Now showing items 1-9 of 9

    • Differences in neonatal exposure to estradiol or testosterone on ovarian function and hormonal levels 

      Marcondes, Rodrigo R.; Carvalho, Katia C.; Duarte, Daniele C.; Garcia, Natalia; Amaral, Vinicius C.; Simoes, Manuel J. [UNIFESP]; Lo Turco, Edson G. [UNIFESP]; Soares, Jose M.; Baracat, Edmund C.; Maciel, Gustavo A. R. (Elsevier B.V., 2015-02-01)
      Exposure to an excess of androgen or estrogen can induce changes in reproductive function in adult animals that resemble polycystic ovary syndrome in humans. However, considerable differences exist among several types of ...
    • Effects of hexestrol on mouse ovarian morphology and ovulation 

      Oliveira, Joaquim Moraes de [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Mora, Oswaldo Alves [UNIFESP]; Simoes, Ricardo Santos [UNIFESP]; Oliveira-Filho, Ricardo M. [UNIFESP]; Oliveira, Patricia B. [UNIFESP]; Baracat, Edmund C. [UNIFESP]; Soares, Jose Maria [UNIFESP] (Elsevier B.V., 2008-06-20)
      Objective: To analyze histological aspects of ovaries as well as the ovulation of adult mice treated with the anabolic agent hexestrol.Methods: Thirty adult mice were divided into three groups of 10 animals each: (GI) the ...
    • Effects of lidocaine with epinephrine or with buffer on wound healing in rat skin 

      Rodrigues, Felipe V. [UNIFESP]; Hochman, Bernardo [UNIFESP]; Wood, Viviane T. [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Juliano, Yara [UNIFESP]; Ferreira, Lydia M. [UNIFESP] (Wiley-Blackwell, 2011-03-01)
      Lidocaine blocks nociceptive fibers, preventing initial wound signaling and mast cell degranulation. It is hypothesized that epinephrine and buffer affect the wound healing by potentiating lidocaine blockage. This double-blind, ...
    • The effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacy 

      Moraes, Andrea B. [UNIFESP]; Haidar, Mauro Abi [UNIFESP]; Soares Junior, Jose Maria [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Baracat, Edmund C.; Patriarca, Marisa T. [UNIFESP] (Elsevier B.V., 2009-10-01)
      Objective: the aim of this study was to evaluate the effects of estrogen and isoflavones on postmenopausal skin morphological parameters.Study design: A randomized, double-blind, estrogen-controlled trial was performed on ...
    • Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats 

      Ptilovanciv, Ellen O. N. [UNIFESP]; Fernandes, Gabryelle S. [UNIFESP]; Teixeira, Luciana C. [UNIFESP]; Reis, Luciana A. [UNIFESP]; Pessoa, Edson A. [UNIFESP]; Convento, Marcia B. [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Albertoni, Guilherme A. [UNIFESP]; Schor, Nestor [UNIFESP]; Borges, Fernanda T. [UNIFESP] (Biomed Central Ltd, 2013-01-16)
      One important concern in the treatment of diabetes is the maintenance of glycemic levels and the prevention of diabetic nephropathy. Inducible heme oxygenase 1 (HO-1) is a rate-limiting enzyme thought to have antioxidant ...
    • Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats 

      Anzai, Alvaro; Marcondes, Rodrigo R.; Goncalves, Thiago H.; Carvalho, Katia C.; Simoes, Manuel J. [UNIFESP]; Garcia, Natalia; Soares, Jose M., Jr.; Padmanabhan, Vasantha; Baracat, Edmund C.; da Silva, Ismael D. C. G. [UNIFESP]; Maciel, Gustavo A. R. (Nature Publishing Group, 2017)
      Polycystic ovary syndrome (PCOS) is frequently associated with non-alcoholic fatty liver disease (NAFLD), but the mechanisms involved in the development of NAFLD in PCOS are not well known. We investigated histological ...
    • Influence of estrogen replacement and aging on the expression of nerve growth factor in the urethra of female rats 

      Zucchi, Eliana V. M. [UNIFESP]; Jarmy-Di Bella, Zsuzsanna I. K. [UNIFESP]; Castro, Rodrigo A. [UNIFESP]; Takano, Claudia C. [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Girao, Manoel J. B. C. [UNIFESP]; Sartori, Marair G. F. [UNIFESP] (Wiley-Blackwell, 2012-06-01)
      Objective To evaluate the expression of nerve growth factor (NGF) in the urethra of adult female rats in different hormonal status using immunohistochemical assay. Methods Forty-eight rats (Rattus norvegicus albinus, ...
    • Melatonin influences on steroidogenic gene expression in the ovary of pinealectomized rats 

      Maganhin, Carla C. [UNIFESP]; Simoes, Ricardo S.; Fuchs, Luiz F. P.; Sasso, Gisela R. S. [UNIFESP]; Simoes, Manuel J. [UNIFESP]; Baracat, Edmund C.; Soares, Jose M. (Elsevier B.V., 2014-07-01)
      Objective: To analyze the expression of genes related to steroidogenesis in the ovary of pinealectomized rats.Design: Experimental research.Setting: University research laboratory.Animal(s): Thirty female adult rats. ...
    • Morphofunctional alterations of the nonpregnant murine uterus in response to intense and exhaustive exercise are not related to oxidative stress 

      Costa, Alessandra E. A. [UNIFESP]; Silva, Joelmir L. V.; Simoes, Manuel J. [UNIFESP]; Nouailhetas, Viviane L. A. [UNIFESP] (Amer Physiological Soc, 2014-03-01)
      Exercise is a common and noninvasive way to improve human health. in contrast, intense exercise causes damage in various tissues and is usually associated with metabolic changes in organs and tissues. Even though intense ...