Navegando por Palavras-chave "sleep-wake cycle"

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    The amount of diurnal sleep, and complaints of fatigue and poor sleep, in night-working women: the effects of having children
    (Swets Zeitlinger Publishers, 2000-01-01) Rotenberg, L.; Moreno, C. [UNIFESP]; Portela, L. F.; Benedito-Silva, A. A.; Menna-Barreto, L.; FIOCRUZ; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    This study deals with female industrial night workers. There is little scientific literature on this topic since, until recently, such shift systems have in most countries been restricted to men. the amount of diurnal sleep, as well as complaints about fatigue and poor sleep, were compared in women who were (n = 17) or were not (n = 26) caring for children. the women were engaged at an assembly line, working nights (22:00-06:00) from Monday to Friday. They filled out sleep logs for 10 consecutive weeks and were interviewed about complaints concerned with fatigue and poor sleep. A comparison of the diurnal sleeps taken between consecutive night shifts showed that the average total length of daily sleep, as well as the time of onset of the first sleep, did not differ between the groups; however, workers who had children tended to show, in comparison with their childless colleagues, more sleep episodes per day and a shorter first sleep. the total number of complaints about poor sleep and fatigue did not differ between the groups; nevertheless, workers with children complained more of difficulty in falling asleep, had a greater dissatisfaction with the amount of sleep on weekdays, and tended to show an increasing fatigue as the week progressed. We conclude that there are social pressures in women who care for children that are in addition to those that are a general consequence of night work. These results reinforce a need for the implementation of measures that organise child care, so helping a mother who wishes to work also outside the home.
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    Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats
    (Sage Publications Ltd, 2013-03-01) Chagas, Marcos Hortes N.; Crippa, Jose Alexandre S.; Zuardi, Antonio Waldo; Hallak, Jaime E. C.; Machado-de-Sousa, Joao Paulo; Hirotsu, Camila [UNIFESP]; Maia, Lucas [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle.Objective: the objective of this paper is to assess the effects on sleep of acute systemic administration of CBD.Method: Adult male Wistar rats were randomly distributed into four groups that received intraperitoneal injections of CBD 2.5 mg/kg, CBD 10 mg/kg, CBD 40 mg/kg or vehicle (n=seven animals/group). Sleep recordings were made during light and dark periods for four days: two days of baseline recording, one day of drug administration (test), and one day after drug (post-test).Results: During the light period of the test day, the total percentage of sleep significantly increased in the groups treated with 10 and 40 mg/kg of CBD compared to placebo. REM sleep latency increased in the group injected with CBD 40 mg/kg and was significantly decreased with the dose of 10 mg/kg on the post-test day. There was an increase in the time of SWS in the group treated with CBD 40 mg/kg, although this result did not reach statistical significance.Conclusion: the systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration.
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    Sleep/wake cycle parameters and sleep/fatigue complaints in female night workers
    (Swets Zeitlinger Publishers, 1998-12-01) Rotenberg, L.; Moreno, C.; Benedito-Silva, A. A.; Menna-Barreto, L.; FIOCRUZ; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Adaptation to shift-work is influenced by the way workers schedule their lives, including allocation of sleep episodes. Female workers (n = 29) engaged at an assembly line were studied as to individual differences in sleep parameters in order to verify whether those differences could be related to the manifestation of sleep and fatigue complaints. the sample was composed of women (20-40 y) working at night from Monday to Friday. Sleep data were based on daily sleep logs which were filled out by the workers for 10 consecutive weeks. in the analyses of sleep data both diurnal episodes between consecutive night shifts and noctural sleep episodes preceding working nights were taken into account. Worker's complaints were analyzed through questions extracted from an interview form encompassing questions on fatigue associated with the work schedule and on dissatisfaction with sleep on weekdays and weekends. the analysis of diurnal episodes showed no significant correlation between the total amount of sleep per day and the total number of complaints. Nevertheless, the latter was correlated to the length of the first sleep episode on a day, which usually began in the morning. As to sleep onset times, significant correlations were not detected concerning the first diurnal episodes. the analysis of nocturnal episodes did not reveal any significant correlation between sleep parameters and complaints. Results indicate that workers whose sleep onsets were allocated to the morning and were able to sleep for many consecutive hours, tended to show less complaints, suggesting that the temporal allocation of diurnal sleep and its length are relevant in the determination of how these workers perceive fatigue and sleep quality.
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    Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery
    (Amer Physiological Soc, 2012-11-01) Pellegrino, R. [UNIFESP]; Sunaga, D. Y.; Guindalini, C. [UNIFESP]; Martins, R. C. S. [UNIFESP]; Mazzotti, D. R. [UNIFESP]; Wei, Z.; Daye, Z. J.; Andersen, M. L. [UNIFESP]; Tufik, S. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); New Jersey Inst Technol; Univ Penn
    Pellegrino R, Sunaga DY, Guindalini C, Martins RC, Mazzotti DR, Wei Z, Daye ZJ, Andersen ML, Tufik S. Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery. Physiol Genomics 44: 1003-1012, 2012. First published September 4, 2012; doi: 10.1152/physiolgenomics.00058.2012.-Although the specific functions of sleep have not been completely elucidated, the literature has suggested that sleep is essential for proper homeostasis. Sleep loss is associated with changes in behavioral, neurochemical, cellular, and metabolic function as well as impaired immune response. Using high-resolution microarrays we evaluated the gene expression profiles of healthy male volunteers who underwent 60 h of prolonged wakefulness (PW) followed by 12 h of sleep recovery (SR). Peripheral whole blood was collected at 8 am in the morning before the initiation of PW (Baseline), after the second night of PW, and one night after SR. We identified over 500 genes that were differentially expressed. Notably, these genes were related to DNA damage and repair and stress response, as well as diverse immune system responses, such as natural killer pathways including killer cell lectin-like receptors family, as well as granzymes and T-cell receptors, which play important roles in host defense. These results support the idea that sleep loss can lead to alterations in molecular processes that result in perturbation of cellular immunity, induction of inflammatory responses, and homeostatic imbalance. Moreover, expression of multiple genes was downregulated following PW and upregulated after SR compared with PW, suggesting an attempt of the body to re-establish internal homeostasis. in silico validation of alterations in the expression of CETN3, DNAJC, and CEACAM genes confirmed previous findings related to the molecular effects of sleep deprivation. Thus, the present findings confirm that the effects of sleep loss are not restricted to the brain and can occur intensely in peripheral tissues.