Now showing items 1-20 of 63

    • Adjuvant Effect of Killed Propionibacterium acnes on Mouse Peritoneal B-1 Lymphocytes and Their Early Phagocyte Differentiation 

      Mussalem, Juliana Sekeres [UNIFESP]; Squaiella, Carla Cristina [UNIFESP]; Teixeira, Daniela [UNIFESP]; Yendo, Tatiana Mina [UNIFESP]; Thies, Felipe Garutti [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Mariano, Mario [UNIFESP]; Longo-Maugeri, Ieda [UNIFESP] (Public Library Science, 2012-03-20)
      B-1 lymphocytes are the predominant cells in mouse peritoneal cavity. They express macrophage and lymphocyte markers and are divided into B-1a, B-1b and B-1c subtypes. the role of B-1 cells is not completely clear, but ...
    • Auto-anticorpos dirigidos à componentes da matriz extracelular em pacientes portadores de diferentes formas de periodontite 

      Gennaro, Luiz Antonio de [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2000)
      A doenca periodontal e uma enfermidade infecciosa de carater inflamatorio cronico que ocorre nos tecidos de protecao e sustentacao dente. Nas formas mais graves da doenca ocorrem extensas destruicoes desse tecidos com a ...
    • The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes 

      Perez, Elizabeth Cristina; Xander, Patricia [UNIFESP]; Lucatelli Laurindo, Maria Fernanda [UNIFESP]; Novaes e Brito, Ronni Romulo; Vivanco, Bruno Camolese [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Mariano, Mario [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Keller, Alexandre Castro [UNIFESP] (Public Library Science, 2017)
      B-1 lymphocytes are known to increase the metastatic potential of B16F10 melanoma cells via the extracellular signal-regulated kinase (ERK) pathway. Since IL-10 is associated with B-1 cells performance, we hypothesized ...
    • B-1 cell participation in T-cell-mediated alloimmune response 

      Nogueira-Martins, Mauro F. [UNIFESP]; Mariano, Mario [UNIFESP] (Elsevier B.V., 2010-04-01)
      B-1 and B cells are important producers of natural antibodies in mice and humans and, therefore, are considered as the first line of defense against pathogens. Because of that, their role in T-cell-mediated immune responses ...
    • B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection 

      Russo, Ricardo T.; Mariano, Mario [UNIFESP] (Elsevier B.V., 2010-12-01)
      B-1 cells were first described in the early 1980s and are distinct from conventional B lymphocytes in respect to phenotype, morphology, ontogeny, tissular distribution and function. Although many years have been past since ...
    • B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties 

      Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Acad Brasileira De Ciencias, 2009-09-01)
      Characterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse ...
    • B-1 cells facilitate Paracoccidioides brasiliensis infection in mice via IL-10 secretion 

      Popi, Ana Flavia [UNIFESP]; Godoy, Luiz Claudio [UNIFESP]; Xander, Patricia [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Elsevier B.V., 2008-06-01)
      Protective immunity in paracoccidioidomycosis is mainly mediated by cellular immunity. the role of B cells in this disease, in particular B-1 cells, is poorly understood. the aim of this study was to characterize the ...
    • B-1 cells modulate oral tolerance in mice 

      De-Gennaro, Luiz Antonio [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Almeida, Sandro Rogrio de; Lopes, Jose Daniel [UNIFESP]; Mariano, Mario [UNIFESP] (Elsevier B.V., 2009-06-04)
      Although the origin and functions of B-1 cells are controversial, they are considered as a cellular element of innate immunity due to their ability to produce natural autoantibodies of the IgM type. These antibodies are ...
    • B-1 cells produce insulin and abrogate experimental streptozotocin-induced diabetes 

      Alvares-Saraiva, Anuska M. [UNIFESP]; Novo, Marilia C. T. [UNIFESP]; Oliveira, Vivian Cristina de [UNIFESP]; Maricato, Juliana Terzi [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Mariano, Mario [UNIFESP] (Wiley-Blackwell, 2015-05-01)
      The participation of B-1 cells in a murine model of spontaneous diabetes has been recently reported. Here, we describe the role of B-1 cells in streptozotocin (STZ) induced diabetes in mice. We demonstrated that XID (B-1 ...
    • B-1 cells temper endotoxemic inflammatory responses 

      Barbeiro, Denise Frediani; Barbeiro, Hermes Vieira; Faintuch, Joel; Kubo Ariga, Suely K.; Mariano, Mario [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Souza, Heraldo Possolo de; Velasco, Irineu Tadeu; Soriano, Francisco Garcia (Elsevier B.V., 2011-03-01)
      Sepsis syndrome is caused by inappropriate immune activation due to bacteria and bacterial components released during infection. This syndrome is the leading cause of death in intensive care units. Specialized B-lymphocytes ...
    • B-1 lymphocytes differentiate into functional osteoclast-like cells 

      Pugliese, Livia Souza [UNIFESP]; Gonçalves-Zillo, Thais Oliveira [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Mariano, Mario [UNIFESP]; Pesquero, Joao Bosco [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Elsevier B.V., 2012-03-01)
      The existence of murine peritoneal osteoclast precursors has been already described. Also, recent reports evidenced an interplay between B lymphocytes and osteoclasts development. B-1 cells comprise a B-lymphocyte subset ...
    • B-1 lymphocytes increase metastatic behavior of melanoma cells through the extracellular signal-regulated kinase pathway 

