of diseases caused by protozoa belonging to the genus Leishmania. The immune response to leishmaniasis is complex and the outcome of the infection depends on several factors, such as genetic ...

    • A cell surface 230 kDa protein from murine melanoma involved with tumor malignancy 

      Mendes, Priscila Fraga Penteado [UNIFESP]; Xander, Patricia [UNIFESP]; Brito, Ronni Romulo Novaes e [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Elsevier B.V., 2008-04-18)
      Because melanoma incidence has increased at a dramatic rate, it is relevant to identify novel melanoma antigens for diagnosis and develop monoclonal antibodies recognizing such molecules. Some monoclonal antibodies (mAbs), ...

    • Cloning, characterization and expression of a calnexin homologue from the pathogenic fungus Paracoccidioides brasiliensis 

      Feitosa, Luciano dos Santos [UNIFESP]; Maria de Almeida Soares, Celia; Santos, Marcia Regina Machado [UNIFESP]; Melo Bailao, Alexandre; Xander, Patricia [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Daniel Lopes, Jose [UNIFESP] (Wiley-Blackwell, 2007-02-01)
      We report the cloning of a Paracoccidioides brasiliensis cDNA, here named PbCnx, encoding the homologue of the endoplasmic reticulum molecular chaperone calnexin. Calnexin specifically recognizes monoglucosylated glycoproteins ...

    • Crosstalk between B16 melanoma cells and B-1 lymphocytes induces global changes in tumor cell gene expression 

      Xander, Patricia [UNIFESP]; Novaes e Brito, Ronni Romulo; Perez, Elizabeth Cristina; Pozzibon, Jaqueline Maciel [UNIFESP]; Souza, Camila Ferreira de [UNIFESP]; Pellegrino, Renata [UNIFESP]; Bernardo, Viviane [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Mariano, Mario [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Elsevier B.V., 2013-10-01)
      The analysis of gene expression patterns in cancers has improved the understanding of the mechanisms underlying the process of metastatic progression. However, the acquisition of invasive behavior in melanoma is poorly ...

    • Epigenetic reprogramming as a key contributor to melanocyte malignant transformation 

      Molognoni, Fernanda [UNIFESP]; Cruz, Adriana Taveira da [UNIFESP]; Meliso, Fabiana Marcelino [UNIFESP]; Morais, Alice Santana [UNIFESP]; Souza, Camila Ferreira [UNIFESP]; Xander, Patricia [UNIFESP]; Bischof, Jared M.; Costa, Fabricio F.; Soares, Marcelo B.; Liang, Gangning; Jones, Peter A.; Jasiulionis, Miriam Galvonas [UNIFESP] (Landes Bioscience, 2011-04-01)
      Melanoma progression requires deregulation of gene expression by currently uncharacterized epigenetic mechanisms. A mouse model based on changes in cell microenvironment was developed by our group to study melanocyte ...

    • EVALUATION OF EXPERIMENTAL INFECTION WITH L. (L.) AMAZONENSIS IN X-LINKED IMMUNODEFICIENT MICE 

      Gonzaga, Wagner Francisco Kennerly Marcondes [UNIFESP]; Geraldo, Mariana Marques [UNIFESP]; Vivanco, Bruno Camolese [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Mariano, Mario [UNIFESP]; Batista, Wagner Luiz [UNIFESP]; Xander, Patricia [UNIFESP] (Amer Soc Parasitologists, 2017)
      B-1 cells are a subtype of B cells with peculiar characteristics. These cells are distinct from B-2 lymphocytes in their morphology, ontogeny, tissue distribution, and phenotypic functional features. B-1 cells can participate ...

    • Exploring Potential Virulence Regulators in Paracoccidioides brasiliensis Isolates of Varying Virulence through Quantitative Proteomics 

      Castilho, Daniele G. [UNIFESP]; Chaves, Alison F. A. [UNIFESP]; Xander, Patricia [UNIFESP]; Zelanis, Andre [UNIFESP]; Kitano, Eduardo S.; Serrano, Solange M. T.; Tashima, Alexandre K. [UNIFESP]; Batista, Wagner L. [UNIFESP] (Amer Chemical Soc, 2014-10-01)
      Few virulence factors have been identified for Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. in this study, we quantitatively evaluated the protein composition of P. brasiliensis in the yeast phase ...

    • Gene Expression in B-1 Cells from Lupus-Prone Mice 

      Novaes e Brito, Ronni Romulo [UNIFESP]; Xander, Patricia [UNIFESP]; Perez, Elizabeth C. [UNIFESP]; Maricato, Juliana Terzi [UNIFESP]; Laurindo, Maria Fl. [UNIFESP]; De Lorenzo, Beatriz H. P. [UNIFESP]; Pellegrino, Renata [UNIFESP]; Bernardo, Viviane [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Informa Healthcare, 2014-01-01)
      New Zealand Black X New Zealand White F1 [(NZB/NZW) F1] mice develop an autoimmune condition with similarities to human systemic lupus erythematosus (SLE). in this study, we demonstrate that B-1 cells, which have previously ...

    • Granuloma formation in vitro requires B-1 cells and is modulated by Paracoccidioides brasiliensis gp43 antigen 

      Vigna, A. F.; Almeida, SR; Xander, Patricia [UNIFESP]; Freymuller, E.; Mariano, M.; Lopes, J. D. (Elsevier B.V., 2006-03-01)
      The mechanisms that determine granuloma formation and the significance of this type of inflammatory response in the pathogenesis of fungal diseases such as paracoccidioidomycosis are far from fully understood. We developed ...

    • Guia de boas práticas acadêmicas 

      Slemian, Andréa [UNIFESP]; Comparato, Bruno Konder [UNIFESP]; Antunes, Hanna Karen Moreira [UNIFESP]; Silva, Lucía [UNIFESP]; Leite, Nildes Raimunda Pitombo [UNIFESP]; Xander, Patricia [UNIFESP]; Mattos, Paulo Eduardo Orlandi [UNIFESP]; Malaspina, Thaciana [UNIFESP]; Santos, Vagner Rogério dos [UNIFESP] (UNIFESP, 2021-10)
      Todo saber científico é fruto de uma reflexão coletiva. Mesmo uma nova invenção reproduz ou coloca à prova conhecimentos acumulados ou partilhados pela comunidade científica. Reconhecer esse saber acumulado é um primeiro ...