Browsing by Author "Camacho, Cleber P. [UNIFESP]"
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Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma
Nascimento, Fabricio P. [UNIFESP]; Cardoso, Mirian G. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Kunii, Ilda S. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Kizys, Marina M. L. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP] (Spandidos Publ Ltd, 2016)Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ... -
Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma
Nascimento, Fabricio P. [UNIFESP]; Cardoso, Mirian G. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Kunii, Ilda S. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Kizys, Marina M. L. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP] (Spandidos Publ Ltd, 2016)Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes ... -
Clinical and Molecular Analysis of Thyroid Hypoplasia: A Population-Based Approach in Southern Brazil
Ramos, Helton E. [UNIFESP]; Nesi-Franca, Suzana; Boldarine, Valter T. [UNIFESP]; Pereira, Rosana M.; Chiamolera, Maria Izabel [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Graf, Hans; Lacerda, Luiz de; Carvalho, Gisah A.; Maciel, Rui M. B. [UNIFESP] (Mary Ann Liebert, Inc, 2009-01-01)Background: Congenital hypothyroidism (CH) is mainly due to developmental abnormalities leading to thyroid dysgenesis (TD). TD encompasses very distinct morphologic subtypes of disease. This study examined and compared the ... -
Clinical impact of thyroglobulin (Tg) and Tg autoantibody (TgAb) measurements in needle washouts of neck lymph node biopsies in the management of patients with papillary thyroid carcinoma
Cecilia Martins-Costa, M. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Kasamatsu, Teresa S.; Nakabashi, Claudia C. D. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Crispim, Felipe [UNIFESP]; Ikejiri, Elza S. [UNIFESP]; Mamone, M. Conceicao O. [UNIFESP]; Andreoni, Danielle M. [UNIFESP]; Biscolla, Rosa Paula M. [UNIFESP] (Sbem-Soc Brasil Endocrinologia & Metabologia, 2017)Objectives: The presence of thyroglobulin (Tg) in needle washouts of fine needle aspiration biopsy (Tg-FNAB) in neck lymph nodes (LNs) suspected of metastasis has become a cornerstone in the followup of patients with ... -
Clinical utility of F-18-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma
Yang, Ji H. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Nakabashi, Claudia C. D. [UNIFESP]; Janovsky, Carolina C. P. S. [UNIFESP]; Padovani, Rosalia P. [UNIFESP]; Macellaro, Danielle [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Osawa, Akemi; Wagner, Jairo; Biscolla, Rosa Paula M. [UNIFESP] (Sbem-Soc Brasil Endocrinologia & Metabologia, 2017)Objective: To evaluate the clinical utility of F-18-FDG PET/CT in patients with high-risk DTC. Subjects and methods: Single-center retrospective study with 74 patients with high-risk differentiated thyroid cancer (DTC), ... -
THE COMBINED USE OF CALCITONIN DOUBLING TIME AND F-18-FDG PET/CT IMPROVES PROGNOSTIC VALUES IN MEDULLARY THYROID CARCINOMA: THE CLINICAL UTILITY OF F-18-FDG PET/CT
Yang, Ji H. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Andreoni, Danielle M. [UNIFESP]; Yamaga, Lilian Y.; Wagner, Jairo; Biscolla, Rosa Paula M. [UNIFESP]; Maciel, Rui M. B. [UNIFESP] (Amer Assoc Clinical Endocrinologists, 2017)Objective: Calcitonin and carcinoembryonic antigen (CEA) doubling times are established prognostic markers in medullary thyroid cancer (MTC). On the other hand, F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed ... -
Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility
Toledo, Rodrigo A.; Hatakana, Roxanne; Lourenco, Delmar M.; Lindsey, Susan C. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Almeida, Marcio; Lima, Jose V.; Sekiya, Tomoko; Garralda, Elena; Naslavsky, Michel S.; Yamamoto, Guilherme L.; Lazar, Monize; Meirelles, Osorio; Sobreira, Tiago J. P.; Lebrao, Maria Lucia; Duarte, Yeda A. O.; Blangero, John; Zatz, Mayana; Cerutti, Janete M. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Toledo, Sergio P. A. [UNIFESP] (Bioscientifica Ltd, 2015-02-01)Accurate interpretation of germline mutations of the rearranged during transfection (RET) proto-oncogene is vital for the proper recommendation of preventive thyroidectomy in medullary thyroid carcinoma (MTC)-prone carriers. ... -
