Navegando por Palavras-chave "vascular dementia"

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    Depressão vascular no idoso: resposta ao tratamento antidepressivo associado a inibidor das colinesterases
    (Faculdade de Medicina da Universidade de São Paulo, 2007-01-01) Barcelos, Ricardo; Faria, Juliano [UNIFESP]; Grossi, Paulo; Aparício, Marco Antonio Moscoso; Bottino, Cássio M. C.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Hospital Geral Santa Lúcia Centro de Terapia Intensiva
    CONTEXT: Among neuropsychiatric disorders caused by cerebrovascular factors, vascular depression is diagnosed in a small degree by general practitioners, causing morbid-mortality increase in elderly. CASE REPORT: That is a case of a 67 year-old-man with partial response after treatment with a Selective Serotonin Receptors Inhibitor, and severe autonomic adverse effects with other antidepressants. The addition of rivastigmine to citalopram resulted in a therapeutic success, with a reduction of 23 to 7 points on the Hamilton Depressive Scale (HAM-D). DISCUSSION: The result obtained brings new perspectives to the treatment of vascular depression, providing that randomized controlled trials with larger sample sizes confirm the positive effect of the addition of a cholinesterase inhibitor to antidepressants in the treatment of these patients.
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    Neuropsychological performance in patients with subcortical stroke
    (Academia Brasileira de Neurologia - ABNEURO, 2012-05-01) Andrade, Silviane Pinheiro Campos de [UNIFESP]; Brucki, Sônia Maria Dozzi; Bueno, Orlando Francisco Amodeo [UNIFESP]; Siqueira Neto, José Ibiapina; Universidade Federal de São Paulo (UNIFESP)
    Vascular cognitive impairment (VCI) is characterized by cognitive compromise predominantly of executive dysfunction. OBJECTIVES: To assess cognitive functions in VCI, focusing on executive functions, to observe functional losses in relation to activities of daily living (ADLs) and to detect early symptoms prior to the onset of dementia. METHODS: We evaluated healthy subjects matched for gender, education and age to patients with diagnosis of subcortical vascular disease who had a stroke classified into three groups: 1) vascular lesions and no impairment; 2) vascular cognitive impairment with no dementia (VCIND); 3) vascular dementia (VaD). RESULTS AND DISCUSSION: The performance on neuropsychological tests differed among groups, worsening with increased impairment level. The probable VaD group demonstrated impaired performance in memory, processing speed and verbal production, while the VCIND group showed attention deficits. CONCLUSION: Impairment in executive functions and difficulties in ADLs allow us to differentiate levels of impairment in groups of subcortical vascular disease.
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    Tobacco use and dementia: evidence from the 1066 dementia population-based surveys in Latin America, China and India
    (Wiley-Blackwell, 2011-11-01) Ferri, Cleusa P.; West, Robert; Moriyama, Tais S. [UNIFESP]; Acosta, Daisy; Guerra, Mariella; Huang, Yueqin; Jacob, K. S.; Ribeiro, Wagner [UNIFESP]; Llibre de Rodriguez, Juan J.; Salas, Aquiles; Luisa Sosa, Ana; Williams, Joseph; Acosta, Isaac; Liu, Zhaouri; Guerra Hernandez, Milagros A.; Prince, Martin J.; Kings Coll London; UCL; Universidade Federal de São Paulo (UNIFESP); Univ Nacl Pedro Henriquez Urena; Univ Peruana Cayetano Heredia; Peking Univ; Christian Med Coll & Hosp; Med Univ Havana; Caracas Univ Hosp; Natl Inst Neurol & Neurosurg Mexico; VHS; Policlin Univ 27 Noviembre
    Objectives: To assess the association between tobacco consumption and dementia using the same methodology in seven developing countries, testing the specific hypotheses that higher exposure to tobacco is associated with a higher prevalence of dementia, that the association is limited to smoked tobacco and is stronger for vascular dementia compared to Alzheimer's disease.Methods: Cross-sectional surveys conducted on individuals aged 65+. A total of 15 022 residents in specified catchment areas were assessed face-to-face using a standardised protocol, which included dementia diagnosis and detailed information on past and current tobacco consumption, and on important potential confounders of this association.Results: A high proportion of participants were never smokers (52% in Dominican Republic to 83% in Peru), most of those who ever used tobacco in China and India were still smoking at age 65 and above (80% and 84%, respectively). There was a positive association between history of tobacco smoke exposure (pack years up to age 50) and dementia (pooled PR = 1.003; 95% CI 1.001-1.005), Alzheimer's disease (pooled PR = 1.007; 95% CI, 1.003-1.011) and Vascular Dementia (pooled PR = 1.003; 95% CI = 1.001-1.005). These associations were attenuated but remained significant if exposure after the age of 50 was included. in India there was no association between smokeless tobacco and dementia.Conclusions: Dementia in developing countries appears to be positively associated with history of tobacco smoking but not smokeless tobacco use. Selective quitting in later life may bias estimation of associations. Copyright (C) 2011 John Wiley & Sons, Ltd.