Navegando por Palavras-chave "vitamin E"
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- ItemAcesso aberto (Open Access)An alternative non-invasive treatment for Peyronie's disease(Sociedade Brasileira de Urologia, 2004-06-01) Claro, Joaquim A. [UNIFESP]; Passerotti, Carlo Camargo [UNIFESP]; Figueiredo Neto, Antonio C. [UNIFESP]; Nardozza Júnior, Archimedes [UNIFESP]; Ortiz, Valdemar [UNIFESP]; Srougi, Miguel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: Surgical correction of the deformity and plaque caused by Peyronie's disease has some important disadvantages and extracorporeal shockwave therapy (ESWT) emerged as a new promising therapy. We evaluated prospectively the efficacy and safety of the association of high dose vitamin E and ESWT as a non-invasive treatment for the disease. MATERIALS AND METHODS: Twenty-five patients 42 to 68 years old (mean = 54) presenting penile deviation and sexual distress caused by Peyronie's disease were treated in a non-invasive manner. The time of penile deviation ranged from 16 to 52 months (mean = 30). All patients had previous unsuccessful treatment for Peyronie's disease. The angulation's deformity of the penis was assessed by photography at home. The patients received vitamin E (l.200 mg daily) during 3 months and underwent 3 to 6 sessions (mean = 3) of ESWT (3,000 to 4,000 shockwaves) at a power level of l to 2 at 1-week intervals. RESULTS: From 25 patients treated, 16 (64%) reported an improvement in penile angulation, with a mean reduction of 21 degrees (10 to 40). Eight patients reported improvement in their spontaneous erections. Overall, the patients presented only minimal bruising at the site of treatment and skin hematoma. Four patients presented urethral bleeding. The mean angulation after treatment in the control group was 48.67 degrees (30 - 70) and in the study group was 24.42 degrees (0 - 70), statistically significant. CONCLUSION: Considering the common complications and the unsatisfactory outcome of the surgical correction for Peyronie's disease, the association of high dose vitamin E and ESWT represents a good option for a non-invasive, effective and safe treatment of the penile deformity.
- ItemSomente MetadadadosAntioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: a randomized, double-blind, placebo-controlled trial(Wiley-Blackwell, 2013-03-01) Arruda, Martha M. [UNIFESP]; Mecabo, Grazielle [UNIFESP]; Rodrigues, Celso A. [UNIFESP]; Matsuda, Sandra S. [UNIFESP]; Rabelo, Iara B. [UNIFESP]; Figueiredo, Maria S. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Erythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts of pro-oxidants than normal cells. Oxidative stress seems to primarily affect the membrane and results in haemolysis. the use of antioxidants in vitro reduces the generation of pro-oxidants. To evaluate the impact of vitamins C (VitC) and E (VitE) supplementation in SCA patients, patients over 18years were randomly assigned to receive VitC 1400mg+VitE 800mg per day or placebo orally for 180d. Eighty-three patients were enrolled (44 vitamins, 39 placebo), median age 27 (1868) years, 64% female. There were no significant differences between the two groups regarding clinical complications or baseline laboratorial tests. Sixty percent of the patients were VitC deficient, 70% were VitE deficient. Supplementation significantly increased serum VitC and E. However, no significant changes in haemoglobin levels were observed, and, unexpectedly, there was a significant increase in haemolytic markers with vitamin supplementation. in conclusion, VitC+VitE supplementation did not improve anaemia and, surprisingly, increased markers of haemolysis in patients with SCA and S-0-thalassaemia. the exact mechanisms to explain this findings and their clinical significance remain to be determined.
- ItemAcesso aberto (Open Access)Concentrações de vitaminas C e E em pacientes com ataxia telangiectasia: relação com biomarcadores associados a aterosclerose e ao estresse oxidativo.(Universidade Federal de São Paulo (UNIFESP), 2013) Andrade, Itana Gomes Alves [UNIFESP]; Sarni, Roseli Oselka Saccardo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introdução: A ataxia telangiectasia (AT) e uma doenca neurodegenerativa, que cursa com imunodefiCiência em graus variaveis, disfuncao mitocondrial e exacerbacao do estresse oxidativo. Objetivo: avaliar o estado nutricional, perfil lipidico, peroxidacao lipidica e as concentracoes plasmaticas de vitaminas C e E e relaciona-las com biomarcadores associados ao risco de aterosclerose de pacientes com AT e controles. Metodos: Estudo transversal controlado envolvendo 13 pacientes e 22 controles saudaveis, pareados por genero e idade. Foram avaliados: estado nutricional, consumo alimentar, perfil lipidico e suas relacoes, concentracoes plasmaticas de vitaminas C e E, malondialdeido (MDA) e proteina C reativa ultrassensivel (PCRus). Resultados: A media de idade do grupo AT foi 14,6 anos; 4/13 (30,8%) eram desnutridos e 3/13 (23,1%) apresentavam baixa estatura para idade. Os pacientes apresentaram maior comprometimento de massa magra comparativamente aos controles. As concentracoes de triglicerides, colesterol total e de LDL-c foram significantemente mais elevadas nos pacientes e as de HDL-c, mais baixas. As relacoes associadas