Navegando por Palavras-chave "tardive dyskinesia"

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    Atypical antipsychotic drugs and tardive dyskinesia: relevance of D-2 receptor affinity
    (Sage Publications Ltd, 2004-03-01) Bressan, R. A.; Jones, H. M.; Pilowsky, L. S.; Universidade Federal de São Paulo (UNIFESP); Inst Psychiat
    Evidence suggests atypical antipsychotic treatment is associated with a Lower incidence of tardive dyskinesia (TD) than typical antipsychotic drugs, and is a potential antidyskinetic treatment. We present the case of a middle-aged woman never previously exposed to antipsychotic treatment who developed TD after 6 months of olanzapine monotherapy. Substitution of quetiapine for otanzapine alleviated her TD symptoms. the case demonstrates that atypical antipsychotic drugs have different effects in relation to TD. Potential psychopharmacological mechanisms explaining these differences are discussed, highlighting the importance of D-2 receptor occupancy by atypical antipsychotic drugs for TD.
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    Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats
    (Frontiers Media Sa, 2016) Peres, Fernanda Fiel [UNIFESP]; Leyin, Raquel [UNIFESP]; Suiama, Mayra Akimi [UNIFESP]; Diana, Mariana Cepollaro [UNIFESP]; Gouvea, Douglas Albuquerque [UNIFESP]; Almeida, Valeria [UNIFESP]; Santos, Camila Mauricio [UNIFESP]; Lungato, Lisandro [UNIFESP]; Zuardi, Antonio W.; Hallak, Jaime E. C.; Crippa, Jose A.; D'Almeida, Vania [UNIFESP]; Silva, Regina Helena da [UNIFESP]; Abilio, Vanessa Costhek [UNIFESP]
    Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of reserpine in rodents induces motor impairments that are accompanied by cognitive deficits, and has been applied to model both tardive dyskinesia and Parkinson's disease. The present study investigated whether CBD administration would attenuate reserpine-induced motor and cognitive impairments in rats. Male Wistar rats received four injections of CBD (0.5 or 5 mg/kg) or vehicle (days 2-5). On days 3 and 5, animals received also one injection of 1 mg/kg reserpine or vehicle. Locomotor activity, vacuous chewing movements, and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated animals' performance on the plus-maze discriminative avoidance task, for learning/memory assessment. CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion induced by reserpine. CBD (0.5 mg/kg) also ameliorated the reserpine-induced memory deficit in the discriminative avoidance task. Our data show that CBD is able to attenuate motor and cognitive impairments induced by reserpine, suggesting the use of this compound in the pharmacotherapy of Parkinson's disease and tardive dyskinesia.
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    Concomitant development of oral dyskinesia and memory deficits in reserpine-treated male and female mice
    (Elsevier B.V., 2002-05-14) Silva, R. H.; Abilio, V. C.; Torres-Leite, D.; Bergamo, M.; Chinen, C. C.; Claro, F. T.; Carvalho, R. D.; Frussa, R.; Universidade Federal de São Paulo (UNIFESP); Univ Santo Amaro
    It has been suggested that reserpine-induced oral dyskinesia in rats may provide a new animal model of tardive dyskinesia. Both cognitive deficits and gender have been associated with the development of tardive dyskinesia. the aim of the present study was to investigate the effects of reserpine administration on the development of orofacial dyskinesia and on plus-maze discriminative avoidance task (DAT-an animal model of associative learning) in male and female mice. Male and female mice received 1.0 mg/kg reserpine or saline subcutaneously on day 1. On days 3, 6 and 8, the frequency of vacuous chewing movements (VCM) was quantified. On day 6, the DAT conditioning was performed, in a modified elevated plus-maze. in one of the enclosed arms, the animals received aversive stimulation (light and noise). On day 8, a test session was performed and the time spent by the animals in each of the enclosed arms was recorded. Our results showed that reserpine-treated male and female mice presented significantly higher VCM when compared with respective control groups in all observation days. On day 6, reserpine-treated female mice presented significantly higher VCM when compared with male mice injected with this drug. the DAT test performed on day 8 showed that the time spent in the aversive arm by saline-treated mice was significantly lower than the time spent in the non-aversive arm. This difference was not observed for reserpine-treated mice. Our results demonstrate the development of reserpine-induced oral dyskinesia in both male and female mice. While this oral dyskinesia is accompanied by a cognitive deficit in both genders, female mice tended to have more severe oral dyskinesia. It is suggested that reserpine-induced oral dyskinesia may provide a quick, simple and efficient mouse model of tardive dyskinesia. (C) 2002 Elsevier Science B.V. All rights reserved.