Diagnóstico de metástases de carcinoma papilífero de tiróide através da dosagem de tiroglobulina no líquido obtido da lavagem da agulha utilizada na punção aspirativa
Biscolla, Rosa Paula M. [UNIFESP]; Ikejiri, Elza S. [UNIFESP]; Mamone, Maria Conceição [UNIFESP]; Nakabashi, Cláudia C.d. [UNIFESP]; Andrade, Victor P.; Kasamatsu, Teresa S. [UNIFESP]; Crispim, Felipe [UNIFESP]; Chiamolera, Maria Izabel [UNIFESP]; Andreoni, Danielle M. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Hojaij, Flávio C. [UNIFESP]; Vieira, José Gilberto H. [UNIFESP]; Furlanetto, Reinaldo P. [UNIFESP]; Maciel, Rui Monteiro de Barros [UNIFESP] (Sociedade Brasileira de Endocrinologia e Metabologia, 2007-04-01)The widespread use of neck ultrasonography (US) during the follow-up of patients with papillary thyroid carcinoma (PTC) has led to the discovery of small cervical lymph nodes (LN). Although US has a high sensitivity for ... -
Down-regulation of NR4A1 in follicular thyroid carcinomas is restored following lithium treatment
Camacho, Cleber P. [UNIFESP]; Latini, Flavia R. M. [UNIFESP]; Oler, Gisele [UNIFESP]; Hojaij, Flavio C. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Riggins, Gregory J.; Cerutti, Janete M. [UNIFESP] (Wiley-Blackwell, 2009-03-01)The identification of follicular thyroid adenoma-associated transcripts will lead to a better understanding of the events involved in pathogenesis and progression of follicular tumours. Using Serial Analysis of Gene ... -
Early diagnosis of multiple endocrine neoplasia type 2B: a challenge for physicians
Camacho, Cleber P. [UNIFESP]; Hoff, Ana O. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Signorini, Priscila S. [UNIFESP]; Valente, Flávia O. F. [UNIFESP]; Oliveira, Mariana N. L. [UNIFESP]; Kunii, Ilda S.; Biscolla, Rosa Paula M. [UNIFESP]; Cerutti, Janete Maria [UNIFESP]; Maciel, Rui Monteiro de Barros [UNIFESP] (Sociedade Brasileira de Endocrinologia e Metabologia, 2008-11-01)BACKGROUND: The hereditary form of medullary thyroid carcinoma may occur isolated as a familial medullary thyroid carcinoma (FMTC) or as part of Multiple Endocrine Neoplasia 2A (MEN2A) and 2B (MEN2B). MEN2B is a rare ... -
Evaluation of RET polymorphisms in a six-generation family with G533C RET mutation: specific RET variants may modulate age at onset and clinical presentation
Tamanaha, Rosana [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Pereira, Alexandre C.; Alvares da Silva, Adriana M.; Maciel, Rui M. B. [UNIFESP]; Cerutti, Janete M. [UNIFESP] (Wiley-Blackwell, 2009-07-01)P>ContextWe previously described a six-generation family with G533C RET mutation and medullary thyroid carcinoma, in the largest family reported do date. of particular interest, phenotype variability regarding the age of ... -
Ga-68-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with In-111-octreotide SPECT/CT and conventional imaging
Itaya Yamaga, Lilian Yuri; Cunha, Marcelo L.; Campos Neto, Guilherme C.; Garcia, Marcio R. T.; Yang, Ji H. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Wagner, Jairo; Funari, Marcelo B. G. (Springer, 2017)Purpose The aim of this study was to prospectively compare the detection rate of Ga-68-DOTATATE PET-CT with In-111-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased ... -
Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis
Oler, Gisele [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Hojaij, Flavio C. [UNIFESP]; Michaluart, Pedro; Riggins, Gregory J.; Cerutti, Janete M. [UNIFESP] (Amer Assoc Cancer Research, 2008-08-01)Purpose: To identify papillary thyroid carcinoma (PTC)-associated transcripts, we compared the gene expression profiles of three Serial Analysis of Gene Expression libraries generated from thyroid tumors and a normal thyroid ... -
Macrocalcitonin Is a Novel Pitfall in the Routine of Serum Calcitonin Immunoassay
Alves, Thalita G. [UNIFESP]; Kasamatsu, Teresa S. [UNIFESP]; Yang, Ji H. [UNIFESP]; Meneghetti, Maria Cecilia Z. [UNIFESP]; Mendes, Aline [UNIFESP]; Kunii, Ilda S. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Dias da Silva, Magnus R. [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Vieira, Jose Gilberto H. [UNIFESP]; Martins, Joao Roberto M. [UNIFESP] (Endocrine Soc, 2016)Context: Calcitonin (CT) is a sensitive marker of medullary thyroid carcinoma (MTC) and is used for primary diagnosis and follow-up after thyroidectomy. However, persistently elevated CT is observed even after complete ... -
