Now showing items 1-20 of 930

    • 24 bp duplication of CHIT1 gene and determinants of human chitotriosidase activity among participants of EPISONO, a population-based cross-sectional study, São Paulo, Brazil 

      Tamanaha, Priscila [UNIFESP]; D'Almeida, Vania [UNIFESP]; Calegare, Bruno F. A. [UNIFESP]; Tomita, Luciana Yuki [UNIFESP]; Bittencourt, Lia Rita A. [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2013-08-01)
      Objectives: We investigated whether plasma chitotriosidase activity is related to Obstructive Sleep Apnea (OSA) conditions and is correlated with biochemical variables present in the EPISONO database. This is the first ...
    • Absence of oxidative stress following paradoxical sleep deprivation in rats 

      DAlmeida, V; Hipolide, D. C.; Azzalis, L. A.; Lobo, L. L.; Junqueira, VBC; Tufik, Sergio [UNIFESP] (Elsevier B.V., 1997-10-10)
      Paradoxical sleep deprivation was performed on rats using platform technique to investigate the oxidative process associated with it. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total ...
    • Achados clínicos e polissonográficos em pacientes com obesidade classe III 

      Tangerina, Rodrigo De Paiva; Martinho, Fernanda Louise; Togeiro, Sonia Maria [UNIFESP]; Gregório, Luiz Carlos [UNIFESP]; Tufik, Sergio [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP] (ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2008-08-01)
      The Obstructive Sleep Apnea/Hipopnea Syndrome (OSAHS) is closely related to obesity; a linear relation, however, has not been established, particularly in morbid obesity patients. AIM: To evaluate clinical and polysomnographic ...
    • Acoustic arousal responses in children with obstructive sleep apnea 

      Moreira, G. A.; Tufik, Sergio [UNIFESP]; Nery, L. E.; Lutz, J.; Verfaille, K.; Luan, X. Q.; Marcus, C. L. (Wiley-Blackwell, 2005-10-01)
      Our objectives were to study the arousal responses to nonrespiratory (acoustic) stimuli in children with obstructive sleep apnea syndrome (OSAS). the acoustic arousal response was studied in children with OSAS due to ...
    • Actigraphy-Based Sleep Parameters During the Reinstatement of Methamphetamine Self-Administration in Rhesus Monkeys 

      Berro, Laís Fernanda [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Tufik, Sergio [UNIFESP]; Howell, Leonard L. (Amer Psychological Assoc, 2016)
      The objective of this study was to investigate nighttime activity of nonhuman primates during extinction and cue-and drug-primed reinstatement of methamphetamine self-administration. Adult rhesus monkeys (Macaca mulatta
    • Activation of C-fiber nociceptors by low-power diode laser 

      Azevedo, Eduardo [UNIFESP]; Silva, Andressa [UNIFESP]; Martins, Raquel [UNIFESP]; Andersen, Monica L. [UNIFESP]; Tufik, Sergio [UNIFESP]; Manzano, Gilberto M. [UNIFESP] (Assoc Arquivos Neuro- Psiquiatria, 2016)
      Objective: The evaluation of selective activation of C-fibers to record evoked potentials using the association of low-power diode laser (810 nm), tiny-area stimulation and skin-blackening. Method: Laser-evoked potentials ...
    • Acupuncture improves sleep in postmenopause in a randomized, double-blind, placebo-controlled study 

      Hachul, H. [UNIFESP]; Garcia, T. K. P. [UNIFESP]; Maciel, A. L. [UNIFESP]; Yagihara, F. [UNIFESP]; Tufik, Sergio [UNIFESP]; Bittencourt, L. [UNIFESP] (Informa Healthcare, 2013-02-01)
      Background Insomnia increases in frequency as women approach and pass through menopause. Studies have not shown acupuncture efficacy for insomnia in postmenopausal women.Objectives the aim of this study was to evaluate the ...
    • Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers 

      Pompeia, Sabine [UNIFESP]; Grego, Bruno H. C. [UNIFESP]; Pradella-Hallinan, Marcia [UNIFESP]; Hachul, Helena [UNIFESP]; Tufik, Sergio [UNIFESP]; D'Almeida, Vania [UNIFESP] (Elsevier B.V., 2009-08-31)
      Purpose: High cortisol plasma concentrations have been shown to be associated with increases in homocysteine levels. Here we studied whether decreases in cortisol concentration, induced by an acute oral dose of a benzodiazepine, ...
    • Acute cocaine effects in paradoxical sleep deprived male rats 

      Andersen, Monica Levy [UNIFESP]; Perry, Juliana Cini [UNIFESP]; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2005-02-01)
      Cocaine is a psychomotor drug known to cause behavioural alterations. This study was conducted to characterize behavioural response to acute cocaine injection (7 mg/kg, ip) in paradoxical sleep deprived (PSD) male rats ...
    • Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain 

      Dalio, Fernanda Montiel [UNIFESP]; Visniauskas, Bruna [UNIFESP]; Bicocchi, Eliane S.; Perry, Juliana Cini [UNIFESP]; Freua, Rodrigo [UNIFESP]; Gesteira, Tarsis Ferreira [UNIFESP]; Nader, Helena Bonciani [UNIFESP]; Machado, Mauricio Ferreira Marcondes [UNIFESP]; Tufik, Sergio [UNIFESP]; Ferro, Emer Suavinho [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Toledo, Claudio A. B.; Chagas, Jair Ribeiro [UNIFESP]; Oliveira, Vitor [UNIFESP] (Elsevier B.V., 2012-03-23)
      Many studies indicate that thimet oligopeptidase (EC3.4.24.15; TOP) can be implicated in the metabolism of bioactive peptides, including dynorphin 1-8, alpha-neoendorphin, beta-neoendorphin and GnRH. Furthermore, the higher ...
    • Acute cognitive effects of donepezil in young, healthy volunteers 

