Navegando por Palavras-chave "variability"

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    A dependência entre a condutividade hidráulica saturada e atributos físicos do solo
    (Universidade Federal de Santa Maria, 2004-06-01) Mesquita, Maria Da Glória Bastos De Freitas; Moraes, Sergio Oliveira [UNIFESP]; Universidade Federal de Lavras Departamento de Ciência do Solo; Universidade Federal de São Paulo (UNIFESP)
    The saturated hydraulic conductivity of the soil (Ksat) is one of the most relevant variables for studies concerning water and solutes movement in soil. Its determination in laboratory and field gives results with high dispersion, indicating that this property is highly variable. The Ksat is also dependent of other soil properties, mainly soil density, particles density, total porosity, micro porosity and macro porosity. A characterization and a larger understanding of this dependence becomes fundamental to allow any conclusions on the soils processes. The aim of this work was to explain the influence of these properties on Ksat and on water and solute movement in soils. A previous statistical characterization of the variables reveals that they can have different frequency distributions than Ksat, implicating in different variability and number of samples necessary to draw conclusions with the same reliability. Therefore, researchers should evaluate the risk in the estimate of dependent measures of Ksat and values they adopt for the properties of the soil for to be used in operations of agricultural practices.
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    Evaluation of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) classification scheme for diagnosis of cutaneous melanocytic neoplasms: Results from the International Melanoma Pathology Study Group
    (Mosby-Elsevier, 2016) Lott, Jason P.; Elmore, Joann G.; Zhao, Ge A.; Knezevich, Stevan R.; Frederick, Paul D.; Reisch, Lisa M.; Chu, Emily Y.; Cook, Martin G.; Duncan, Lyn M.; Elenitsas, Rosalie; Gerami, Pedram; Landman, Gilles [UNIFESP]; Lowe, Lori; Messina, Jane L.; Mihm, Martin C.; van den Oord, Joost J.; Rabkin, Michael S.; Schmidt, Birgitta; Shea, Christopher R.; Yun, Sook Jung; Xu, George X.; Piepkorn, Michael W.; Elder, David E.; Barnhill, Raymond L.
    Background: Pathologists use diverse terminology when interpreting melanocytic neoplasms, potentially compromising quality of care. Objective: We sought to evaluate the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis (MPATH-Dx) scheme, a 5-category classification system for melanocytic lesions. Methods: Participants (n = 16) of the 2013 International Melanoma Pathology Study Group Workshop provided independent case-level diagnoses and treatment suggestions for 48 melanocytic lesions. Individual diagnoses (including, when necessary, least and most severe diagnoses) were mapped to corresponding MPATH-Dx classes. Interrater agreement and correlation between MPATH-Dx categorization and treatment suggestions were evaluated. Results: Most participants were board-certified dermatopathologists (n = 15), age 50 years or older (n = 12), male (n = 9), based in the United States (n = 11), and primary academic faculty (n = 14). Overall, participants generated 634 case-level diagnoses with treatment suggestions. Mean weighted kappa coefficients for diagnostic agreement after MPATH-Dx mapping (assuming least and most severe diagnoses, when necessary) were 0.70 (95% confidence interval 0.68-0.71) and 0.72 (95% confidence interval 0.71-0.73), respectively, whereas correlation between MPATH-Dx categorization and treatment suggestions was 0.91. Limitations: This was a small sample size of experienced pathologists in a testing situation. Conclusion: Varying diagnostic nomenclature can be classified into a concise hierarchy using the MPATH-Dx scheme. Further research is needed to determine whether this classification system can facilitate diagnostic concordance in general pathology practice and improve patient care.
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    Randomized crossover study to assess the inter- and intrasubject variability of morning mycophenolic acid concentrations from enteric-coated mycophenolate sodium and mycophenolate mofetil in stable renal transplant recipients
    (Wiley-Blackwell, 2010-07-01) Tedesco-Silva, Helio [UNIFESP]; Felipe, Claudia R. [UNIFESP]; Park, Sung I. [UNIFESP]; Pinheiro-Machado, Paula G. [UNIFESP]; Garcia, Riberto [UNIFESP]; Slade, Alan; Schmouder, Robert; Medina-Pestana, Jose O. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Novartis Pharmaceut
    The delayed release of mycophenolic acid (MPA) from enteric-coated mycophenolate sodium (EC-MPS, myfortic (R)) may have an impact on the variability of MPA trough (C(0 h)) levels. A randomized, two-period crossover study was performed in 24 maintenance renal transplants to evaluate the inter- and intrasubject variability of MPA predose levels from EC-MPS and mycophenolate mofetil (MMF, CellCept (R)), both in combination with cyclosporine. Patients received EC-MPS (720 mg b.i.d.) and MMF (1000 mg b.i.d.) for a period of 21 d each. MPA plasma levels were measured over the final seven consecutive days at -1, 0, 1, 2, and 3 h after the morning MPA dose. Intersubject coefficients of variation (%CV) for MPA troughs were 47.5% (95% CI, 34.1-80.3) and 54.4% (40.0-86.8) for EC-MPS and MMF, respectively; intrasubject %CVs were 62.7% (55.1-72.9) and 42.8% (37.9-49.2). High MPA C(0 h) levels > 10 mu g/mL were rarely observed with both EC-MPS (1.8%) and MMF (0.6%). Mean MPA area under the curve (AUC)(0-3 h) was comparable between treatments, while MPA C(0 h) was on average 46% higher with EC-MPS. in conclusion, predose MPA trough level monitoring appears of limited value during EC-MPS and MMF therapy given the large intrasubject variability in MPA C(0 h) levels with both treatments.
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    The variability of the apnoea-hypopnoea index
    (Blackwell Science Ltd, 2001-09-01) Bittencourt, Lia Rita Azeredo [UNIFESP]; Suchecki, Deborah [UNIFESP]; Tufik, Sergio [UNIFESP]; Peres, Clovis de Araujo [UNIFESP]; Togeiro, Sonia Maria [UNIFESP]; Bagnato, Maurício da Cunha [UNIFESP]; Nery, Luiz Eduardo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    This study was designed to evaluate the variability of the apnoea-hypopnoea index (AHI) in 20 patients with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and to determine possible relationships of this variability with other polysomnographic parameters. the subjects were recorded on four consecutive nights. the mean AHI values were not significantly altered throughout the four recording nights (P = 0.67). the intraclass correlation coefficient of the AHI on the four nights was 0.92. However, the Bland and Altman plot showed that, individually, the AHI presented an important variability, which was not related to its initial value. in regard to the OSAHS severity, 50% of the patients changed the classification from the first to the subsequent nights. Thirteen of the 20 patients (65%) presented a variation in the AHI value equal or higher than 10 events h(-1). When we evaluated the AHI mean values for a specific body position and sleep stage, no difference was observed among the nights. in both supine and lateral-ventral decubitus, higher AHI was observed during Stages 1 and 2 than the other stages. Additionally, the AHI during Stages I and 2 and REM sleep was higher on the supine than on the lateral-ventral decubitus. the AHI in OSAHS patients presented a good correlation among the four recording nights; however, a significant individual variability should be considered, especially when AHI is applied in OSAHS classification or as a criterion of therapeutic success.