Navegando por Palavras-chave "progression"
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- ItemSomente MetadadadosConcomitant expression of epithelial-mesenchymal transition biomarkers in breast ductal carcinoma: Association with progression(Spandidos Publ Ltd, 2010-02-01) Logullo, Angela Flavia [UNIFESP]; Nonogaki, Suely; Pasini, Fatima Solange; Bueno de Toledo Osorio, Cynthia Aparecida; Soares, Fernando Augusto; Brentani, M. Mitzi; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Hosp AC Camargo Fund Antonio PrudenteEpithelial to mesenchymal transition (EMT) is a process implicated in cancer progression in which the underlying cellular changes have been identified mainly using in vitro models. We determined the expression of some putative EMT biomarkers including E-cadherin, beta-catenin, zinc finger factor Snail (Snail), transforming growth factor beta 1 (TGF beta 1), TGF beta type II receptor (TBRII) and the HGF receptor (c-met) and their possible correlation to progression and overall survival in a series of breast ductal carcinoma in situ (DCIS) and invasive ductal carcinomas (IDC). Biomarkers were immunohistochemically determined in 55 IDC specimens from which 21 had lymph node metastases and in 95 DCIS specimens, 46 of these cases associated to invasive carcinoma, in a tissue microarray (TMA). Positive cytoplasmic staining of TGF beta 1 (78.2%), c-met (43.6%), Snail (34.5%), TBRII (100%), membranous E-cadherin (74.5%) and membranous/cytoplasmic beta-catenin (71%) were detected in the IDC samples. Metastatic lymph node samples displayed similar frequencies. A significant increase of c-met and TGF beta 1 positivity along DCIS to IDC progression was noted but only TGF beta 1 positivity was associated with presence of lymph node metastases and advanced stages in IDC. the evaluation of the other EMT markers in DCIS did not show differences in positivity rate as compared to invasive carcinomas. DCIS either pure or associated to IDC showed similar expression of the analyzed biomarkers. All the carcinomas exhibited positive expression of TBRII. Associations between the markers, determined by Spearman's correlation coefficient, showed a significant association between TGF beta 1 and respectively E-cadherin, beta-catenin and cmet in DCIS cases, but in invasive carcinomas only cadherin and catenin were positively correlated. Kaplan-Meier survival curves revealed that none of the EMT biomarkers analyzed were correlated with survival, which was significantly determined only by clinical and hormone receptor parameters.
- ItemAcesso aberto (Open Access)Displasia broncopulmonar(Sociedade Brasileira de Pediatria, 2005-04-01) Monte, Luciana F. Velloso; Silva Filho, Luiz Vicente F. Da; Miyoshi, Milton Harumi [UNIFESP]; Rozov, Tatiana [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Hospital e Maternidade Santa Joana Unidade de Terapia Intensiva NeonatalOBJECTIVE: To present a wide-ranging review of the literature on bronchopulmonary dysplasia, covering new definitions, pathophysiology, prevention, treatment, prognosis and progression. SOURCES OF DATA: The most relevant articles published on the subject since it was first described in 1967 were selected from MEDLINE search results. SUMMARY OF THE FINDINGS: Bronchopulmonary dysplasia is considered one of the primary causes of chronic lung disease among infants. It is associated with frequent and prolonged hospital admissions, in particular for pulmonary diseases, with high rates of mortality and alterations to neuropsychomotor development and pondero-statural growth. Pathogenesis is complex, being primarily influenced by prematurity, infection, supplementary oxygen and mechanical ventilation. Prevention involves appropriate prenatal care, the prevention of premature delivery, prenatal corticosteroids, surfactant replacement therapy and protective ventilatory strategies. Treatment of bronchopulmonary dysplasia patients demands a multidisciplinary team. When indicated, oxygen supplementation is extremely important. Despite increased risk of morbidity and mortality during the first years of life, long term progress is favorable in the majority of cases. CONCLUSIONS: Bronchopulmonary dysplasia has been and continues to be studied in great depth with the objective of identifying its causes and possible prevention and treatment strategies. Controversies remain with respect of these issues and also about the prognosis of these patients, in particular when the subject is long-term progress of new bronchopulmonary dysplasia patients.