      Zaninotto, Ana L. C. [UNIFESP]; Bueno, Orlando F. A. [UNIFESP]; Pradella-Hallinan, Marcia [UNIFESP]; Tufik, Sergio [UNIFESP]; Rusted, Jenny; Stough, Con; Pompeia, Sabine [UNIFESP] (Wiley-Blackwell, 2009-08-01)
      Objective the acute nootropic potential of donepezil in young healthy volunteers has not been adequately investigated mainly because in previous studies: (1) effects were assessed before peak-plasma concentration (Tmax) ...
    • Acute effect of nasal continuous positive air pressure on the ventilatory control of patients with obstructive sleep apnea 

      Moura, SMT; Bittencourt, L. R.; Bagnato, Maurício da Cunha [UNIFESP]; Lucas, SR; Tufik, Sergio [UNIFESP]; Nery, L. E. (Karger, 2001-05-01)
      Background: Sleep fragmentation can decrease the awake ventilatory control. Since patients with obstructive sleep apnea (OSA) patients exhibit sleep fragmentation linked to respiratory events, their ventilatory control ...
    • Acute effects of donepezil in healthy young adults underline the fractionation of executive functioning 

      Ginani, G. E. [UNIFESP]; Tufik, Sergio [UNIFESP]; Bueno, O. F. A. [UNIFESP]; Pradella-Hallinan, M. [UNIFESP]; Rusted, J.; Pompeia, S. [UNIFESP] (Sage Publications Ltd, 2011-11-01)
      The cholinergic system is involved in the modulation of both bottom-up and top-down attentional control. Top-down attention engages multiple executive control processes, but few studies have investigated whether all or ...
    • Acute neurophysiological effects of the hypnotic zolpidem in healthy volunteers 

      Lucchesi, L. M.; Braga, NID; Manzano, G. M.; Pompeia, S.; Tufik, Sergio [UNIFESP] (Elsevier B.V., 2005-05-01)
      Introduction: the imidazopyridine zolpidem is a hypnotic drug with relative selectivity for the benzodiazepine (BZP) type 1 receptor subtypes displaying a different biochemical structure to that of BZPs. Little is known ...
    • Acute physical exercise under hypoxia improves sleep, mood and reaction time 

      Lemos, Valdir de Aquino [UNIFESP]; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Antunes, Hanna Karen Moreira [UNIFESP]; Lira, Fabio Santos de; Bittar, Irene Guarido Luz [UNIFESP]; Caris, Aline Venticinque [UNIFESP]; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de (Pergamon-Elsevier Science Ltd, 2016)
      This study aimed to assess the effect of two sessions of acute physical exercise at 50% VO2peak performed under hypoxia (equivalent to an altitude of 4500 in for 28 h) on sleep, mood and reaction time. Forty healthy men ...
    • Acute sleep restriction increases energy expenditure in obese men 

      Zimberg, Ioná Zalcman [UNIFESP]; Del Re, Mariana Pantaleão [UNIFESP]; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de [UNIFESP] (Karger, 2017)
    • Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats 

      Souza, Femanda G. de; Rodrigues, Mayra D. B.; Tufik, Sergio [UNIFESP]; Nobrega, Jose N.; D'Almeida, Vania (Elsevier B.V., 2006-10-01)
      Homocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including ...
    • Acute systemic blockade of D2 receptors does not accelerate the extinction of cocaine-associated place preference 

      Yim Júnior, Alberto [UNIFESP]; Andersen, M. L. [UNIFESP]; Soeiro, A. C. [UNIFESP]; Tufik, Sergio [UNIFESP]; Oliveira, Maria Gabriela Menezes de [UNIFESP] (Elsevier B.V., 2009-12-04)
      Facilitation of extinction can be used as a therapeutic tool in treatment of both post-traumatic stress disorder and drug addiction. the present study examined whether the blockade of D2 receptors before each extinction ...
    • Acute total sleep deprivation potentiates amphetamine-induced locomotor-stimulant effects and behavioral sensitization in mice 

      Saito, Luis P. [UNIFESP]; Fukushiro, Daniela F. [UNIFESP]; Hollais, Andre W. [UNIFESP]; Mari-Kawamoto, Elisa [UNIFESP]; Costa, Jacqueline M. [UNIFESP]; Berro, Lais F. [UNIFESP]; Aramini, Tatiana C. F. [UNIFESP]; Wuo-Silva, Raphael [UNIFESP]; Andersen, Monica L. [UNIFESP]; Tufik, Sergio [UNIFESP]; Frussa-Filho, Roberto [UNIFESP] (Elsevier B.V., 2014-02-01)
      It has been demonstrated that a prolonged period (48 h) of paradoxical sleep deprivation (PSD) potentiates amphetamine (AMP)-induced behavioral sensitization, an animal model of addiction-related neuroadaptations. in the ...
    • Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice 

      Berro, Laís Fernanda [UNIFESP]; Santos, Renan [UNIFESP]; Hollais, André Willian [UNIFESP]; Wuo-Silva, Raphael [UNIFESP]; Fukushiro, Daniela Fukue [UNIFESP]; Mári-Kawamoto, Elisa [UNIFESP]; Costa, Jacqueline Menezes [UNIFESP]; Trombin, Thaís Fernanda [UNIFESP]; Patti, Camila de Lima [UNIFESP]; Grapiglia, Stephanie Berzin [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Frussa Filho, Roberto [UNIFESP] (Elsevier B.V., 2014-09-05)
      Sleep deprivation is common place in modern society. Nowadays, people tend to self-impose less sleep in order to achieve professional or social goals. in the social context, late-night parties are frequently associated ...