Now showing items 1-5 of 5

    • Electrochemical Reduction Using Glassy Carbon Electrode in Aqueous Medium of a Potential Anti-Chagas Drug: NFOH 

      La-Scalea, Mauro Aquiles [UNIFESP]; Trossini, G. H. G.; Menezes, C. M. S.; Chung, M. C.; Ferreira, E. I. (Electrochemical Soc Inc, 2009-01-01)
      Nitrofurazone (NF) presents activity against Chagas' disease, yet it has a high toxicity. Its analog, hydroxymethylnitrofurazone (NFOH), is more potent against Trypanosoma cruzi and much less toxic than the parent drug, ...

    • Electrochemical study of simple coumarin and its determination in aqueous infusion of Mikania glomerata 

      Miyano, Daniela Miwa [UNIFESP]; Lima, Thays [UNIFESP]; Simões, Fabio Ruiz [UNIFESP]; La-Scalea, Mauro Aquiles [UNIFESP]; Oliveira, Hueder P. M.; Codognoto, Lucia [UNIFESP] (Sociedade Brasileira de Química, 2014-03-01)
      The present study aims the development and application of an electrochemical method for simple coumarin determination in aqueous media by using a boron-doped diamond electrode (BDDE). The studies were carried out at pH 8.0 ...

    • Nitrofurazone and its nitroheterocyclic analogues: a study of the electrochemical behavior in aqueous medium 

      Brito, Charles de Lima; Trossini, Gustavo Henrique Goulart; Ferreira, Elizabeth Igne; La-Scalea, Mauro Aquiles [UNIFESP] (Sociedade Brasileira de Química, 2013-12-01)
      The biological action of drugs with potential antichagasic activities can be better understood by knowing their reduction mechanism. For this proposal, the electrochemical reduction of nitrofurazone (NF) and its analogues, ...

    • Redução voltamétrica de artemisinina e sua interação com grupo heme (hemina) 

      La-Scalea, Mauro Aquiles [UNIFESP]; Silva, Hélio Santa Rosa Costa; Ferreira, Elizabeth Igne (Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo, 2007-09-01)
      Malaria is the tropical disease most devastating of the world and this situation is worsened by the absence of effective treatment. However, the plasmodium resistance to artemisinin does not show clinical relevance. The ...

    • Square wave voltammetry of nitrofurans in aqueous media using a carbon fiber microelectrode 

      Chiavassa, Luisa Donatto [UNIFESP]; La-Scalea, Mauro Aquiles [UNIFESP] (Springer, 2018)
      The nitrofuran compounds exhibit a wide spectrum of biological action, and the understanding of their reduction mechanism can contribute to a better comprehension of their biological action. In this sense, the electrochemical ...