Repositório Institucional - Unifesp :: Navegando por Palavras-chave "vaccination"

Navegando por Palavras-chave "vaccination"

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Anti-bevacizumab idiotype antibody vaccination is effective in inducing vascular endothelial growth factor-binding response, impairing tumor outgrowth
(Wiley, 2016) Sanches, Jessica de Souza [UNIFESP]; Aguiar, Rodrigo Barbosa de [UNIFESP]; Parise, Carolina Bellini [UNIFESP]; Suzuki, Juliana Mayumi [UNIFESP]; Chammas, Roger [UNIFESP]; Moraes, Jane Zveiter de [UNIFESP]
Tumors require blood supply and, to overcome this restriction, induce angiogenesis. Vascular endothelial growth factor (VEGF) plays an important role in this process, which explains the great number of antiangiogenic therapies targeting VEGF. The research and development of targeted therapy has led to the approval of bevacizumab, a humanized anti-VEGF monoclonal antibody (mAb), in clinical settings. However, side effects have been reported, usually as a consequence of bolus-dose administration of the antibody. This limitation could be circumvented through the use of anti-idiotype (Id) antibodies. In the present study, we evaluated the efficacy of an active VEGF-binding immune response generated by an anti-bevacizumab idiotype mAb, 10.D7. The 10.D7 anti-Id mAb vaccination led to detectable levels of VEGF-binding anti-anti-Id antibodies. In order to examine whether this humoral immune response could have implications for tumor development, 10.D7-immunized mice were challenged with B16-F10 tumor cells. Mice immunized with 10.D7 anti-Id mAb revealed reduced tumor growth when compared to control groups. Histological analyses of tumor sections from 10.D7-immunized mice showed increased necrotic areas, decreased CD31-positive vascular density and reduced CD68-positive cell infiltration. Our results encourage further therapeutic studies, particularly if one considers that the anti-Id therapeutic vaccination maintains stable levels of VEGF-binding antibodies, which might be useful in the control of tumor relapse.
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Antibody response after vaccination with tetanus and diphtheria toxoids in human T-cell lymphotropic virus type 1 asymptomatic carriers
(Elsevier B.V., 2008-06-02) Biasutti, Claudia; Moraes-Pinto, Maria Isabel [UNIFESP]; Segurado, Aluisio C.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
Acesso aberto (Open Access)
The cost-effectiveness of influenza vaccination for people aged 50 to 64 years: An international model
(Blackwell Publishing, 2007-03-01) Aballea, Samuel; Chancellor, Jeremy; Martin, Monique; Wutzler, Peter; Carrat, Fabrice; Gasparini, Roberto; Toniolo Neto, João [UNIFESP]; Drummond, Michael; Weinstein, Milton; I3 Innovus; Univ Jena; INSERM; Univ Genoa; Universidade Federal de São Paulo (UNIFESP); Univ York; Harvard Univ
Objectives: Routine influenza vaccination is currently recommended in several countries for people aged more than 60 or 65 years or with high risk of complications. A lower age threshold of 50 years has been recommended in the United States since 1999. To help policymakers consider whether such a policy should be adopted more widely, we conducted an economic evaluation of lowering the age limit for routine influenza vaccination to 50 years in Brazil, France, Germany, and Italy.Methods: the probabilistic model was designed to compare in a single season the costs and clinical outcomes associated with two alternative vaccination policies for persons aged 50 to 64 years: reimbursement only for people at high risk of complications (current policy), and reimbursement for all individuals in this age group (proposed policy). Two perspectives were considered: third-party payer (TPP) and societal. Model inputs were obtained primarily from the published literature and validated through expert opinion. the historical distribution of annual influenza-like illness (ILI) incidence was used to simulate the uncertain incidence in any given season. We estimated gains in unadjusted and quality-adjusted life expectancy, and the cost per quality-adjusted life-year (QALY) gained. Deterministic and probabilistic sensitivity analyses were conducted.Results: Comparing the proposed to the current policy, the estimated mean costs per QALY gained were R$4,100, 13,200, 31,400 and 15,700 for Brazil, France, Germany, and Italy, respectively, from a TPP perspective. From the societal perspective, the age-based policy is predicted to yield net cost savings in Germany and Italy, whereas the cost per QALY decreased to R$2800 for Brazil and 8000 for France. the results were particularly sensitive to the ILI incidence rate, vaccine uptake, influenza fatality rate, and the costs of administering vaccination. Assuming a cost-effectiveness threshold ratio of 50,000 per QALY gained, the probabilities of the new policy being cost-effective were 94% and 95% for France, 72% and near 100% for Germany, and 89% and 99% for Italy, from the TPP and societal perspectives, respectively.Conclusions: Extending routine influenza vaccination to people more than 50 years of age is likely to be cost-effective in all four countries studied.
