Now showing items 1-20 of 45

    • alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model 

      Matsuo, Alisson Leonardo [UNIFESP]; Figueiredo, Carlos Rogerio [UNIFESP]; Arruda, Denise Costa [UNIFESP]; Pereira, Felipe Valença [UNIFESP]; Scutti, Jorge Augusto Borin [UNIFESP]; Massaoka, Mariana Hiromi [UNIFESP]; Travassos, Luiz Rodolpho [UNIFESP]; Sartorelli, Patricia [UNIFESP]; Lago, Joao Henrique Ghilardi [UNIFESP] (Elsevier B.V., 2011-07-29)
      Malignant melanoma is one the most aggressive types of cancer and its incidence has gradually increased in the last years, accounting for about 75% of skin cancer deaths. This poor prognosis results from the tumor resistance ...
    • Amino Acid Permeases and Virulence in Cryptococcus neoformans 

      Martho, Kevin Felipe Cruz [UNIFESP]; Melo, Amanda Teixeira de [UNIFESP]; Fernandes Takahashi, Juliana Possato; Guerra, Juliana Mariotti; da Silva Santos, Dayane Cristina; Purisco, Sonia Ueda; Carvalho Melhem, Marcia de Souza; Fazioli, Raquel dos Anjos; Phanord, Clerlune [UNIFESP]; Sartorelli, Patricia [UNIFESP]; Vallim, Marcelo Afonso [UNIFESP]; Pascon, Renata Castiglioni [UNIFESP] (Public Library Science, 2016)
      Fungal opportunistic pathogens colonize various environments, from plants and wood to human and animal tissue. Regarding human pathogens, one great challenge during contrasting niche occupation is the adaptation to different ...
    • Análise química e biológica dos constituintes fixos e voláteis de Casearia sylvestris sw. (Salicaceae) 

      Bou, Diego Dinis [UNIFESP] (Universidade Federal de São Paulo, 2013-10-05)
      The present work aimed at the isolation of the chemical constituents of C. sylvestris (Salicaceae), as well as evaluating the cytotoxic activity against tumor cell lines and assays for detection of anti-Leishmania activity ...
    • Anti-leishmanial and anti-trypanosomal potential of polygodial isolated from stem barks of Drimys brasiliensis Miers (Winteraceae) 

      Correa, Daniela S.; Tempone, Andre G.; Reimao, Juliana Q.; Taniwaki, Noemi N.; Romoff, Paulete; Favero, Oriana A.; Sartorelli, Patricia [UNIFESP]; Mecchi, Murilo C. [UNIFESP]; Lago, Joao Henrique G. [UNIFESP] (Springer, 2011-07-01)
      Parasitic protozoan diseases affect the poorest population in developing countries. Leishmaniasis and Chagas disease have been included among the most important threats for public health in Central and South American ...
    • Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae) 

      Morais, Thiago R.; Romoff, Paulete; Favero, Oriana A.; Reimao, Juliana Q.; Lourenco, Walkyria C.; Tempone, Andre G.; Hristov, Angelica D.; Di Santi, Silvia M.; Lago, Joao Henrique G. [UNIFESP]; Sartorelli, Patricia [UNIFESP]; Ferreira, Marcelo J. P. (Springer, 2012-01-01)
      Leishmaniasis, Chagas disease, and malaria affect the poorest population around the world, with an elevated mortality and morbidity. in addition, the therapeutic alternatives are usually toxic or ineffective drugs especially ...
    • Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) 

      Santos, Roberta Tancredi dos [UNIFESP]; Hiramoto, Liliane Lumi [UNIFESP]; Lago, Joao Henrique Ghilardi [UNIFESP]; Sartorelli, Patricia [UNIFESP]; Tempone, André Gustavo [UNIFESP]; Pinto, Erika Gracielle (Sociedade Brasileira de Química, 2012-01-01)
      MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as ...
    • Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella 

      Grecco, Simone dos Santos [UNIFESP]; Felix, Maria Julia Pereira [UNIFESP]; Lago, Joao Henrique Ghilardi [UNIFESP]; Pinto, Erika Gracielle; Tempone, André Gustavo; Romoff, Paulete; Ferreira, Marcelo José Pena; Sartorelli, Patricia [UNIFESP] (Natural Products Inc, 2014-02-01)
      Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin ...
    • Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae) 

      Santos, Augusto L. [UNIFESP]; Yamamoto, Eduardo S.; Passero, Luiz Felipe D.; Laurenti, Marcia D.; Martins, Ligia F.; Lima, Marta L.; Uemi, Miriam [UNIFESP]; Soares, Marisi G.; Lago, Joao Henrique G.; Tempone, Andre G.; Sartorelli, Patricia [UNIFESP] (Wiley-V C H Verlag Gmbh, 2017)
      Bioactivity-guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin (1), 1,6 '-di-O-beta-D-vanilloyl glucopyranoside (2) and vanillic acid (3). ...
    • Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L. 

