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- ItemAcesso aberto (Open Access)Brazilian version of airways questionnaire 20: a reproducibility study and correlations in patients with COPD(W B Saunders Co Ltd, 2005-05-01) Camelier, Aquiles Assunção [UNIFESP]; Rosa, Fernanda Warken [UNIFESP]; Jones, Paul Wyatt; Jardim, José Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ London St Georges HospThis study describes the correlations and reproducibility of AQ20, a simple health status questionnaire with 20 questions, which was designed to be useful especially in time sparing situations. A format language validation process was done, in order to validate the AQ20 before studying its reproducibility. Thirty stable COPD patients answered the final version twice within 15 days. To test the reproducibility of AQ20, the interclass correlation coefficient and Bland Altman display were used. Results were correlated with FEV1, SpO(2), BMI, Mahler BDI, and the Saint George Respiratory Questionnaire (SGRQ). Twenty-five patients (83.3%) were male, with a mean age of 68.6 years. the mean predicted FEV1 (%) was 56.8%. the interclass correlation ratio for the total score was alpha = 0.90 for the intraobserver variability and alpha = 0.93 for the interobserver variability. the correlation with total SGRQ score was 0.76, with P < 0.001. the mean application time for AQ20 was 4min and 6s, and the score calculation time, was 8s. It can be concluded that AQ20 is reproducible, with an excellent correlation with SGRQ total score, and also having the advantage of taking just a few minutes to be applied and to have its score calculated. (c) 2004 Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosDiscriminative properties and validity of a health status questionnaire in obstructive airway disease patients: the Airway Questionnaire 20(Ediciones Doyma S/l, 2007-12-01) Camelier, Aquiles; Rosa, Fernanda W.; Nascimento, Oliver A. [UNIFESP]; Ferrandes, Ana Luiza G. [UNIFESP]; Jardim, José Roberto [UNIFESP]; Universidade Federal da Bahia (UFBA); Univ Estadual Bahia; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To evaluate the discriminative properties and validity of the Airways Questionnaire 20 (AQ20) in a sample of patients with airway obstruction and to compare its properties with those of the St George's Respiratory Questionnaire (SGRQ) and the Short Form 36 (SF-36).PATIENTS and METHODS: A convenience sample of 47 subjects was recruited from among 61 consecutive patients referred to an outpatient clinic specialized in obstructive airway diseases. All subjects completed the AQ20, SGRQ, and SF-36. Other measures were the baseline dyspnea index (BDI), 6-minute walk test (6MWT) distance, spirometry, results of arterial blood gas analysis, and body mass index.RESULTS: the AQ20 showed very good correlation with the SGRQ total score (rho=0.84, P <.001) and moderate correlation with all SF-36 domains (physical capacity, rho=-0.53; physical functioning, rho=-0.61; bodily pain, rho=-0.55; general health, rho=4.59; vitality, rho=-0.55; social functioning, rho=-0.57; emotional role functioning, rho=-0.51; mental health, rho=-0.61; all P <.001). the BDI and the 6MWT distance were the best predictors of AQ20 score (r(2)=0.31) in the regression model. An area under the receiver operating characteristic curve of 0.91 (P <.001) indicated a high level of accuracy for the AQ20, using the SGRQ as the gold standard.CONCLUSION: This study shows that the AQ20 is an accurate health status questionnaire in patients with moderate-to-severe airway obstruction. It could be an alternative to longer, traditional questionnaires such as the SGRQ.
- ItemSomente MetadadadosEvaluation of Mid-upper Arm Circumference in Pre-school Children: Comparison Between NCHS/CDC-2000 and WHO-2006 References(Oxford Univ Press, 2011-06-01) Nascimento, Viviane G.; Machado, Thais Costa; Bertoli, Ciro Joao; Abreu, Luiz Carlos de; Valenti, Vitor Engrácia [UNIFESP]; Leone, Claudio; Universidade de São Paulo (USP); Univ Taubate; Fac Med ABC; Universidade Federal de São Paulo (UNIFESP)We aimed to evaluate the classification of arm circumference (AC) in pre-school children by using National Center for Health Statistics (NCHS/CDC-2000) and World Health Organization (WHO-2006) references. We evaluated 205 children: weight, height and AC were assessed and the body mass index (BMI) was calculated. the BMI values were classified into Z-scores by the WHO referential. the AC was classified into Z-cores by two references, comparing the whole-sample value and among groups (tercis) of BMI Z-score. the correlation was also evaluated between differences of AC with BMI Z-score. the WHO referential classified the AC in Z-scores greater than the NCHS/CDC, which is more specific and less sensitive than the NCHS/CDC for lean children and at the same time more sensitive and less specific for children with overweight. in conclusion, a significant difference in the AC classification occurs according to the referential used.