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Cross-priming of long lived protective CD8(+) T cells against Trypanosoma cruzi infection: Importance of a TLR9 agonist and CD4(+) T cells
(Elsevier B.V., 2007-08-10) Alencar, Bruna C. G. de; Araujo, Adriano F. S.; Penido, Marcus L. O.; Gazzinelli, Ricardo T.; Rodrigues, Mauricio M.; Universidade Federal de São Paulo (UNIFESP); Fiocruz MS; Universidade Federal de Minas Gerais (UFMG)
We recently described that vaccination of mice with a gluthatione S transferase fusion protein representing amino acids 261-500 of the Amastigote Surface Protein-2 efficiently cross-primed protective CD8(+) T cells against a lethal challenge with the human protozoan parasite Trypanosoma cruzi. in this study, we initially established that this protective immunity was long lived. Subsequently, we studied the importance of TLR9 agonist CpG ODN 1826, TLR4 and CD4(+) T cells for the generation of these protective CD8(+) T cells. We found that: (i) the TLR9 agonist CpG ODN 1826 improved the efficiency of protective immunity; (ii) TLR4 is not relevant for priming of specific CD8(+) T cells; (iii) CD4(+) T cells are critical for priming of memory/protective CD8(+) T cells. (c) 2007 Elsevier B.V. All rights reserved.
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Immunity After Childhood Vaccinations in Perinatally HIV-exposed Children With and Without HIV Infection in Latin America
(Lippincott Williams & Wilkins, 2018) Succi, Regina Célia de Menezes [UNIFESP]; Krauss, Margot R.; Harris, D. Robert; Machado, Daisy Maria [UNIFESP]; Moraes-Pinto, Maria Isabel de [UNIFESP]; Mussi-Pinhata, Marisa M.; Ruz, Noris Pavia; Pierre, Russell B.; Roca, Lenka A. Kolevic; Joao, Esau; Foradori, Irene; Scotta, Marcelo C.; Hazra, Rohan; Siberry, George K.
Background: Perinatally HIV-infected (PHIV) children are at risk for under-vaccination and poor vaccine response at 4 years of age. Childhood vaccine coverage and immune response were compared between PHIV and HIV-exposed uninfected (HEU) children in Latin America and the Caribbean. Methods: PHIV and HEU children were enrolled prospectively at 15 sites from 2002 to 2009. Full vaccination by age 4 years was defined as: 3 hepatitis B virus vaccine doses
Acesso aberto (Open Access)
Influenza virus surveillance among young children in São Paulo, Brazil: the impact of vaccination
(Sociedade Brasileira de Microbiologia, 2014-09-01) Cabeça, Tatiane Karen [UNIFESP]; Watanabe, Aripuanã Sakurada Aranha [UNIFESP]; Moreira, Luciana Peniche [UNIFESP]; Melchior, Thaís Boim [UNIFESP]; Perosa, Ana Helena Sitta [UNIFESP]; Camargo, Clarice Neves [UNIFESP]; Parmezan, Sheila Negrini [UNIFESP]; Bellei, Nancy Cristina Junqueira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
This study assessed the presence of influenza virus among young children and the coverage of vaccination from 2010 to 2012 in São Paulo, Brazil. Our results demonstrated a lower rate of influenza detection and a predominance of influenza B. A decrease of coverage vaccination through the surveillance periods was observed.
