Now showing items 1-20 of 21

    • Altered Glucose Homeostasis and Hepatic Function in Obese Mice Deficient for Both Kinin Receptor Genes 

      Barros, Carlos C. [UNIFESP]; Haro, Anderson [UNIFESP]; Russo, Fernanda J. V. P. [UNIFESP]; Schadock, Ines; Almeida, Sandro S. [UNIFESP]; Ribeiro, Rosane A.; Vanzela, Emerielle C.; Lanzoni, Valeria Pereira [UNIFESP]; Barros, Flavio C.; Moraes, Milton Rocha de [UNIFESP]; Mori, Marcelo A. [UNIFESP]; Bacurau, Reury Frank Pereira; Wurtele, Martin [UNIFESP]; Boschero, Antonio C.; Carneiro, Everardo M.; Bader, Michael; Pesquero, João Bosco [UNIFESP]; Araujo, Ronaldo C. [UNIFESP] (Public Library Science, 2012-07-19)
      The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and ...
    • Altered reactivity of gastric fundus smooth muscle in the mouse with targeted disruption of the kinin B(1) receptor gene 

      Barbosa, Ana M. R. B. [UNIFESP]; Felipe, Sandra A. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Kawamoto, Elisa M.; Carvalho, Maria H. C.; Scavone, Cristoforo; Pesquero, Joao B. [UNIFESP]; Shimuta, Suma I. [UNIFESP] (Elsevier B.V., 2009-05-01)
      Relaxing action of sodium nitroprusside (SNP) was significantly reduced in the stomach fundus of mice lacking the kinin B(1) receptor (B(1)(-/-)). Increased basal cGMP accumulation was correlated with attenuated SNP induced ...
    • Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis 

      Pereira, Rafael L. [UNIFESP]; Buscariollo, Bruna N. [UNIFESP]; Correa-Costa, Matheus; Semedo, Patricia [UNIFESP]; Oliveira, Cassiano D. [UNIFESP]; Reis, Vanessa O. [UNIFESP]; Maquigussa, Edgar [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Braga, Tarcio T.; Soares, Maria Fernanda Sanches [UNIFESP]; Moura, Ivan C.; Malheiros, Denise M. A. C.; Pacheco-Silva, Alvaro [UNIFESP]; Keller, Alexandre C. [UNIFESP]; Camara, Niels O. S. [UNIFESP] (Nature Publishing Group, 2011-06-01)
      Focal and segmental glomerulosclerosis (FSGS) is one of the most important causes of end-stage renal failure. the bradykinin B1 receptor has been associated with tissue inflammation and renal fibrosis. To test for a role ...
    • Caloric Restriction Is More Efficient than Physical Exercise to Protect from Cisplatin Nephrotoxicity via PPAR-Alpha Activation 

      Estrela, Gabriel R. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Batista, Rogerio O. [UNIFESP]; Hiyane, Meire I.; Felizardo, Raphael J. F. [UNIFESP]; Cunha, Flavia [UNIFESP]; de Almeida, Danilo C. [UNIFESP]; Malheiros, Denise M. A. C.; Camara, Niels O. S.; Barros, Carlos C.; Bader, Michael; Araujo, Ronaldo C. [UNIFESP] (Frontiers Media Sa, 2017)
      The antineoplastic drug cisplatin promotes renal injury, which limits its use. Protocols that reduce renal cisplatin toxicity will allow higher doses to be used in cisplatin treatment. Here, we compare physical exercise ...
    • Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon alpha 

      Navarro, Francisco; Bacurau, Aline V. N.; Vanzelli, Andrea; Meneguello-Coutinho, Marcela; Uchida, Marco C.; Moraes, Milton R. [UNIFESP]; Almeida, Sandro S. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Barros, Carlos C. [UNIFESP]; Wuertele, Martin [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Costa Rosa, Luis F. B.; Bacurau, Reury Frank Pereira (Hindawi Publishing Corporation, 2010-01-01)
      In lymphocytes (LY), the well-documented antiproliferative effects of IFN-alpha are associated with inhibition of protein synthesis, decreased amino acid incorporation, and cell cycle arrest. However, the effects of this ...
    • CHRONIC CONVENTIONAL RESISTANCE EXERCISE REDUCES BLOOD PRESSURE in STAGE 1 HYPERTENSIVE MEN 

      Moraes, Milton R. [UNIFESP]; Bacurau, Reury Frank Pereira; Casarini, Dulce E. [UNIFESP]; Jara, Zaira P. [UNIFESP]; Ronchi, Fernanda A. [UNIFESP]; Almeida, Sandro S. [UNIFESP]; Higa, Elisa M. S. [UNIFESP]; Pudo, Marcos A.; Rosa, Thiago S. [UNIFESP]; Haro, Anderson S. [UNIFESP]; Barros, Carlos C. [UNIFESP]; Pesquero, Joao B. [UNIFESP]; Wuertele, Martin [UNIFESP]; Araujo, Ronaldo C. [UNIFESP] (Lippincott Williams & Wilkins, 2012-04-01)
      Moraes, MR, Bacurau, RFP, Casarini, DE, Jara, ZP, Ronchi, FA, Almeida, SS, Higa, EMS, Pudo, MA, Rosa, TS, Haro, AS, Barros, CC, Pesquero, JB, Wurtele, M, and Araujo, RC. Chronic conventional resistance exercise reduces ...
    • Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation 