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    Effects of baclofen on reserpine-induced vacuous chewing movements in mice
    (Elsevier B.V., 2006-02-15) Castro, JPMV; Frussa-Filho, R.; Fukushiro, D. F.; Silva, R. H.; Medrano, W. A.; Ribeiro, R. D.; Abilio, V. C.; Universidade Federal de São Paulo (UNIFESP)
    We have described that GABA mimetic drugs present the ability to inhibit the expression of reserpine-induced oral movements. in this respect, oral movements is associated with important neuropathologies. This study investigates the effects of an acute or a repeated treatment of different doses of the GABA(B) agonist baclofen, as well as withdrawal from these treatments, on the development and/or expression of reserpine-induced vacuous chewing movements (VCM). Male mice received two injections of vehicle or of 1 mg/kg reserpine separated by 48h. in the first experiment, 24 h later, animals were acutely treated with vehicle or baclofen (1, 2 or 4 mg/kg). in the second experiment, animals were treated with vehicle or baclofen (1 or 4 mg/kg) for four consecutive days receiving a concomitant injection of 1 mg/kg reserpine (or vehicle) on Days 2 and 4. Twenty-four hours later, animals received vehicle or baclofen. Thirty minutes after the last injection, they were observed for quantification of VCM and open-field general activity. the acute administration of all the doses of baclofen abolished the manifestation of reserpine-induced VCM. Repeated treatment with 1 mg/kg baclofen induced tolerance to the ability of an acute injection of this dose to reduce VCM. Treatment with baclofen (4 mg/kg) did not modify spontaneous VCM. Acute administration of the highest dose induced a decrease in general motor activity and a potentiation of the reserpine-induced decrease in general activity. These results reinforce the involvement of GABAcrgic hypofunction in the expression of oral movements and suggest that a repeated treatment with baclofen induces compensatory changes in GABAergic transmission that can attenuate its acute property to decrease VCM. (c) 2005 Elsevier Inc. All rights reserved.
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    Effects of buspirone on an animal model of tardive dyskinesia
    (Elsevier B.V., 1999-11-01) Queiroz, Claudio MT [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    1. the effects of buspirone were studied on an animal model of tardive dyskinesia, i.e., the quantification of orofacial dyskinesia in rats repeatedly treated with reserpine.2. Rats were co-treated with saline [SAL] or buspirone [BUS] (3.0 mg/kg, i.p., twice daily) and vehicle [VEH] or reserpine [RES] (0.1 mg/kg, s.c., once every other day) for 19 days. On the day 20, the animals were observed for quantification of the behavioral parameters of orofacial dyskinesia: tongue protrusion and vacuous chewing movements frequencies and duration of twitching of the facial musculature.3. Rats of the SAL+RES group exhibited a significant increase in the three behavioral parameters of orofacial dyskinesia relative to the rats of the SAL+VEH group. However, animals of the BUS+RES group showed only an increased frequency of vacuous chewing movements when compared to animals of the SAL+VEH group. in addition, the duration of the facial twitching was significantly decreased in the BUS+RES group in relation to rats of the SAL+RES group. There were no significant differences in the orofacial parameters between the BUS+VEH and the SAL+VEH groups.4. Because it was also verified that chronic buspirone treatment was able to increase apomorphine-induced yawning behavior, the possibility is raised that buspirone attenuates reserpine-induced orofacial dyskinesia through the development of dopamine autoreceptor supersensitivity.