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Interaction between pediatric HIV infection and measles
(Future Medicine Ltd, 2011-12-01) Moraes-Pinto, Maria Isabel de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Infections by measles virus and by HIV cause a state of immunodeficiency in the host. While measles virus leads to a transient immunodeficiency with depression of cellular mediated immunity, natural HIV infection leads to a progressive immunodeficiency of both humoral and cellular immunity. This review will focus on the interaction between HIV and measles virus in pediatric patients. Different scenarios of virus interaction will be dissected and their implications for a practical approach in terms of the individual patient and strategies to eliminate measles virus will be discussed.
Acesso aberto (Open Access)
Knowledge and attitudes of health care workers from intensive care units regarding nosocomial transmission of influenza: a study on the immediate pre-pandemic period
(Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, 2011-01-01) Fortaleza, Cristiane Ravagnani [UNIFESP]; Fortaleza, Carlos Magno Castelo Branco; Universidade Federal de São Paulo (UNIFESP); Universidade Estadual Paulista (UNESP)
The transmission of influenza in health care settings is a major threat to patients, especially those with severe diseases. The attitude of health care workers (HCWs) may influence the transmission of countless infections. The current study aimed to quantify knowledge and identify attitudes of HCWs involved in intensive care units (ICUs) regarding the risk of nosocomial influenza transmission. A questionnaire was applied through interviews to HCWs who worked in one of the five ICUs from a teaching hospital. Questions about influenza were deliberately dispersed among others that assessed several infectious agents. Forty-two HCWs were interviewed: nine physicians, ten nurses and 23 nursing technicians or auxiliaries. Among the 42 HCWs, 98% were aware of the potential transmission of influenza virus in the ICUs, but only 31% would indicate droplet precautions for patients with suspected infection. Moreover, only 31% of them had been vaccinated against influenza in the last campaign (2008). Nursing technicians or auxiliaries were more likely to have been vaccinated, both by univariate and multivariable analysis. When asked about absenteeism, only 10% of the study subjects stated that they would not go to work if they had an influenza-like illness. Those findings suggest that, in non-pandemic periods, influenza control in hospitals requires strategies that combine continuous education with changes in organizational culture.
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Polysaccaride pneumococcal antibodies - Placental transfer in normal infants and in patients with Down's syndrome and ataxia telangiectasia
(Hogrefe & Huber Publishers, 2007-09-01) Costa-Carvalho, Beatriz Tavares; Universidade Federal de São Paulo (UNIFESP)
Background: Streptococcus pneumoniae is the most common cause of respiratory tract infections such as acute otitis media (AOM), sinusitis, and pneumonia in children. in addition, it is the leading cause of serious community-acquired infections including bacteremia and meningitis. the most effective strategy used to reduce the burden of disease caused by S. pneumoniae is vaccination. in the first months of life, maternal antibodies transferred by the placenta provide protection against some extracellular bacteria, but this protection can be reduced in infants born prematurely or of mothers with compromised immune defenses.Methods/Data base: A review of the literature, focusing on pneumococcal antibodies in cord blood and in two immunodeficiency groups: Ataxia telangiectasia (AT) and Down's syndrome (DS), also examining the effects of vaccination.Results/Conclusions: Infections by Streptococcus pneumoniae still remain a challenge to be solved, particularly in infants and in patients with immunologic disorders. Vaccination effects are reduced in Down syndrome and Ataxia-telangiectasia patients but perhaps the small quantity of antibodies produced can have some benefits for these patients.
