Navegando por Palavras-chave "spectral-domain optical coherence tomography"
Agora exibindo 1 - 4 de 4
Resultados por página
Opções de Ordenação
- ItemSomente MetadadadosHYPERAUTOFLUORESCENT RING in AUTOIMMUNE RETINOPATHY(Lippincott Williams & Wilkins, 2012-07-01) Lima, Luiz H. [UNIFESP]; Greenberg, Jonathan P.; Greenstein, Vivienne C.; Smith, R. Theodore; Sallum, Juliana M. F. [UNIFESP]; Thirkill, Charles; Yannuzzi, Lawrence A.; Tsang, Stephen H.; Columbia Univ; Vitreous Retina Macula Consultants New York; Manhattan Eye Ear & Throat Hosp; Universidade Federal de São Paulo (UNIFESP); Univ Calif DavisPurpose: To report the presence of a hyperautofluorescent ring and corresponding spectral-domain optical coherence tomography (SD-OCT) features seen in patients with autoimmune retinopathy.Methods: All eyes were evaluated by funduscopic examination, full-field electroretinography, fundus autofluorescence, and SD-OCT. Further confirmation of the diagnosis was obtained with immunoblot and immunohistochemistry testing of the patient's serum. Humphrey visual fields and microperimetry were also performed.Results: Funduscopic examination showed atrophic retinal pigment epithelium (RPE) associated with retinal artery narrowing but without pigment deposits. the scotopic and photopic full-field electroretinograms were nondetectable in three patients and showed a cone-rod pattern of dysfunction in one patient. Fundus autofluorescence revealed a hyperautofluorescent ring in the parafoveal region, and the corresponding SD-OCT demonstrated loss of the photoreceptor inner segment-outer segment junction with thinning of the outer nuclear layer from the region of the hyperautofluorescent ring toward the retinal periphery. the retinal layers were generally intact within the hyperautofluorescent ring, although the inner segment-outer segment junction was disrupted, and the outer nuclear layer and photoreceptor outer segment layer were thinned.Conclusion: This case series revealed the structure of the hyperautofluorescent ring in autoimmune retinopathy using SD-OCT. Fundus autofluorescence and SD-OCT may aid in the diagnosis of autoimmune retinopathy and may serve as a tool to monitor its progression. RETINA 32:1385-1394, 2012
- ItemSomente MetadadadosIdentification of the Most Accurate Spectral-domain Optical Coherence Tomography Parameters in Eyes With Early High-Tension and Low-Tension Glaucoma(Lippincott Williams & Wilkins, 2016) Gracitelli, Carolina Pelegrini Barbosa [UNIFESP]; Moreno, Pilar de Andrade Memoria [UNIFESP]; Leite, Mauro Toledo [UNIFESP]; Prata, Tiago dos Santos [UNIFESP]Purpose: The aim of the study was to compare the diagnostic ability of macular ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) thickness in high-tension glaucoma (HTG) and low-tension glaucoma (LTG). Patients and Methods: Glaucoma was defined as glaucomatous optic neuropathy and reproducible visual field defects. Patients were classified as having LTG if untreated intraocular pressure was <= 21mm Hg on 2 different occasions. Only eyes with early glaucoma (mean deviation < -6 dB) were included. All patients underwent spectral-domain optical coherence tomography (SDOCT) imaging. Results: A total of 56 normal subjects, 64 HTG patients, and 35 LTG patients were enrolled. Overall, after adjusting for mean deviation and age, the average pRNFL thickness in eyes with LTG was 18.7 mm thinner than in eyes with HTG (17% difference, P < 0.01). In the HTG group, no significant difference was found between areas under the receiver operating characteristic curve (AUCs) for average GCC and average pRNFL thicknesses (0.77 vs. 0.68, P = 0.06). In the LTG group, average pRNFL thickness had a significantly larger AUC compared with average GCC thickness (0.95 vs. 0.81, P < 0.001). Comparing AUCs between HTG and LTG groups, although the average GCC had similar AUCs in both groups (P = 0.47), the average pRNFL thickness had a significantly larger AUC in the LTG group (P < 0.001). Conclusions: In eyes with early glaucoma, the pRNFL thickness scan seems to be a more accurate SDOCT protocol to identify those with LTG compared with the GCC thickness scan.