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    Effects of monosialoganglioside on a new model of tardive dyskinesia
    (Elsevier B.V., 1997-10-01) Vital, MABF; Frussa-Filho, Roberto [UNIFESP]; Palermo Neto, J.; Universidade de São Paulo (USP); UNIV FED PARANA; Universidade Federal de São Paulo (UNIFESP)
    1- the effects of monosialoganglioside GM(1) were studied on a new model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine.2- Rats were co-treated with vehicle (VEH) or reserpine (RES) (0.1 mg/kg, sc, every other day) and saline (SAL) or GM1 (5 mg/kg, ip, every day) for 30 days and observed for tongue protrusions on days 10, 20 and 30.3- During each test day animals of the RES+SAL, group exhibited an increase in tongue protrusions relative to rats of the VEH+SAL group. However, rats of the RES+GM(1) group showed an increased frequency of tongue protrusions only on day 10, when compared to animals of the VEH+SAL group. There were no significant differences in tongue protrusion frequency between the VEH+GM(1) and the VEH+SAL groups.4- These results differ from previous studies which reported a facilitatory effect of GM1 coadministration on conventional behavioral animal models of tardive dyskinesia: the possibility is raised that GM1 attenuates the reserpine-induced increase in tongue protrusions through its protective effect on glutamate/oxidative stress neurotoxicity.
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    Effects of valproic acid on an animal model of tardive dyskinesia
    (Elsevier B.V., 2003-06-16) Peixoto, M. F.; Abilio, V. C.; Silva, R. H.; Frussa, R.; Universidade Federal de São Paulo (UNIFESP)
    GABAergic hypofunction in the basal ganglia is stated as an important mechanism underlying the pathophysiology of tardive dyskinesia. the present study investigates the effects of the GABA-mimetic drug valproic acid (VA) on the manifestation of reserpine-induced orofacial movements, an animal model of tardive dyskinesia. Male Wistar rats received two injections of control solution or of 1 mg/kg reserpine separated by 48 h. Twenty-four hours later, animals were acutely treated with 50, 100, or 200 mg/kg VA or control solution and were observed for quantification of orofacial movements and of open-field general activity. the highest dose of VA inhibited the manifestation of reserpine-induced orofacial movements but none of the VA doses modified reserpine-induced decrease in open-field general activity. These results support the potential of VA as an effective pharmacological tool in the treatment of tardive dyskinesia. (C) 2003 Elsevier Science B.V. All rights reserved.
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    The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats
    (Elsevier B.V., 2002-02-01) Calvente, Patricia RV [UNIFESP]; Araujo, Carlos CS [UNIFESP]; Bergamo, Marcelo [UNIFESP]; Abilio, Vanessa C. [UNIFESP]; D'Almeida, Vânia [UNIFESP]; Ribeiro, Rosana de A [UNIFESP]; Frussa Filho, Roberto [UNIFESP]; Dept Farmacol; Universidade Federal de São Paulo (UNIFESP)
    The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i.e., die frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 3-Nitropropionic acid (10 or 15 mg/kg ip, every other day for 17 days) potentiated the increase in tongue-protrusion frequency induced by reserpine (1 mg/kg, sc, every other day for 3 days) but did not modify reserpine-induced increase in immobility duration and decrease in locomotion frequency. These results support the notion that neurotoxic events are associated with the development of tardive dyskinesia. (C) 2001 Elsevier Science Inc. All rights reserved.