Acesso aberto (Open Access)
Prática de vacinação em crianças com doenças reumáticas
(Sociedade Brasileira de Reumatologia, 2010-08-01) Silva, Clovis Artur Almeida da; Terreri, Maria Teresa Ramos Ascensão [UNIFESP]; Aikawa, Nadia Emi; Carvalho, Jozélio Freire de; Pileggi, Gecilmara Cristina Salviato; Ferriani, Virginia Paes Leme [UNIFESP]; Barbosa, Cassia Maria Passarelli Lupoli [UNIFESP]; Hilário, Maria Odete Esteves [UNIFESP]; Jesus, Adriana A; Sallum, Adriana Maluf Elias; Lotito, Ana Paola Navarrette; Liphaus, Bernadete de Lourdes; Magalhães, Claudia S; Len, Claudio Arnaldo [UNIFESP]; Okuda, Eunice Mitiko; Campos, Lucia Maria M; Carvalho, Luciana M; Ronchezel, Marcos Vinícius; Santos, Maria Carolina dos; Romanelli, Paulo Roberto Stocco; Marini, Roberto; Pereira, Rosa Maria Rodrigues; Sacchetti, Silvana Brasilia; Lotufo, Simone; Bastos, Wanda A; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Universidade Estadual Paulista (UNESP); Santa Casa de Misericórdia de São Paulo; Hospital Municipal Infantil Menino Jesus; Universidade Estadual de Campinas (UNICAMP)
INTRODUCTION/OBJECTIVES: Evaluate clinical practice through assessment of vaccination card and recommendation of specific vaccines in pediatric patients with rheumatic diseases in use of different drugs and reveal the possible association between vaccination frequency and time of the clinical practice of pediatric rheumatologists in the state of São Paulo. MATERIAL AND METHODS: A questionnaire was sent to pediatric rheumatologists of the Departamento de Reumatologia da Sociedade de Pediatria de São Paulo. This instrument included questions about practice time on Pediatric Rheumatology, vaccination of patients with juvenile systemic lupus erythematosus (JSLE), juvenile idiopathic arthritis (JIA), juvenile dermatomyositis (JDM), and immunization according to the treatments used. RESULTS: Vaccination card was seen by 100% of the professionals at the first visit and by 36% annually. Vaccines of live agents were not recommended for patients with JSLE, JIA, and JDM in 44%, 64%, and 48%, respectively. The professionals were divided into two groups: Group A (< 15 years of practice, n = 12) and B (> 16 years, n = 13). No statistical difference was observed in the use of live agent vaccine and vaccines with inactivated agents or protein components in the two treatment groups (P > 0.05). Moreover, the groups had similar opinion regarding severity of immunosuppression in patients with JSLE, JIA, and JDM (with or without activity) and treatment used (P > 0.05). CONCLUSIONS: The frequency of immunization by pediatric rheumatologists in São Paulo is low, especially after the first visit, and not influenced by time of professional practice.
Acesso aberto (Open Access)
A public health risk assessment for yellow fever vaccination: a model exemplified by an outbreak in the state of São Paulo, Brazil
(Fundaco Oswaldo Cruz, 2015-04-01) Ribeiro, Ana Freitas; Tengan, Cilea; Sato, Helena Keico; Spinola, Roberta; Mascheretti, Melissa; Costa Franca, Ana Cecilia; Port-Carvalho, Marcio; Pereira, Mariza; Souza, Renato Pereira de; Amaku, Marcos; Burattini, Marcelo Nascimento [UNIFESP]; Bezerra Coutinho, Francisco Antonio; Lopez, Luis Fernandez; Massad, Eduardo; Ctr Vigilancia Epidemiol; Inst Florestal; Superintendencia Controle Endemias Estado Sao Paul; Adolfo Lutz Inst; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Florida Int Univ; London Sch Hyg & Trop Med
We propose a method to analyse the 2009 outbreak in the region of Botucatu in the state of São Paulo (SP), Brazil, when 28 yellow fever (YF) cases were confirmed, including 11 deaths. At the time of the outbreak, the Secretary of Health of the State of São Paulo vaccinated one million people, causing the death of five individuals, an unprecedented number of YF vaccine-induced fatalities. We apply a mathematical model described previously to optimise the proportion of people who should be vaccinated to minimise the total number of deaths. the model was used to calculate the optimum proportion that should be vaccinated in the remaining, vaccine-free regions of SP, considering the risk of vaccine-induced fatalities and the risk of YF outbreaks in these regions.