      Dal Picolo, Camilla R. [UNIFESP]; Bezerra, Mariana P. [UNIFESP]; Gomes, Kaio S. [UNIFESP]; Passero, Luiz Felipe D.; Laurenti, Marcia D.; Martins, Euder Glendes A.; Sartorelli, Patricia [UNIFESP]; Lago, Joao Henrique G. [UNIFESP] (Elsevier B.V., 2014-09-01)
      Bioactivity-guided fractionation of EtOH extract from the leaves of Piper aduncum L. (Piperaceae) afforded a new dihydrochalcone, named adunchalcone. Its structure was elucidated on the basis of their spectroscopic data, ...
    • Antileishmanial and antitrypanosomal activity of bufadienolides isolated from the toad Rhinella jimi parotoid macrogland secretion 

      Tempone, Andre Gustavo [UNIFESP]; Pimenta, Daniel Carvalho; Lebrun, Ivo; Sartorelli, Patricia [UNIFESP]; Taniwaki, Noemi N.; Andrade, Heitor Franco de; Antoniazzi, Marta Maria; Jared, Carlos (Elsevier B.V., 2008-07-01)
      Amphibian skin secretions are considered a rich source of biologically active compounds and are known to be rich in peptides, bufadienolides and alkaloids. Bufadienolides are cardioactive steroids from animals and plants ...
    • Antiparasitic activity of biochanin A, an isolated isoflavone from fruits of Cassia fistula (Leguminosae) 

      Sartorelli, Patricia [UNIFESP]; Carvalho, Camila Salomone; Reimao, Juliana Quero; Pena Ferreira, Marcelo Jose; Tempone, Andre Gustavo (Springer, 2009-01-01)
      The fractionation through bioguided antileishmanial activity of the dichloromethane extract of Cassia fistula fruits (Leguminosae) led to the isolation of the active isoflavone biochanin A, identified by spectroscopic ...
    • Antiparasitic Activity of Natural and Semi-Synthetic Tirucallane Triterpenoids from Schinus terebinthifolius (Anacardiaceae): Structure/Activity Relationships 

      Morais, Thiago R. [UNIFESP]; Costa-Silva, Thais A. da; Tempone, Andre G.; Borborema, Samanta Etel T.; Scotti, Marcus T.; Sousa, Raquel Maria F. de; Araujo, Ana Carolina C.; Oliveira, Alberto de; Morais, Sergio Antonio L. de; Sartorelli, Patricia [UNIFESP]; Lago, Joao Henrique G. [UNIFESP] (Mdpi Ag, 2014-05-01)
      Leishmaniasis and Chagas are diseases caused by parasitic protozoans that affect the poorest population in the World, causing a high mortality and morbidity. As a result of highly toxic and long-term treatments, the discovery ...
    • Antitrypanosomal activity and evaluation of the mechanism of action of dehydrodieugenol isolated from Nectandra leucantha (Lauraceae) and its methylated derivative against Trypanosoma cruzi 

      Grecco, Simone S.; Costa-Silva, Thais A.; Jerz, Gerold; de Sousa, Fernanda S. [UNIFESP]; Alves Conserva, Geanne A. [UNIFESP]; Mesquita, Juliana T.; Galuppo, Mariana K.; Tempone, Andre G.; Neves, Bruno J.; Andrade, Carolina H.; Cunha, Rodrigo L. O. R.; Uemi, Miriam [UNIFESP]; Sartorelli, Patricia [UNIFESP]; Lago, Joao Henrique G. (Elsevier Gmbh, Urban & Fischer Verlag, 2017)
      Background: From a previous screening of Brazilian biodiversity for antiprotozoal activity, the hexane extract from leaves of Nectandra leucantha (Nees & Mart.) (Lauraceae) demonstrated activity against Trypanosoma cruzi. ...
    • Antitrypanosomal Activity of a Diterpene and Lignans Isolated from Aristolochia cymbifera 