      Perez, Elizabeth Cristina [UNIFESP]; Machado, Joel [UNIFESP]; Aliperti, Fabiana [UNIFESP]; Freymueller, Edna [UNIFESP]; Mariano, Mario [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Blackwell Publishing, 2008-05-01)
      Increasing evidence indicates that tumors require a constant influx of myelomonocytic cells to support their malignant behavior. This is caused by tumor-derived factors, which recruit and induce functional differentiation ...
    • B16 melanoma cells increase B-1 cell survival, IL-10 production and radioresistance in vitro 

      Lucatelli Laurindo, Maria Fernanda [UNIFESP]; Thies, Felipe Garutti [UNIFESP]; Perez, Elizabeth Cristina [UNIFESP]; Novaes e Brito, Ronni Romulo [UNIFESP]; Mariano, Mario [UNIFESP]; Popi, Ana Flavia [UNIFESP] (Elsevier B.V., 2013-04-01)
      B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. the role of both cell populations ...
    • Blockage of Wnt/beta-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro 

      Tavares Novo, Marilia Campos [UNIFESP]; Osugui, Lika [UNIFESP]; Reis, Vanessa Oliveira dos [UNIFESP]; Longo-Maugeri, Ieda Maria [UNIFESP]; Mariano, Mario [UNIFESP]; Popi, Ana Flavia [UNIFESP] (Elsevier B.V., 2015-01-01)
      The Wnt/beta-catenin signaling pathway has been shown to play an important role in controlling the proliferation, survival and differentiation of hematopoietic cells. Several Wnt/beta-catenin signaling components influence ...
    • Characterization of gp70 and anti-gp70 monoclonal antibodies in Paracoccidioides brasiliensis pathogenesis 

      Grosso, Daniela de Mattos [UNIFESP]; Almeida, Sandro Rogerio de; Mariano, Mario [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Amer Soc Microbiology, 2003-11-01)
      Paracoccidioidomycosis (PCM) is a systemic granulomatous mycosis whose agent is Paracoccidioides brasiliensis. in the culture supernatant, the fungus expresses glycoproteins of from 13 to 148 kDa. A cell surface glycoprotein ...
    • Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro 

      Popi, Ana F. [UNIFESP]; Motta, Fabiana L. T. [UNIFESP]; Mortara, Renato A. [UNIFESP]; Schenkman, Sergio [UNIFESP]; Lopes, Jose D. [UNIFESP]; Mariano, Mario [UNIFESP] (Wiley-Blackwell, 2009-01-01)
      We previously demonstrated that B-1b cells can undergo differentiation to acquire a mononuclear phagocyte phenotype upon attachment to substrate in vitro. Here we followed the expression of surface markers and transcription ...
    • Could a B-1 Cell Derived Phagocyte Be One of the Peritoneal Macrophages during LPS-Driven Inflammation? 

      Popi, Ana Flavia [UNIFESP]; Osugui, Lika [UNIFESP]; Perez, Katia Regina [UNIFESP]; Longo-Maugeri, Ieda Maria [UNIFESP]; Mariano, Mario [UNIFESP] (Public Library Science, 2012-03-30)
      The inflammatory response is driven by signals that recruit and elicit immune cells to areas of tissue damage or infection. the concept of a mononuclear phagocyte system postulates that monocytes circulating in the bloodstream ...
    • Cross Talk between Peritoneal Macrophages and B-1 Cells in Vitro 

      Thies, Felipe Garutti [UNIFESP]; Laurindo, Maria Fernanda Lucatelli [UNIFESP]; Perez, Elizabeth Cristina [UNIFESP]; Novaes e Brito, Ronni Romulo [UNIFESP]; Mariano, Mario [UNIFESP]; Popi, Ana Flavia [UNIFESP] (Public Library Science, 2013-05-08)
      B-1 cells constitute a distinct B cell population with unique phenotypic and functional characteristics. They represent the main B cell population found in mouse peritoneal and pleural cavities. the communication between ...
    • Crosstalk between B16 melanoma cells and B-1 lymphocytes induces global changes in tumor cell gene expression 

      Xander, Patricia [UNIFESP]; Novaes e Brito, Ronni Romulo; Perez, Elizabeth Cristina; Pozzibon, Jaqueline Maciel [UNIFESP]; Souza, Camila Ferreira de [UNIFESP]; Pellegrino, Renata [UNIFESP]; Bernardo, Viviane [UNIFESP]; Jasiulionis, Miriam Galvonas [UNIFESP]; Mariano, Mario [UNIFESP]; Lopes, Jose Daniel [UNIFESP] (Elsevier B.V., 2013-10-01)
      The analysis of gene expression patterns in cancers has improved the understanding of the mechanisms underlying the process of metastatic progression. However, the acquisition of invasive behavior in melanoma is poorly ...
    • Efeito da radiação ionizante sobre a região tóraco-abdominal na evolução do lúpus eritematoso sistêmico em camundongos (NZB/NZW)F1. Comportamento de células B-1 

      Brito, Ronni Romulo Novaes e [UNIFESP] (Universidade Federal de São Paulo (UNIFESP), 2002)
      Objetivo: Investigar se a irradiacao toraco-abdominal de camundongos induz bloqueio na evolucao do LES em camundongos (NZB/NZW)F1 e a possivel participacao de celulas B-1 no processo. Metodos: Camundongos femeos da linhagem ...