- ItemAcesso aberto (Open Access)Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration(Assoc Research Vision Ophthalmology Inc, 2017) Ferrara, Daniela; Silver, Rachel E.; Louzada, Ricardo N.; Novais, Eduardo A. [UNIFESP]; Collins, Giliann K.; Seddon, Johanna M.PURPOSE. Age-related macular degeneration (AMD) is a progressive disease with multifactorial etiology. There is a need to identify clinical features that are harbingers of advanced disease. We evaluated morphologic features of the retina and choroid on optical coherence tomography (OCT) to determine if they predict progression to advanced disease. METHODS. Progressors transitioned from early or intermediate AMD to advanced disease (n = 40 eyes), and were matched on baseline AMD grade and follow-up interval to nonprogressors who did not develop advanced AMD (n = 40 eyes). Features of the neurosensory retina, photoreceptors, retinal pigment epithelium (RPE), and choroid were evaluated. Logistic regression was used to evaluate univariate associations between features and progression to overall advanced AMD, geographic atrophy (GA), and neovascular disease (NV). Multivariate associations based on stepwise regression models were also assessed. RESULTS. Ellipsoid zone disruption was associated with progression to overall advanced AMD and NV (odds ratios [ORs]: 17.9 and 30.6
- ItemSomente MetadadadosRetinal arterial diameter changes in progressive and nonprogressive glaucoma(Lippincott Williams & Wilkins, 2003-06-01) Soares, Adael S. [UNIFESP]; Artes, P. H.; McCormick, T. A.; LeBlanc, R. P.; Nicolela, M. T.; Chauhan, B. C.; Dalhousie Univ; Universidade Federal de São Paulo (UNIFESP)Purpose: To determine if the degree of retinal arterial diameter change is different between patients with progressive and nonprogressive open-angle glaucoma.Material and Methods: in this prospective cohort study, 44 eyes of 44 open-angle glaucoma patients (mean age, 67.5 years; age range, 52-84 years; mean follow-up period, 4.9 years; follow-up range, 1.3-7.5 years) were included. the change in arterial diameter between the baseline and the most recent follow-up optic disc photograph was determined. the diameter of the 4 major arteries was measured at the optic disc margin and at the thinnest and broadest locations within 1 optic disc diameter from the disc margin. Patients were stratified into progressing and nonprogressing groups according to visual field and optic disc criteria.Results: Visual field progression was observed in 13 (30%) patients and optic disc progression in 24 (55%) patients. On average, the arterial diameters at the edge of the optic disc decreased significantly by 2.37% (95% CI, -3.31% to - 1.41%) per year of follow-up (P<0.001). No significant difference in generalized or focal arterial narrowing was observed between progressive and nonprogressive groups regardless of the criterion used (P>0.462). With this sample, the power to detect a 10% difference in arterial narrowing between the 2 groups was 66%. There was no relationship between the rates of visual field progression and arterial diameter change in the whole group (P = 0.171) or in groups segregated into progressing and nonprogressing patients (P>0.104).Conclusion: Arterial diameters decreased in both progressive and nonprogressive glaucoma. in this study, there was little evidence that arterial narrowing was more pronounced in progressive disease.
- ItemAcesso aberto (Open Access)Retrocollis, anterocollis or head tremor may predict the spreading of dystonic movements in primary cervical dystonia(Academia Brasileira de Neurologia - ABNEURO, 2009-06-01) Godeiro-Junior, Clecio [UNIFESP]; Felício, André Carvalho [UNIFESP]; Aguiar, Patrícia Maria de Carvalho [UNIFESP]; Borges, Vanderci [UNIFESP]; Silva, Sonia Maria Azevedo [UNIFESP]; Ferraz, Henrique Ballalai [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)BACKGROUND AND PURPOSE: Few studies have attempted to develop clinical predictors for cervical dystonia (CD) aiming at progression of the dystonic movement. METHOD: We retrospectively evaluated 73 patients with primary CD who underwent treatment with Botulinum toxin type-A (BTX-A). The patients were assembled in two groups according to the spread of dystonia during follow-up: spreading and non-spreading CD. We performed a binary logistic regression model using spreading of cervical dystonia as dependent variable aiming to find covariates which increase the risk of spreading. RESULTS: Our logistic regression model found the following covariates and their respective risk ratios: time of disease >18.5 months=2.4, retrocollis=1.9, anterocollis=1.8, head tremor=1.6. CONCLUSION: Time of disease >18.5 months, retrocollis, anterocollis and head tremor may predict spreading of dystonic movement to other regions of the body in CD patients.
- ItemAcesso aberto (Open Access)Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma(Wiley-Blackwell, 2011-03-01) Logullo, Angela Flavia [UNIFESP]; Agata Stiepcich, Monica Maria; Bueno de Toledo Osorio, Cintia Aparecida [UNIFESP]; Nonogaki, Sueli; Pasini, Fatima Solange; Rocha, Rafael Malagoli; Soares, Fernando Augusto; Brentani, Maria M.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Hosp AC Camargo Fund Antonio PrudenteAims:Fos-related antigen 1 (Fra-1) is a member of the activator protein 1 (AP-1) transcription factor family. Our objective was to evaluate the role of Fra-1 expression in breast carcinoma progression and prognosis.Methods and results:Fra-1 expression was investigated by immunohistochemistry in two tissue microarrays containing, respectively, 85 ductal carcinoma in situ (DCIS) and 771 invasive ductal carcinoma (IDC) samples. Staining was observed in the nucleus and cytoplasm of the carcinomas, but only nuclear staining was considered to be positive. Fibroblasts associated with IDC were also Fra-1-positive. the frequency of Fra-1 positivity in IDC (22.8%) was lower than that in DCIS (42.2%). No association was found between Fra-1 and clinico-pathological variables in DCIS. in IDC, Fra-1 expression correlated with aggressive phenotype markers, including: high grade, oestrogen receptor negativity and human epidermal growth factor receptor 2 (HER-2) positivity (P = 0.001, 0.015 and 0.004, respectively), and marginally with the presence of metastasis (P = 0.07). Fra-1 was more frequently positive in basal-like (34%) and in HER-2-positive (38.5%) subtypes than in luminal subtypes. Fra-1 presence did not correlate with survival.Conclusions:A high frequency of Fra-1 in DCIS tumours may be associated with early events in breast carcinogenesis. Although Fra-1 expression correlated with features of a more aggressive phenotype in IDC, no relationship with overall survival was found.