- ItemSomente MetadadadosSpectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments(Lippincott Williams & Wilkins, 2013-09-01) Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]; Yehoshua, Zohar; Gregori, Giovanni; Farah, Michel Eid [UNIFESP]; Feuer, William; Rosenfeld, Philip J.; Univ Miami; Universidade Federal de São Paulo (UNIFESP)Purpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging.Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used to quantify volumetric changes in DPEDs and to detect the evolution and formation of geographic atrophy and choroidal neovascularization. Changes in DPED area and volume and development of the advanced forms of AMD were the main outcome.Results: Of the 130 patients (186 eyes) with nonadvanced AMD, 11 patients (16 eyes) presented with DPEDs during the study. Mean follow-up was 18.5 months. Most DPEDs had an area exceeding 1 disk area (14 of 16 eyes) based on color fundus images with a mean area of 4.19 mm(2) (SD = 1.35) measured by spectral-domain optical coherence tomography. The mean volume at the time the DPED was diagnosed was 0.48 mm(3) (SD = 0.28). Four different patterns of progression were observed: DPEDs remained unchanged in 8 of 16 eyes (50%), DPEDs tended to increase in volume before progressing to geographic atrophy in 5 eyes (31.25%) and choroidal neovascularization in 2 eyes (12.5%), and a DPED decreased by more than 50% without progressing to geographic atrophy or choroidal neovascularization in 1 eye (6.25%).Conclusion: Spectral-domain optical coherence tomography imaging is able to detect subtle changes in the area and volume of DPEDs. Quantitative spectral-domain optical coherence tomography imaging of DPEDs is useful for identifying the natural history of disease progression and as a clinical tool for monitoring eyes with AMD in clinical trials.
- ItemSomente MetadadadosSPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY in PATIENTS WITH COMMOTIO RETINAE(Lippincott Williams & Wilkins, 2012-04-01) Souza-Santos, Franklin [UNIFESP]; Lavinsky, Daniel [UNIFESP]; Moraes, Nilva S. [UNIFESP]; Castro, Andre R. [UNIFESP]; Cardillo, Jose A.; Farah, Michel E. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hosp Olhos AraraquaraPurpose: To describe the morphologic characteristics of commotio retinae using spectral-domain optical coherence tomography and to evaluate its utility in prognosis and follow-up.Methods: Consecutive patients with commotio retinae underwent complete ophthalmic examination, color fundus photography, spectral-domain optical coherence tomography, fundus autofluorescence, and near-infrared autofluorescence.Results: There were 11 eyes of 11 patients (8 men), with a mean age of 30.8 +/- 12.1 years. the follow-up ranged from 9 days to 6 months. Spectral-domain optical coherence tomography identified hyperreflectivity underneath the inner/outer segment junction in the area of commotio retinae in 9 patients (81.1%), which subsided in a few days. Five patients (45.5%) revealed areas of disruption of the inner/outer segment junction and hyperreflectivity of the overlying retina, which progressed to external retinal atrophy and visual loss (P = 0.002). the 5 patients with visual sequelae revealed pigment disorders and alterations in fundus autofluorescence and near-infrared autofluorescence during follow-up, and 3 patients (60%) presented with intraretinal hemorrhages.Conclusion: Spectral-domain optical coherence tomography of mild lesions with good visual outcome showed transient hyperreflectivity of the outer retina. the cases with severe trauma were related to acute disruption of the inner/outer segment junction and hyperreflectivity of the overlying retina and were regularly associated with retinal atrophy, pigment disturbance, and poor visual prognosis. RETINA 32: 711-718, 2012