      Amorim, Carlos E. N. [UNIFESP]; Nogueira, Eliana [UNIFESP]; Almeida, Sandro S. [UNIFESP]; Gomes, Pedro P. G. [UNIFESP]; Bacurau, Reury Frank Pereira; Suzete Ozaki, K. [UNIFESP]; Cenedeze, Marcos A. [UNIFESP]; Pacheco-Silva, Alvaro [UNIFESP]; Câmara, Niels Olsen Saraiva [UNIFESP]; Araujo, Ronaldo C. [UNIFESP] (Walter de Gruyter & Co, 2013-03-01)
      There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but few studies have investigated their importance after renal ...
    • Effects of training and nitric oxide on diabetic nephropathy progression in type I diabetic rats 

      Rodrigues, Adelson M. [UNIFESP]; Bergamaschi, Cassia T. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Mouro, Margaret G. [UNIFESP]; Rosa, Thiago S. [UNIFESP]; Higa, Elisa M. S. [UNIFESP] (Royal Soc Medicine Press Ltd, 2011-10-01)
      The aim of the paper is to assess nitric oxide (NO) production during aerobic training and its role on the progression of diabetic nephropathy in rats. Induction of diabetes mellitus (DM) was achieved in adult male Wistar ...
    • Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet 

      Wasinski, Frederick [UNIFESP]; Bacurau, Reury Frank Pereira; Moraes, Milton R. [UNIFESP]; Haro, Anderson S. [UNIFESP]; Moraes-Vieira, Pedro M. M.; Estrela, Gabriel R. [UNIFESP]; Paredes-Gamero, Edgar J. [UNIFESP]; Barros, Carlos C.; Almeida, Sandro S. [UNIFESP]; Camara, Niels O. S.; Araujo, Ronaldo C. [UNIFESP] (Hindawi Publishing Corporation, 2013-01-01)
      As the size of adipocytes increases during obesity, the establishment of resident immune cells in adipose tissue becomes an important source of proinflammatory mediators. Exercise and caloric restriction are two important, ...
    • Exercise prevents the effects of experimental arthritis on the metabolism and function of immune cells 

      Navarro, Francisco; Bacurau, Alinc V. N.; Almejda, Sandro S. [UNIFESP]; Barros, Carlos C. [UNIFESP]; Moraes, Milton R. [UNIFESP]; Pesquero, Jorge L.; Ribeiro, Sandra M. L.; Araujo, Ronaldo C. [UNIFESP]; Costa Rosa, Luis F. B. P.; Bacurau, Reury Frank Pereira (Wiley-Blackwell, 2010-06-01)
      Active lymphocytes (LY) and macrophages (M Phi) are involved in the pathophysiology of rheumatoid arthritis (RA) Due to its anti-inflammatory effect. physical exercise may be beneficial in RA by acting on the immune system ...
    • Hematopoietic stem cell expansion caused by a synthetic fragment of leptin 

      Dias, Carol C. [UNIFESP]; Nogueira-Pedro, Amanda [UNIFESP]; Barbosa, Christiano M. V. [UNIFESP]; Ribeiro-Filho, Antonio C. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Oliveira, Vani Xavier de; Miranda, Antonio [UNIFESP]; Paredes-Gamero, Edgar J. [UNIFESP] (Elsevier B.V., 2013-12-01)
      Leptin is a cytokine that regulates food intake, energy expenditure and hematopoiesis. Based on the tridimensional structure of the human leptin molecule, six fragments have been synthesized, (Ac-Lep(23-47)-NH2, [LEP1]; ...
    • High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT(2) receptor-dependent mechanism 

      Morais, Rafael L. [UNIFESP]; Hilzendeger, Aline M. [UNIFESP]; Visniauskas, Bruna [UNIFESP]; Todiras, Mihail; Alenina, Natalia; Mori, Marcelo A. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Nakaie, Clovis R. [UNIFESP]; Chagas, Jair R. [UNIFESP]; Carmona, Adriana K. [UNIFESP]; Bader, Michael; Pesquero, Joao B. [UNIFESP] (Amer Physiological Soc, 2017)
      Obesity is assumed to be a major cause of human essential hypertension
    • Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers 

