Navegando por Palavras-chave "retocolite ulcerativa"

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    Anticorpo anticitoplasma de neutrófilos (ANCA) em pioderma gangrenoso, um marcador sorológico para associação com doenças sistêmicas: estudo de oito casos
    (Sociedade Brasileira de Dermatologia, 2004-02-01) Cabral, Virgínia Lúcia Ribeiro [UNIFESP]; Miszputen, Sender Jankiel [UNIFESP]; Catapani, Wilson Roberto; Universidade Federal de São Paulo (UNIFESP); Faculdade de Medicina do ABC
    BACKGROUND: The pathogenesis of Ulcerative Colitis (UC) and its extraintestinal manifestations remain uncertain, although involvement of the immune system is emphasized. The likely importance of neutrophils is demonstrated by detection of the antineutrophil cytoplasmic antibody (ANCA) in this inflammatory bowel disease. Pyoderma Gangrenosum (PG) is an idiopathic skin condition and a rare cutaneous manifestation of UC. ANCA has also been reported in the latter dermatosis. OBJECTIVES: To invetigate the relationship between clinical features of UC and the appearance of PG and its association with ANCA. PATIENTS AND METHODS: ANCA was determined in sera from eight patients with PG. Four out of eight patients had pyoderma gangrenosum associated-UC, and in four cases no identified systemic disease was associated. RESULTS: The search for ANCA yielded negative results in sera from all four patients with pyoderma not associated with systemic disease. Two cases with active and extensive colitis associated with PG and primary sclerosing cholangitis (PSC) were positive for ANCA. Sera from two other patients with both UC and PG had negative test results. CONCLUSIONS: The presence of ANCA in patients with PG associated with UC and PSC suggests that its association with PSC is responsible for ANCA positivity in this subset of patients.
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    Do standardization and quantification of histopathological criteria improve the diagnosis of inflammatory bowel disease?
    (Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2014-06-01) Baldin, Rosimeri Kuhl Svoboda; Telles, José Ederaldo Queiroz; Bonardi, Renato Araújo; Amarante, Heda Maria Barska Dos Santos; Baldin Júnior, Antônio; Universidade Federal do Paraná Hospital de Clínicas Medical Pathology Department; Universidade Federal de São Paulo (UNIFESP); UFPR Hospital de Clínicas Medical Pathology Department; UFPR Department of Surgery; UFPR Internal Medicine Department; UFPR Hospital de Clínicas
    Introduction:Inflammatory bowel disease comprises two major categories: Crohn's disease and ulcerative rectocolitis, both with different clinical and histological aspects, causing sometimes significant morbidity.Objectives:Choose and apply standardized and quantified histopathological diagnosis method, and compare the results and quality index with the original diagnosis.Materials and methods:43 histological colonoscopic biopsies of 37 patients were re-evaluated by standardized system.Results and discussion:The original diagnoses were more inconclusive (23.3%) than those standardized (2.3%). The agreement with gold standard (clinical, colonoscopical, and radiological diagnosis) was higher on standardized diagnoses (95.3%) than in original (74.4%), especially in relation to Crohn's disease, which percentages were 92.3% and 46.1%, respectively. The quality index was calculated in conclusive diagnosis of each method. For ulcerative rectocolitis, both methods showed sensitivity and negative predictive value of 100%; otherwise the original diagnosis demonstrated specificity of 85.7%, positive predictive value of 96.3% and accuracy of 97.0%, and the standardized diagnosis 92.3%, 96.7% and 97.6%, respectively. For Crohn's disease, there is specificity and positive predictive value of 100% in both methods; the original diagnosis showed sensitivity of 85.7%, negative predictive value of 96.3% and accuracy of 97%, while for the standardized diagnoses 92.3%, 96.7%, and 97.6%, respectively.Conclusion:The standardized diagnosis presented a higher percentage of correct and conclusive diagnoses than those presented in the original diagnosis, especially for Crohn's disease, as well as equal or slightly higher values in some quality index.