      Sartorelli, Patricia [UNIFESP]; Carvalho, Camila Salomone [UNIFESP]; Reimao, Juliana Quero; Lorenzi, Harri; Tempone, Andre Gustavo (Georg Thieme Verlag Kg, 2010-09-01)
      Bioguided fractionation of extract from the leaves of Aristolochia cymbifera led to the isolation of the furofuran lignans fargesin, epieudesmin, and sesamin; the dibenzylbutyrolactone lignans hinokinin and kusunokinin; ...
    • Application of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxic Metabolites from Fruits of Schinus terebinthifolius Raddi (Anacardiaceae) 

      Morais, Thiago R. [UNIFESP]; Coutinho, Ana Paula R. [UNIFESP]; Camilo, Fernanda F. [UNIFESP]; Martins, Tereza S. [UNIFESP]; Sartorelli, Patricia [UNIFESP]; Massaoka, Mariana H. [UNIFESP]; Figueiredo, Carlos R. [UNIFESP]; Lago, Joao Henrique G. [UNIFESP] (Soc Brasileira Quimica, 2017)
      This work reports the application of an ionic liquid (1-butyl-3-methylimidazolium bromide, BMImBr) in the microwave assisted extraction (MAE) of metabolites from fruits of Schinus terebinthifolius. Dried fruits were ...
    • Brazilian flora extracts as source of novel antileishmanial and antifungal compounds 

      Tempone, André Gustavo; Sartorelli, Patricia [UNIFESP]; Teixeira, Denise; Prado, Frederico O; Calixto, Ivete Arl; Lorenzi, Harri; Melhem, Márcia Sc (Instituto Oswaldo Cruz, Ministério da Saúde, 2008-08-01)
      Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. ...
    • Busca de substâncias antitumorais e antiparasitárias de Casearia arbórea RICH (Salicaceae) 

      Santos, Augusto Leonardo dos [UNIFESP] (Universidade Federal de São Paulo, 2015-09-10)
      This presente work aimed the isolation of chemical constituintes accumulated on the leaves of Casearia arborea (Salicaceae) and evaluation of the cytotoxic activity, anti-proliferative ando anti-migratory against B16F10 ...
    • Casearin D inhibits ERK phosphorylation and induces downregulation of cyclin D1 in HepG2 cells 

      Ferreira-Silva, Guilherme Alvaro; Lages, Carla Carolina Lopes; Sartorelli, Patricia [UNIFESP]; Hasegawa, Flavia Rie [UNIFESP]; Soares, Marisi Gomes; Ionta, Marisa (Pergamon-Elsevier Science Ltd, 2017)
      Cancer is a public health problem which represents the second cause of death in the world. In this framework, it is necessary to identify novel compounds with antineoplastic potential. Plants are an important source for ...
    • Chemical and Biological Evaluation of Essential Oils from Two Species of Myrtaceae - Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel 

      Lago, Joao Henrique Ghilardi [UNIFESP]; Souza, Elisangela Dutra [UNIFESP]; Mariane, Bruna [UNIFESP]; Pascon, Renata [UNIFESP]; Vallim, Marcelo A. [UNIFESP]; Martins, Roberto Carlos C.; Baroli, Adriana A.; Carvalho, Bianca A.; Soares, Marisi G.; Santos, Roberta T. dos [UNIFESP]; Sartorelli, Patricia [UNIFESP] (Mdpi Ag, 2011-12-01)
      The chemical composition and antimicrobial activity of essential oils obtained from leaves of two Myrtaceae species-Eugenia uniflora L. and Plinia trunciflora (O. Berg) Kausel-were determined. Analysis by GC/MS as well as ...
    • Chemical Composition and Cytotoxicity Evaluation of Essential Oil from Leaves of Casearia Sylvestris, Its Main Compound alpha-Zingiberene and Derivatives 

      Bou, Diego Dinis [UNIFESP]; Lago, Joao Henrique Ghilardi [UNIFESP]; Figueiredo, Carlos Rogerio [UNIFESP]; Matsuo, Alisson Leonardo [UNIFESP]; Guadagnin, Rafael Carlos [UNIFESP]; Soares, Marisi Gomes; Sartorelli, Patricia [UNIFESP] (Mdpi Ag, 2013-08-01)
      Casearia sylvestris (Salicaceae), popularly known as guacatonga, is a plant widely used in folk medicine to treat various diseases, including cancer. the present work deals with the chemical composition as well as the ...