Navegando por Palavras-chave "thyroid"
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- ItemSomente MetadadadosClinic-cytologic study of conjunctivochalasis and its relation to thyroid autoimmune diseases - Prospective cohort study(Lippincott Williams & Wilkins, 2006-08-01) Fiorentini de Almeida, Sandra Flavia; Sousa, Luciene B. de; Vieira, Luis A.; Chiamollera, Maria I.; Barros, Jeison de N.; Universidade Federal de São Paulo (UNIFESP)Purpose: To determine the prevalence of conjunctivochalasis in patients with immune thyroid diseases, to determine whether there is any association between the 2 diseases, and to determine cytologic study of conjunctivochalasis through the cytology impression test.Methods: A clinical prospective cohort study carried out by the External Diseases Department in the Ophthalmology Sector and the Thyroid Department in the Endocrinology Sector at Federal University of São Paulo (UNIFESP). the patients included were divided into 2 groups following these inclusion criteria: a control group of 25 patients without thyroid diseases, confirmed after clinical and laboratory examinations (thyroid hormones), or any other ocular diseases. the study group consisted of 31 patients with thyroid diseases, the diagnosis of which was confirmed by the Endocrinology Sector. the thyroidopathies included were autoimmune diseases but excluded nonautoimmune diseases. A protocol endorsed by the UNIFESP was followed, using clinical and ophthalmological history, biomicroscopy, and impression cytology.Results: Fifty-two percent of patients without thyroid diseases and 88% of patients with thyroid diseases presented with conjunctivochalasis. the risk ratio was 1.705 (Pr>chi(2)=0.0038), indicating that there is an association between them. for the impression cytology in inferior bulbar conjunctiva, there was an association between the result of the impression cytology and conjunctivochalasis (Pearson chi(2)=10.1190 Pr=0.006).Conclusion: the prevalence of conjunctivochalasis in patients with autoimmune thyroid diseases was 88%. Patients with autoimmune thyroidopathy presented higher percentages of conjunctivochalasis than the control group, confirming the association between them. the cytologic study showed the highest prevalence of abnormal surface features in eyes with conjunctivochalasis.
- ItemAcesso aberto (Open Access)Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells(Associação Brasileira de Divulgação Científica, 2001-02-01) Furlanetto, Tania Weber [UNIFESP]; Nunes Jr., R.b.; Sopelsa, A.m.i.; Maciel, Rui Monteiro de Barros [UNIFESP]; Universidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto Alegre Divisão de Medicina Interna; Universidade Federal de São Paulo (UNIFESP)Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
- ItemAcesso aberto (Open Access)Paralisia de prega vocal em tireoidite subaguda(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2007-02-01) Dedivitis, Rogério Aparecido [UNIFESP]; Coelho, Leonardo Santos; Universidade Federal de São Paulo (UNIFESP); Universidade Metropolitana de Santos Faculdade de Ciências da Saúde