Navegando por Palavras-chave "seizure frequency"
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- ItemSomente MetadadadosThe course of untreated seizures in the pilocarpine model of epilepsy(Elsevier B.V., 1999-04-01) Arida, R. M.; Scorza, F. A.; Peres, CDA; Cavalheiro, E. A.; Universidade Federal de São Paulo (UNIFESP)The course of untreated epilepsy is not well. established. This study uses a model of chronic limbic epilepsy (pilocarpine model of epilepsy) to determine the pattern of occurrence of seizures in untreated animals. Following pilocarpine administration, 21 rats were monitored continuously with a video system for 135 days after the first spontaneous seizure. Animals showed a great variability in seizure numbers and were divided in two subgroups presenting either a low frequency of seizures (n = 9 animals presenting ten or less seizures in the first 15 days of observation) or a high frequency of seizures (n = 12 animals presenting more than ten seizures during this period). Animals with low number of seizures during the first 15 days of observation showed a significant increase in seizure frequency in the following period of analysis (until 105 days). On the other hand, those with initial high number of seizures showed Significant changes in seizure frequency only in the first 2 months. the duration of each spontaneous seizure did not change significantly over time. These findings show that in untreated epilepsy there is a maturation process in the early stages and this accelerating process can be of predictive value for the treatment of epilepsy. (C) 1999 Elsevier Science B.V. All rights reserved.
- ItemAcesso aberto (Open Access)Does sudden unexpected death in children with epilepsy occur more frequently in those with high seizure frequency?(Academia Brasileira de Neurologia - ABNEURO, 2009-12-01) Terra, Vera Cristina; Scorza, Fulvio Alexandre [UNIFESP]; Sakamoto, Américo Ceiki [UNIFESP]; Pinto, Kylvia Giselle Fernades Dantas; Fernandes, Regina Maria França; Arida, Ricardo Mario [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Machado, Helio Rubens; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)People with epilepsy are more likely to die prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). Several studies have reported a moderate or high seizure frequency among SUDEP cases and SUDEP is considered rare in patients in remission. METHOD: We reviewed the occurrence of SUDEP in our epilepsy unit over an 8-year period to identify a potential association between seizure frequency and SUDEP occurrence in children with epilepsy. RESULTS: From 835 patients evaluated, 12 had suffered SUDEP and nearly all of the SUDEP cases in our children are related to chronic uncontrolled epilepsy (daily - 50.0%, two to four/week - 41.7%, monthly - 8.3%). CONCLUSION: SUDEP is not a rare event in children and increased mortality was recorded in those individuals who had not responded to pharmacologic treatment. Improved seizure control seems to be one of the most important measures to prevent SUDEP.
- ItemAcesso aberto (Open Access)Tradução e adaptação cultural da Seizure Severity Questionnaire: resultados preliminares(Liga Brasileira de Epilepsia (LBE), 2006-03-01) Silva, Tatiana Indelicato da [UNIFESP]; Alonso, Neide Barreira [UNIFESP]; Azevedo, Auro Mauro [UNIFESP]; Westphal-Guitti, Ana Carolina [UNIFESP]; Migliorini, Rosa Cristina Vaz Pedroso [UNIFESP]; Marques, Carolina Mattos [UNIFESP]; Caboclo, Luís Otávio Sales Ferreira [UNIFESP]; Sakamoto, Américo Ceiki [UNIFESP]; Yacubian, Elza Márcia Targas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)INTRODUCTION: Seizure severity and seizure frequency reduction are the goals in the treatment of epilepsy. Up to the present, there are no validated instruments or studies emphasizing initial reliability and validity of questionnaires to measure seizure severity into Brazilian Portuguese. PURPOSE: This report describes the translation and cross-cultural adaptation of the Seizure Severity Questionnaire (SSQ), an instrument to evaluate seizure frequency and severity. CASUISTIC AND METHODS: The author conceded the original English version to Portuguese translation. Later, two independent native English-speaking teachers fluent in Portuguese translated this consensus version back into English. Comparison of the back-translation with the original English version showed only a few discrepancies, and the English and Portuguese versions were considered conceptually equivalent. Thirty patients regularly treated with temporal lobe epilepsy related to mesial temporal sclerosis answered the questionnaire. RESULTS: Twenty-two adult patients (73%) were male and mean age 37. Ten (33%) reported only auras and 18 Movements or attitudes during the seizures. Two presented Loss of consciousness. For 13 (43%) there was a long time to recuperate after the event. 12 reported Emotional effects and all patients had Body effects. The majority of patients, 28 (94%) considered their seizures extremely severe and for 23 (77%) the recuperation period was the most bother symptom. The association of seizure frequency and Nottingham Health Profile showed statistical significance for the domains: Emotional well-being (p = 0.046), Pain (p = 0.015) and Sleep (p = 0.003). CONCLUSION: This study explored the cultural adaptation of SSQ and its first results. We also assessed the correlation between seizure frequency and quality of life impact. The instrument SSQ could help to understand the seizure concern in the view of the patient.