ao risco de aterosclerose (CT/HDL-c, LDL-c/HDL-c e Log TG/HDL-c) e o colesterol nao HDL (NHDL-c) foram significantemente superiores no grupo de pacientes em comparacao aos controles. Nao houve diferenca para as concentracoes de malondialdeido, proteina C reativa e de vitaminas C e E entre os dois grupos. As relacoes vitamina E/lipideos totais e vitamina E/triglicerides mostraram valores mais baixos no grupo de pacientes; correlacao significante e inversa entre estas relacoes e NHDL-c, CT/HDL-c, LDL-c/HDL-c e Log TG/HDL-c foi observada no grupo de pacientes. A alanina aminotransferase (ALT) correlacionou-se de forma direta e significante com NHDL-c, CT/HDL-c e LDL-c/HDL-c, no grupo de pacientes. A inGestão dietetica de energia, macronutrientes e de vitaminas C e E nao diferiu entre os grupos. Conclusao: O elevado risco aterosclerotico de pacientes com AT aliado ao comprometimento da defesa antioxidante e do estado nutricional pode complicar a evolucao da doenca e enfatiza a importancia da atencao multiprofissional com monitoramento de biomarcadores e orientacao nutricional apropriada
- ItemSomente MetadadadosEffect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress(Wiley, 2018) Adami, L. N. G. [UNIFESP]; Belardin, Larissa Berloffa [UNIFESP]; Lima, B. T. [UNIFESP]; Jeremias, J. T. [UNIFESP]; Antoniassi, Mariana Pereira [UNIFESP]; Okada, Fatima Kazue [UNIFESP]; Bertolla, Ricardo Pimenta [UNIFESP]The aim of this study was to evaluate the antioxidant effect of in vitro supplementation with vitamin E in human spermatozoon incubated with an oxidative stress inducer. In this study, semen samples from 30 patients were collected and with one aliquot we performed semen analysis according to WHO. The remaining volume was divided into four aliquots: group C: incubated with BWW medium
- ItemSomente MetadadadosVitamin E attenuates reserpine-induced oral dyskinesia and striatal oxidized glutathione/reduced glutathione ratio (GSSG/GSH) enhancement in rats(Elsevier B.V., 2003-02-01) Abilio, Vanessa C. [UNIFESP]; Araujo, Carlos CS [UNIFESP]; Bergamo, Marcelo [UNIFESP]; Calvente, Patricia RV [UNIFESP]; D'Almeida, Vania [UNIFESP]; Ribeiro, Rosana de A. [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The effects of a previous and concomitant treatment with vitamin E (VE) were studied on an animal model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats treated with reserpine (RE). VE (5, 10, 20 or 40 mg/kg administered intraperitoneally, daily, for 19 days) attenuated the increase in tongue protrusion frequency induced by RE (1 mg/kg administered subcutaneously, on Days 16 and 18, 1 h after VE), which was quantified on Day 19. in a second experiment, a similar treatment with 20 mg/kg VE attenuated RE-induced increase in the striatal ratio of oxidized/reduced glutathione (GSSG/GSH), an index of the oxidative stress process. These results support the free radical hypothesis of tardive dyskinesia. (C) 2002 Elsevier Science Inc. All rights reserved.
- ItemSomente MetadadadosVitamin E prevents cell death induced by mild oxidative stress in chicken skeletal muscle cells(Elsevier B.V., 2005-07-01) Nunes, Viviane A. [UNIFESP]; Gozzo, Andrezza Justino [UNIFESP]; Cruz-Silva, Ilana [UNIFESP]; Juliano, Maria Aparecida [UNIFESP]; Viel, Tania A. [UNIFESP]; Godinho, Rosely O. [UNIFESP]; Meirelles, Flavio V.; Sampaio, Misako U. [UNIFESP]; Sampaio, Claudio A M [UNIFESP]; Araujo, Mariana S. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Apoptosis and necrosis are two forms of cell death that can occur in response to various agents and oxidative damage. in addition to necrosis, apoptosis contributes to muscle fiber loss in various muscular dystrophies as well participates in the exudative diathesis in chicken, pathology caused by dietary deficiency of vitamin E and selenium, which affects muscle tissue. We have used chicken skeletal muscle cells and bovine fibroblasts to study molecular events involved in the cell death induced by oxidative stress and apoptotic agents. the effect of vitamin E on cell death induced by oxidants was also investigated. Treatment of cells with anti-Fas antibody (50 to 400 ng/mL), staurosporine (0.1 to 100 mu M) and TNF-alpha (10 and 50 ng/mL) resulted in a little loss of Trypan blue exclusion ability. Those stimuli conducted cells to apoptosis detected by an enhancement in caspase activity upon fluorogenic substrates but this activity was not fully blocked by the caspase inhibitor Z-VAD-fmk. Oxidative stress induced by menadione (10, 100 and 250 mu M) promoted a significant reduction in cell viability (10%, 20% and 35% for fibroblasts; 20%, 30% and 75% for muscle cells, respectively) and caused an increase in caspase activity and DNA fragmentation. H2O2 also promoted apoptosis verified by caspase activation and DNA fragmentation, but in higher doses induced necrosis. Vitamin E protected cells from death induced by low doses of oxidants. Although it was ineffective in reducing caspase activity in fibroblasts, this vitamin diminished the enzyme activity in muscle cells. These data suggested that oxidative stress could activate apoptotic mechanisms; however the mode of cell death will depend on the intensity and duration of the stimulus, and on the antioxidant status of the cells. (C) 2005 Elsevier Inc. All rights reserved.