- ItemSomente MetadadadosForearm skin aging: characterization by instrumental measurements(Wiley, 2017) Carvalho, P. R. S. [UNIFESP]; Sumita, J. M. [UNIFESP]; Soares, J. L. M. [UNIFESP]; Sanudo, [UNIFESP]; Bagatin, E. [UNIFESP]BACKGROUND: The intrinsic ageing and photoaged skin present biomechanical and morphological differences, which are reflected in the appearance of roughness, superficial and deep wrinkles, atrophy, reduced elasticity, hypo-and hyperpigmentation and actinic keratosis. OBJECTIVE: To evaluate and compare the characteristics of the flexor (with a predominance of intrinsic ageing) and extensor (chronically exposed to sunlight and other environmental factors, with a predominance of photoageing) skin surfaces of the forearms. METHODS: Interventional, prospective, diagnostic study, including 23 females, aged over 60 years. The extensor and flexor faces of forearms were compared in relation to clinical parameters and non-invasive instrumental measurements, such as skin surface, elasticity, hydration as well as dermal thickness and echogenicity. RESULTS: Regarding the water content of the stratum corneum, the flexor face presented an average value higher than the extensor face. The average of measures obtained through images of high-frequency ultrasound demonstrated greater echogenicity of flexor face compared to the extensor face. The measurements of the skin surface showed significant differences between the faces. The roughness and scaliness were lower in the flexor face. Regarding the depth of wrinkles, there was no significant difference between the faces. The average of the measurements was slightly higher in the flexor face, which demonstrated that wrinkles are present in the intrinsic ageing and photoageing. The presence of elastosis and the reduction in elasticity in the clinical aspect of the photoaged face of forearms were according to the results of the non-invasive measurements. CONCLUSION: Meaningful differences in the biophysical characteristics of the extensor and flexor faces of the forearms were detected. Because the non-invasive instrumental measurements correlated with clinical findings, they may represent useful tools to assess efficacy and safety of skin ageing treatments in clinical research.
- ItemAcesso aberto (Open Access)Higher prevalence of major depressive symptoms in Brazilians aged 14 and older(Associação Brasileira de Psiquiatria - ABP, 2013-04-01) Coelho, Cassiano L.s.; Crippa, José Alexandre de Souza; Santos, Jair L.f.; Pinsky, Ilana [UNIFESP]; Zaleski, Marcos [UNIFESP]; Caetano, Raul; Laranjeira, Ronaldo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); National Science and Technology Institute for Translational Medicine (INCT-TM); Universidade Federal de Santa Catarina (UFSC) Department of Psychiatry; University of Texas School of Public Health Dallas Regional CampusObjective: Depression is a highly prevalent condition and is considered a major public health issue. The aim of the present study was to estimate the prevalence of depressive symptoms in the Brazilian population and establish their sociodemographic correlates. Method: A cross-sectional study was conducted between November 2005 and April 2006. Data were collected in face-to-face interviews using a standardized questionnaire. The sample consisted of 3,007 interviews with individuals aged 14 years and older and followed a probabilistic design covering the Brazilian national territory. Depressive symptoms were assessed according to the Center for Epidemiologic Studies Depression Scale. Results: The observed prevalence of depressive symptoms was 28.3% (13% mild/moderate; 15.3% major/severe; p < 0.01). Increased depressive symptom rates were associated with being a female, being 45 years of age and older, having lower educational attainment, being single, having family income of up to 2.5 times minimum wage, and living in the northern region of Brazil (p < 0.05). Conclusions: The prevalence of depressive symptoms in Brazil is high, with major depressive symptoms being the most frequent form of this symptomatology. Considering the biopsychosocial model of mental disorders, this survey points to the involvement of psychosocial factors in the prevalence of depressive symptoms in Brazil.
- ItemSomente MetadadadosLong-wave infrared radiation reflected by compression stockings in the treatment of cellulite: a clinical double-blind, randomized and controlled study(Wiley-Blackwell, 2013-10-01) Bagatin, Edileia [UNIFESP]; Miot, H. A.; Soares, J. L. M. [UNIFESP]; Sanudo, A. [UNIFESP]; Afonso, J. P. J. M. [UNIFESP]; Barros Junior, N. de [UNIFESP]; Talarico, S. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)SynopsisBackgroundCellulite refers to changes in skin relief on the thighs and buttocks of women, with a prevalence of 80-90%, causing dissatisfaction and search for treatment. Etiopathogenesis is multifactorial, as follows: herniation of the hypodermis towards the dermis, facilitated by perpendicular fibrous septa, changes in the dermal extracellular matrix, decreased adiponectin, genetic polymorphism, microcirculation alterations and inflammatory process. There are numerous therapeutic approaches, with little evidence of effectiveness. the long-wave infrared (LWIR) radiation interacts with water, improves microcirculation and stimulates metabolic processes. To date, the use of tissues with potential reflection of LWIR radiation has not been systematically investigated as adjuvant treatment for cellulite.ObjectiveTo investigate the efficacy and safety of the treatment of cellulite through the use of compression stockings made with thread reflecting LWIR radiation.Patients and methodsClinical study of therapeutic intervention, controlled and double-blind, including 30 women, aging from 25 to 40years, with cellulite of grades II and III on the thighs and buttocks who used compression stockings, pantyhose model, made with reflector thread of LWIR radiation, on only one randomized side. Women under other treatments for cellulite and with venous and/or blood insufficiencies were excluded. Evaluation of efficacy by clinical parameters, photographs, Dermatology Life Quality Index (DLQI), cutometry and high frequency ultrasonography and security by observation of adverse events and venous EcoDoppler recordings.ResultsDLQI scores showed significant reduction; the two-dimensional high-frequency ultrasonography showed an insignificant increase in dermal echogenicity as well as other efficacy parameters demonstrated no or slight improvement, with no differences between the sides exposed or not to LWIR; and there were no severe adverse events.ConclusionCompression stockings, with or without thread reflector of LWIR, showed slight effects in the appearance of cellulite, but the treatment determined a positive impact on women quality of life.