Acesso aberto (Open Access)
Risk factors for poor immune response to influenza vaccination in elderly people
(Brazilian Society of Infectious Diseases, 2006-08-01) Bellei, Nancy Cristina Junqueira [UNIFESP]; Carraro, Emerson [UNIFESP]; Castelo Filho, Adauto [UNIFESP]; Granato, Celso Francisco Hernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Influenza vaccination of elderly people is efficacious and cost effective for the prevention of influenza and its complications. Some studies have pointed out low immunogenicity in this group. Health status has been poorly investigated as a risk factor that may influence the immune response to influenza vaccine. We established an immunization response study of a highly-matched elderly population in a nursing home. One-hundred-twenty subjects of Ashkenazian origin had their vaccine-induced antibody response assessed. Good response was obtained in 30.8% (37/120), and 31.7% (38/120) did not react. A lack of good response was found to be associated with dementia (P=0.016) in a multivariate analysis. In addition to dementia, malnutrition was frequently observed among poor responders, suggesting that these factors should be considered in vaccination studies. Chemoprophylaxis in addition to vaccination for elderly presenting dementia should be considered, particularly for those people living nursing homes.
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Undervaccination of Perinatally HIV-infected and HIV-exposed Uninfected Children in Latin America and the Caribbean
(Lippincott Williams & Wilkins, 2013-08-01) Succi, Regina C. M. [UNIFESP]; Krauss, Margot R.; Harris, D. Robert; Machado, Daisy M. [UNIFESP]; Moraes-Pinto, Maria Isabel de [UNIFESP]; Mussi-Pinhata, Marisa M.; Pavia Ruz, Noris; Pierre, Russell B.; Kolevic, Lenka; Joao, Esau; Foradori, Irene; Hazra, Rohan; Siberry, George K.; NISDI Pediat Study Grp 2012; Universidade Federal de São Paulo (UNIFESP); Westat Corp; Universidade de São Paulo (USP); Hosp Infantil Mexico Dr Federico Gomez; Univ W Indies; Natl Univ San Marcos Lima; Hosp Fed Servidores Estado; Univ Buenos Aires; Eunice Kennedy Shriver Natl Inst Child Hlth & Hum
Background: Perinatally HIV-infected (PHIV) children may be at risk of undervaccination. Vaccination coverage rates among PHIV and HIV-exposed uninfected (HEU) children in Latin America and the Caribbean were compared.Methods: All PHIV and HEU children born from 2002 to 2007 who were enrolled in a multisite observational study conducted in Latin America and the Caribbean were included in this analysis. Children were classified as up to date if they had received the recommended number of doses of each vaccine at the appropriate intervals by 12 and 24 months of age. Fisher's exact test was used to analyze the data. Covariates potentially associated with a child's HIV status were considered in multivariable logistic regression modeling.Results: of 1156 eligible children, 768 (66.4%) were HEU and 388 (33.6%) were PHIV. HEU children were significantly (P < 0.01) more likely to be up to date by 12 and 24 months of age for all vaccines examined. Statistically significant differences persisted when the analyses were limited to children enrolled before 12 months of age. Controlling for birth weight, sex, primary caregiver education and any use of tobacco, alcohol or illegal drugs during pregnancy did not contribute significantly to the logistic regression models.Conclusions: PHIV children were significantly less likely than HEU children to be up to date for their childhood vaccinations at 12 and 24 months of age, even when limited to children enrolled before 12 months of age. Strategies to increase vaccination rates in PHIV are needed.
Acesso aberto (Open Access)
Vacinação em pacientes imunossuprimidos e com doenças reumatológicas auto-imunes
(Sociedade Brasileira de Reumatologia, 2007-04-01) Luz, Karine Rodrigues Da [UNIFESP]; Souza, Deborah Colucci Cavalcante De [UNIFESP]; Ciconelli, Rozana Mesquita [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Vaccination is a way to prevent infectious diseases. Infections are more prevalent among patients with rheumatic diseases when compared to the general population. This higher prevalence may be due to an immune system deficiency associated with the underlying condition or to the use of immunessupressive therapy. Vaccination is an effective measure to reduce morbidy and mortality in these patients. The aim of this article is to review safety and efficacy issues concerning different vaccines for immunocompromised patients and patients with autoimmune rheumatic diseases. In general, vaccines with killed bacteria or virus are safe for patients with autoimmune rheumatic diseases, even when they are taking immunessupressive therapy. The vaccination is effective to most patients because they usually accomplish an effective immune response. Administration of attenuated vaccines with live bacteria or virus to immunocompromised patients is contraindicated.

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