Management of Graves' orbitopathy in Latin America: an international questionnaire study compared with Europe
Ramos, Helton E.; Diehl, Leandro A.; Camacho, Cleber P. [UNIFESP]; Perros, Petros; Graf, Hans; Latin Amer Thyroid Soc (Wiley-Blackwell, 2008-12-01)Management of Graves' orbitopathy (GO) and dysthyroid optic neuropathy (DON) continues to be challenging. Other surveys have been successful in elucidating trends in GO management. Knowledge of current practice by members ... -
Measurement of Calcitonin and Calcitonin Gene-Related Peptide mRNA Refines the Management of Patients with Medullary Thyroid Cancer and May Replace Calcitonin-Stimulation Tests
Camacho, Cleber P. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Melo, Maria Clara C. [UNIFESP]; Yang, Ji H. [UNIFESP]; Germano-Neto, Fausto [UNIFESP]; Valente, Flavia de O. F. [UNIFESP]; Lima, Thiago R. N. [UNIFESP]; Biscolla, Rosa Paula M. [UNIFESP]; Vieira, Jose G. H. [UNIFESP]; Cerutti, Janete M. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP]; Maciel, Rui M. B. [UNIFESP] (Mary Ann Liebert Inc, 2013-03-01)Background: Serum calcitonin (sCT) is the main tumor marker for medullary thyroid cancer (MTC), but it has certain limitations. Various sCT assays may have important intra-assay or interassay variation and may yield different ... -
One Month Is Sufficient for Urinary Iodine to Return to Its Baseline Value After the Use of Water-Soluble Iodinated Contrast Agents in Post-Thyroidectomy Patients Requiring Radioiodine Therapy
Padovani, Rosalia P. [UNIFESP]; Kasamatsu, Teresa S. [UNIFESP]; Nakabashi, Claudia C. D. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Andreoni, Danielle M. [UNIFESP]; Malouf, Eduardo Z. [UNIFESP]; Marone, Marilia M. S.; Maciel, Rui M. B. [UNIFESP]; Biscolla, Rosa Paula M. [UNIFESP] (Mary Ann Liebert Inc, 2012-09-01)Background: There is a concern regarding the use of iodinated contrast agents (ICA) for chest and neck computed tomography (CT) to localize metastatases in patients with differentiated thyroid cancer (DTC). This is because ... -
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy
Janovsky, Carolina Castro Porto Silva [UNIFESP]; Maciel, Rui M. B. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Padovani, Rosalia P. [UNIFESP]; Nakabashi, Claudia C. [UNIFESP]; Yang, Ji H. [UNIFESP]; Malouf, Eduardo Z. [UNIFESP]; Ikejiri, Elza S. [UNIFESP]; Mamone, M. Conceicao O. C. [UNIFESP]; Wagner, Jairo; Andreoni, Danielle M. [UNIFESP]; Biscolla, Rosa Paula M. [UNIFESP] (Future Sci Ltd, 2016)Objectives: To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). Study Design: We ... -
The RET p.G533C Mutation Confers Predisposition to Multiple Endocrine Neoplasia Type 2A in a Brazilian Kindred and Is Able to Induce a Malignant Phenotype in Vitro and in Vivo
Oliveira, Mariana N. L. [UNIFESP]; Hemerly, Jefferson P. [UNIFESP]; Bastos, Andre U. [UNIFESP]; Tamanaha, Rosana [UNIFESP]; Latini, Flavia R. M. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Impellizzeri, Anelise; Maciel, Rui M. B. [UNIFESP]; Cerutti, Janete M. [UNIFESP] (Mary Ann Liebert Inc, 2011-09-01)Background: We have previously described a p.G533C substitution in the rearranged during transfection (RET) oncogene in a large family with medullary thyroid carcinoma. Here, we explore the functional transforming potential ... -
A ten-year clinical update of a large RET p.Gly533Cys kindred with medullary thyroid carcinoma emphasizes the need for an individualized assessment of affected relatives
Signorini, Priscila S. [UNIFESP]; Franca, Maria Inez C. [UNIFESP]; Camacho, Cleber P. [UNIFESP]; Lindsey, Susan C. [UNIFESP]; Valente, Flavia O. F. [UNIFESP]; Kasamatsu, Teresa S. [UNIFESP]; Machado, Alberto L. [UNIFESP]; Salim, Camila P. [UNIFESP]; Delcelo, Rosana [UNIFESP]; Hoff, Ana O. [UNIFESP]; Cerutti, Janete M. [UNIFESP]; Dias-da-Silva, Magnus R. [UNIFESP]; Maciel, Rui M. B. [UNIFESP] (Wiley-Blackwell, 2014-02-01)Objective Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10years after the first description of this kindred, has provided an important set of clinical data for healthcare decision-ma ...