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    Monosialoganglioside (GM(1)) attenuates the behavioural effects of longterm haloperidol administration in supersensitive rats
    (Elsevier B.V., 2004-03-01) Perry, J. C.; Vital, MABF; Frussa-Filho, R.; Tufik, S.; Palermo-Neto, J.; Univ Fed Parana; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    In the present study we investigated the effects of co-administration of GM(1) (15.0 mg/kg, twice daily, for 30 days) and haloperidol (1.0 mg/kg, twice daily, for 30 days), as well as the effects of a 5-day treatment with this dose of GM(1) after withdrawal from haloperidol in rats. the animals were evaluated in the open-field test and apomorphine-induced stereotyped behaviour. the results show that GM(1) was able to attenuate dopaminergic supersensitivity evaluated by the locomotion frequency at 24 and 48 h after the withdrawal from haloperidol. On the other hand, rearing frequency was changed neither by haloperidol nor by GM(1). in haloperidol-treated rats immobility time differs from 30 min observation session in comparison with the following sessions after the withdrawal from neuroleptic. Apomorphine-induced stereotyped behaviour produced a significant increase in scores of haloperidol-withdrawn rats. GM(1) did not modify the haloperidol effects and did not change the dopamine receptor affinity to apomorphine 100 h from abrupt neuroleptic withdrawal. (C) 2003 Elsevier B.V./ECNP. All rights reserved.
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    Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats
    (Elsevier B.V., 1998-09-04) Queiroz, CMT; Piovezan, R. D.; Frussa-Filho, R.; Universidade Federal de São Paulo (UNIFESP)
    The nigrostriatal dopaminergic system seems to be involved in both reserpine-induced orofacial dyskinesia in normal rats and in the pathogenesis of hypertension in spontaneously hypertensive rats. in the present study, repeated reserpine administration (1.0 mg/kg, s.c., every other day, for 3 days) increased tongue protrusion and vacuous chewing frequencies as well as the duration of facial twitching in Wistar normotensive but not in spontaneously hypertensive rats. These results suggest that genetic hypertension and drug-induced orofacial movements may be inversely modulated by similar mechanisms in the nigrostriatal dopaminergic system. (C) 1998 Elsevier Science B.V. All rights reserved.
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    A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
    (Academia Brasileira de Neurologia - ABNEURO, 1992-09-01) Pereira, João S. [UNIFESP]; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Ferraz, Henrique B. [UNIFESP]; Andrade, Luiz A. F. De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Tardive dyskinesia (TD), a serious complications of neuroleptic chronic use, has no effective therapy yet. We performed an experiment to study the action on TD, of the calcium channel blockers (CCB) drugs, verapamil and flunarizine. We obtained the TD model in rats, administering haloperidol for a 21-day period. After this, the stereotyped movement induced by apomorphyne was rated. The CCB drugs were administered in acute (in the 28th. day) and chronic (for 8 days, after the 25th day) experiments. Acutely, verapamil increased the stereotyped behaviour, and promoted a reduction of it in the chronic experiment. The results suggest that CCB drugs should be tested in clinical trials of TD.
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    Vitamin E attenuates reserpine-induced oral dyskinesia and striatal oxidized glutathione/reduced glutathione ratio (GSSG/GSH) enhancement in rats
    (Elsevier B.V., 2003-02-01) Abilio, Vanessa C. [UNIFESP]; Araujo, Carlos CS [UNIFESP]; Bergamo, Marcelo [UNIFESP]; Calvente, Patricia RV [UNIFESP]; D'Almeida, Vania [UNIFESP]; Ribeiro, Rosana de A. [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The effects of a previous and concomitant treatment with vitamin E (VE) were studied on an animal model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats treated with reserpine (RE). VE (5, 10, 20 or 40 mg/kg administered intraperitoneally, daily, for 19 days) attenuated the increase in tongue protrusion frequency induced by RE (1 mg/kg administered subcutaneously, on Days 16 and 18, 1 h after VE), which was quantified on Day 19. in a second experiment, a similar treatment with 20 mg/kg VE attenuated RE-induced increase in the striatal ratio of oxidized/reduced glutathione (GSSG/GSH), an index of the oxidative stress process. These results support the free radical hypothesis of tardive dyskinesia. (C) 2002 Elsevier Science Inc. All rights reserved.