Navegando por Palavras-chave "thyroid lesions"

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    Inter- and intraobserver reproducibility of thyroid fine needle aspiration cytology: an analysis of discrepant cases
    (Blackwell Publishing, 2007-04-01) Gerhard, R.; Cunha Santos, G. da; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Objective: To determine the inter- and intraobserver reproducibility and analyse the discrepant cases of fine needle aspiration cytology (FNAC) of the thyroid.Methods: Cases of thyroid FNAC with a corresponding histological diagnosis were reviewed regarding the original cytological diagnoses by two observers. the final cytological diagnoses (FCD) included both concordant and consensus diagnoses. the inter- and intraobserver reproducibility and efficacy of thyroid FNAC were calculated based on the FCD.Results: A total of 97 FNAC cases with corresponding histopathological specimens were analysed. Although inter- and intraobserver disagreement in the cytological diagnoses occurred in about one-quarter of the cases analysed (24.7% and 23.7%, respectively), a substantial level of diagnostic interobserver (kappa = 0.71) and intraobserver (kappa = 0.66) reproducibility was observed. the efficacy of the method was 94.4%. Disagreement in the diagnosis was detected in 24 cases (24.7%), most of them (41.7%) for follicular lesions. Discordant cytological diagnoses between the two observers were represented by six (16.2%) of the 37 cases with an FCD of colloid nodule, five (41.7%) of the 12 cases of cellular follicular lesion, all three cases of follicular neoplasm, in two (6.3%) of the 32 cases of PTC, one (16.7%) of six cases of follicular neoplasm with a predominance of Hurthle cells and in one case of poorly differentiated neoplasia. Similarly, major disagreement in intraobserver cytological diagnoses was observed for the diagnosis of follicular lesions: 18 (78.3%) of a total of 23 discordant cases.Conclusion: As discrepancies in the cytopathological diagnosis can have repercussions in the management of patients, all cases with a cytological diagnosis of follicular lesions/neoplams should be reviewed in multidisciplinary meetings thus minimizing interobserver variability.
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    Significance of AgNOR measurement in thyroid lesions
    (Sci Printers & Publ Inc, 2006-08-01) Camargo, Roberto Souza; Shirata, Neuza Kasumi; di Loreto, Celso; Garcia, Eduardo Anselmo; Castelo, Adauto; Longatto Filho, Adhernar; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Adolfo Lutz Inst; Univ Minho
    OBJECTIVE: To evaluate the discriminating potential of AgNOR area measurement and count in thyroid tumors using static cytometry equipment.STUDY DESIGN: Slides were analyzed by a computerized system for image analysis, CAS 200 (Becton & Dickinson, U.S.A.), using the Cell Measurement computer program WAS 200, Becton & Dickinson). The argyrophilic reaction (NORs) was evaluated with a 400-fold amplification directly from the computer monitor.RESULTS: Thirty-three cases were analyzed for AgNOR staining. The cases studied included 3 goiters, 10 follicular adenomas, 6 Hurthle adenomas, 4 follicular carcinomas, 7 papillary carcinomas, and 3 Hurthle carcinomas. A total of 6,600 nuclei were evaluated. For statistical purposes, lesions were classified as benign and malignant, and both the number and the area of counted NORs showed very similar values. The NORs median among 19 benign tumors was 1.484 (SD +/- 0.265) and of 14 malignant tumors was 1.436 (SD +/- 0.414); the NORs areas were 2.6584 (SD +/- 1.0653) and 2.3643 (SD +/- 0.6320), respectively.CONCLUSION: Our results showed that AgNOR evaluation was not a significant parameter to discriminate between malignant and benign thyroid lesions.