Introdução e Metodos: Este estudo foi composto por duas fases (Fases I e II), sendo que na primeira avaliou-se a funcao do eixo hipotalamo-pituitario-adrenal (HPA) durante a resposta ao estresse atraves da dosagem de ...

INTRODUCTION/OBJECTIVES: Controlled-release lithium formulations were developed to minimize elevated blood peaks, related to side-effects and intoxications. However, there is little information about the bioavailability ...

The authors perform a narrative review of literature. They describe epidemiological, biological, social, and psychological aspects linked to gender differences in depressions. There are several differences between sexes ...

Behavioral sensitization, defined as a progressive increase in the locomotor stimulant effects elicited by repeated exposure to drugs of abuse, has been used as an animal model for drug craving in humans. the mesoaccumbens ...

Study Objectives: Actigraphy is generally compared to polysomnography (PSG), which has been considered the gold standard for sleep studies. The objective of the present study was to evaluate the concordance between PSG and ...

In this paper, the authors review the status of psychosocial interventions within the general treatment for bipolar disorder. They have verified the scantiness of studies performed with adequate methodology to obtain ...

We report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described. Typical symptoms hypersomnia, ...

Objective: Melancholic depression is a lifetime diagnosis, typically with recurrent episodes. Melancholia, a syndrome with a long history and distinctive psychopathological features, is differentiated from major depression ...

New hippocampal neurons are continuously generated in the adult brain of several animal species. Several studies have demonstrated that a variety of enviromental factors, including stress, influence the proliferation of ...