- ItemAcesso aberto (Open Access)PCA statistical method for classification of sensors(Universidade Federal de São Paulo, 2022-11-25) Paula, Jessica Fernandes de [UNIFESP]; Antonelli, Eduardo [UNIFESP]; http://lattes.cnpq.br/8535325155568005; http://lattes.cnpq.br/9339565565705439A large number of the global population suffers from infectious diseases, so studies in the health area aimed at identifying these diseases are of great importance. Some diseases have a long immunological window, where antibodies take a long time to be identified. Rapid detection tests are essential for disease control and eradication. A possible identification and classification method uses the statistical analysis performed by the Principal Component Analysis (PCA), through which we can reduce the number of variables and identify the presence of these antibodies. This work aims to classify immunosensors according to the antibody detected, analyzing their responses in relation to impedance and frequency using the PCA statistical method. The study was based on data collected from two immunosensors, HCV sensor and HIV sensor (Hepatitis C virus and Human Immunodeficiency Virus), analyzing their response as a function of frequency. For the PCA statistical method, an interactive laboratory was adopted with Jupyter Notebook, Python, using libraries known as Pandas, Plotly, NumPyand Scikit-learn. This study analyzed several data and variables from the dataset of both sensors to build models with the PCA statistical method, it was possible to separate and classify the HIV and HCV sensors at specific frequencies. The PCA analysis results for the selected datasets showed a relevant classification using PC1 and PC2, with a variance of the original data above 90%.
- ItemSomente MetadadadosReliable assessment of forearm photoageing by high-frequency ultrasound: a cross-sectional study(Wiley-Blackwell, 2016) Caetano, L. de V. N. [UNIFESP]; Soares, J. L. M. [UNIFESP]; Bagatin, Edileia [UNIFESP]; Miot, H. A.OBJECTIVE: High-frequency ultrasound is a non-invasive tool used in skin ageing research to assess dermis thickness and echogenicity. This study evaluated the reliability of a range of high-frequency ultrasound parameters and tested their correlation with age and a validated clinical scale for the assessment of forearm skin photoageing
- ItemSomente MetadadadosA validated model for the 22-item Sino-Nasal Outcome Test subdomain structure in chronic rhinosinusitis(Wiley, 2017) Feng, Allen L.; Wesely, Nicholas C.; Hoehle, Lloyd P.; Phillips, Katie M.; Yamasaki, Alisa; Campbell, Adam P.; Gregorio, Luciano L. [UNIFESP]; Killeen, Thomas E.; Caradonna, David S.; Meier, Josh C.; Gray, Stacey T.; Sedaghat, Ahmad R.BackgroundPrevious studies have identified subdomains of the 22-item Sino-Nasal Outcome Test (SNOT-22), reflecting distinct and largely independent categories of chronic rhinosinusitis (CRS) symptoms. However, no study has validated the subdomain structure of the SNOT-22. This study aims to validate the existence of underlying symptom subdomains of the SNOT-22 using confirmatory factor analysis (CFA) and to develop a subdomain model that practitioners and researchers can use to describe CRS symptomatology. MethodsA total of 800 patients with CRS were included into this cross-sectional study (400 CRS patients from Boston, MA, and 400 CRS patients from Reno, NV). Their SNOT-22 responses were analyzed using exploratory factor analysis (EFA) to determine the number of symptom subdomains. A CFA was performed to develop a validated measurement model for the underlying SNOT-22 subdomains along with various tests of validity and goodness of fit. ResultsEFA demonstrated 4 distinct factors reflecting: sleep, nasal, otologic/facial pain, and emotional symptoms (Cronbach's alpha, >0.7; Bartlett's test of sphericity, p < 0.001; Kaiser-Meyer-Olkin >0.90), independent of geographic locale. The corresponding CFA measurement model demonstrated excellent measures of fit (root mean square error of approximation, <0.06; standardized root mean square residual, <0.08; comparative fit index, >0.95; Tucker-Lewis index, >0.95) and measures of construct validity (heterotrait-monotrait [HTMT] ratio, <0.85; composite reliability, >0.7), again independent of geographic locale. ConclusionThe use of the 4-subdomain structure for SNOT-22 (reflecting sleep, nasal, otologic/facial pain, and emotional symptoms of CRS) was validated as the most appropriate to calculate SNOT-22 subdomain scores for patients from different geographic regions using CFA.