      Pontes, Francisco L. [UNIFESP]; Bacurau, Reury F. P. [UNIFESP]; Moraes, Milton R. [UNIFESP]; Navarro, Francisco; Casarini, Dulce E. [UNIFESP]; Pesquero, Jorge L.; Pesquero, Joao B.; Araujo, Ronaldo C. [UNIFESP]; Piçarro, Ivan da Cruz [UNIFESP] (Elsevier B.V., 2008-02-01)
      Previous studies demonstrated a reduction in blood pressure level immediately after different types of exercises, like running, cycling and resistance training, a phenomenon called post-exercise hypotension (PEH). Since ...
    • Kinin B-1 receptor stimulation modulates leptin homeostasis. Evidence for an insulin-dependent mechanism 

      Mori, Marcelo A. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Pesquero, Joao B. [UNIFESP] (Elsevier B.V., 2008-02-01)
      Kinins are potent vasoactive and inflammatory peptides generated by kallikreins in blood and tissues that bind to specific receptors named B-1 and B-2. On the other hand, leptin is an adipocytokine that displays broad ...
    • Kinin B-2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury 

      Estrela, Gabriel R. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Bacurau, Reury Frank Pereira; Malheiros, Denise M. A. C.; Camara, Niels O. S.; Araujo, Ronaldo C. [UNIFESP] (Elsevier B.V., 2014-09-01)
      Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the ...
    • Kinin B1 receptor deficiency attenuates cisplatin-induced acute kidney injury by modulating immune cell migration 

      Estrela, Gabriel R. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Almeida, Danilo C. [UNIFESP]; Amano, Mariane T.; Castoldi, Angela; Dias, Carolina C. [UNIFESP]; Malheiros, Denise M. A. C.; Almeida, Sandro S. [UNIFESP]; Paredes-Gamero, Edgar J. [UNIFESP]; Pesquero, Joao B. [UNIFESP]; Barros, Carlos C. [UNIFESP]; Camara, Niels O. S.; Araujo, Ronaldo C. [UNIFESP] (Springer, 2014-04-01)
      Cisplatin is a chemotherapeutic agent that causes severe renal dysfunction. the kinin B1 receptor has been associated with the migration of immune cells to injured tissue as well as with renal inflammation. To examine the ...
    • Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise 

      Wasinski, Frederick [UNIFESP]; Gregnani, Marcos F.; Ornellas, Fabio H.; Bacurau, Aline V. N.; Camara, Niels O. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Bacurau, Reury F. P. [UNIFESP] (Hindawi Publishing Corporation, 2014-01-01)
      Glucose and glutamine are important energetic and biosynthetic nutrients for T and B lymphocytes. These cells consume both nutrients at high rates in a function-dependentmanner. in other words, the pathways that control ...
    • MATE-1 modulation by kinin B1 receptor enhances cisplatin efflux from renal cells 

      Estrela, Gabriel R. [UNIFESP]; Wasinski, Frederick [UNIFESP]; Felizardo, Raphael J. F. [UNIFESP]; Souza, Laura L.; Camara, Niels O. S.; Bader, Michael; Araujo, Ronaldo C. [UNIFESP] (Springer, 2017)
      Cisplatin is a drug widely used in chemotherapy that frequently causes severe renal dysfunction. Organic transporters have an important role to control the absorption and excretion of cisplatin in renal cells. Deletion and ...
    • Modification of Epigenetic Patterns in Low Birth Weight Children: Importance of Hypomethylation of the ACE Gene Promoter 

      Rangel, Marina [UNIFESP]; Santos, Jessica Cassilla dos; Ortiz, Paula Helena Lima; Hirata, Mario; Jasiulionis, Miriam Galvonas [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Ierardi, Daniela Filippini; Franco, Maria do Carmo [UNIFESP] (Public Library Science, 2014-08-29)
      There is a growing body of evidence that epigenetic alterations are involved in the pathological mechanisms of many chronic disorders linked to fetal programming. Angiotensin-converting enzyme (ACE) appears as one candidate ...
    • Myelopoiesis modulation by ACE hyperfunction in kinin B-1 receptor knockout mice: Relationship with AcSDKP levels 

      Oliveira, Carlos R. [UNIFESP]; Paredes-Gamero, Edgar J. [UNIFESP]; Barbosa, Christiano M. V. [UNIFESP]; Nascimento, Fabio D. [UNIFESP]; Batista, Elice C. [UNIFESP]; Reis, Felipe C. G. [UNIFESP]; Martins, Antonio H. B. [UNIFESP]; Ferreira, Alice T. [UNIFESP]; Carmona, Adriana K. [UNIFESP]; Pesquero, Joao B. [UNIFESP]; Tersariol, Ivarne L. S. [UNIFESP]; Araujo, Ronaldo C. [UNIFESP]; Bincoletto, Claudia [UNIFESP] (Elsevier B.V., 2010-03-30)
      Angiotensin I-converting enzyme (ACE), a common element of renin-angiotensin system (RAS) and kallikrein-kinin system (KKS), is involved in myelopoiesis modulation, mainly by cleaving the tetrapeptide N-acetyl-seryl-aspa ...