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    • Mutations of the PC2 substrate binding pocket alter enzyme specificity 

      Kacprzak, M. M.; Than, M. E.; Juliano, Luiz [UNIFESP]; Juliano, Maria Aparecida [UNIFESP]; Bode, W.; Lindberg, I (Amer Soc Biochemistry Molecular Biology Inc, 2005-09-09)
      By taking advantage of the recently published furin structure, whose catalytic domain shares high homology with other proprotein convertases, we designed mutations in the catalytic domain of PC2, altering residues Ser(206), ...